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anti-Rat (Rattus) Antibodies:
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Ubiquitin-dependent signaling during the DNA damage response (DDR (show DDR1 Antibodies)) to double-strand breaks is initiated by two E3 ligases, RNF8 (show RNF8 Antibodies) and RNF168 (show RNF168 Antibodies), targeting histone H2A and H2AX (show H2AFX Antibodies). Study shows that ubiquitin chains per se are insufficient for signaling, but RNF168 (show RNF168 Antibodies) target ubiquitination is required for DDR (show DDR1 Antibodies) damage.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
H2A histone family, member O
, histone 2, H2aa3
, histone H2A type 2-A
, histone 2, H2aa
, histone cluster 2, H2aa
, histone cluster 2, H2aa1