Browse our anti-TERT (TERT) Antibodies

Human Telomerase Reverse Transcriptase (TERT) interaction partners

1. Results showed both in retinoid-treated cell lines and in acute promyelocytic leukemia (APL) patient cells an inverse relationship between the expression of H19 and the expression and activity of hTERT. Exploring the mechanistic link between H19 and hTERT regulation, data showed that H19 is able to impede telomerase function by disruption of the hTERT-hTR interaction.

2. Either inhibition of telomerase by BIBR 1532 or AR blockages by enzalutamide decreased prostate-specific antigen (PSA) and the catalytic component of telomerase, hTERT, expression. These results suggest that telomerase inhibition therapy may contribute to the efficacy of enzalutamide in the androgen-sensitive prostate cancer model.

3. Xenobiotic Response Elements (XREs) from Human CYP1A1 Gene Enhance the hTERT Promoter Activity.

4. the presence of a TERT promoter mutation in meningioma can be associated with worse prognosis, and shorter overall survival (Systematic Review)

5. TERT promoter mutation proved an independent predictor of distant metastases in patients with follicular-derived thyroid cancers.

6. Our results indicate that hotspot TERT promoter mutation status may be a useful ancillary parameter for the diagnosis of melanoma

7. Lower PFKFB2 methylation levels was an independent factor of high relapse risk (Hazard Ratio = 3.2; CI95% = 1.19.5). PFKFB2 promoter methylation analysis has potential applicability to better stratify well-differentiated thyroid carcinomas (WDTC) patients according to the recurrence risk, independently of BRAF and TERT mutations.

8. hTERT expression correlates with the cytological grade of the cervical lesions and HPV infection status.

9. This study revealed a dynamic hTERT regulation by chromatin environment and promoter-bound transcription factors during embryonic stem cell differentiation.

10. Development of a multiplex assay to detect TERC and TERT mutations associated with immunosuppression therapy failure in Aplastic Anaemia patients.

11. In most cases, IDH1, TP53 and TERTp mutation status and MGMT and ATRX protein expression levels were stable during recurrence, which may indicate that these alterations occurred early in astrocytic tumour development.

12. Study in glioblastoma cells shows that genetic disruption of GABPbeta1L (beta1L), a tetramer-forming isoform of GABP that is dispensable for normal development, results in TERT silencing in a TERT promoter mutation-dependent manner. Reducing TERT expression by disrupting beta1L culminates in telomere loss and cell death exclusively in TERT promoter mutant cells.

13. neither forced vital capacity decline nor diffusing capacity of the lung for carbon monoxide decline was improved by pirfenidone in patients with lung fibrosis and a TERT/TERC mutation

14. Mean serum telomerase levels (ng/mL) were 2.76 (IQR = 0.94) in the control group, 10.79 (IQR = 2.37) in the thermal burn group, and 18.96 (IQR = 2.80) in the high voltage electrical burn group. The differences were statistically significant.

15. The evidence presented in this article of possible interactions between TERT and a discrete subset of known stem cell markers would significantly contribute to further enquiries regarding clonal dynamics in the context of human breast cancer.

16. Our data suggest that TERT C228T promoter mutations may have an important role in progression of adult granulosa cell tumors

17. Telomerase reverse transcriptase promoter mutations are early events in conjunctival neoplasia and could be used for timely diagnosis of conjunctiva tumours.

18. Study presents a novel genome-wide candidate for ductal adenocarcinoma (PDAC) - TERT-rs2736100 and a completely new signal for PDAC in NAF1-rs7675998 that approaches the genome-wide threshold. In addition, study found a strong association between the teloscore and risk of pancreatic cancer, suggesting that telomeres are a potential risk factor for pancreatic cancer.

19. TERT expression and role in the cell proliferation and apoptosis in hepatocellular cancer.

20. SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment.

Caenorhabditis elegans (C. elegans) Telomerase Reverse Transcriptase (TERT) interaction partners

1. The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.

2. Telomerase may be required to prevent or repair sporadic telomere truncations that are unrelated to the typical 'end-replication' problems.

3. trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase

Cow (Bovine) Telomerase Reverse Transcriptase (TERT) interaction partners

1. Ectopic expression of human telomerase RNA component results in increased telomerase activity and elongated telomeres in bovine blastocysts.

Zebrafish Telomerase Reverse Transcriptase (TERT) interaction partners

1. The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.

2. methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated

3. Telomerase is essential for heart muscle regeneration in zebrafish.

4. Telomerase-deficient zebrafish show p53-dependent premature aging and reduced lifespan in the first generation.

5. Thus, telomerase is limiting for zebrafish lifespan, enabling the study of telomere shortening in naturally ageing individuals.

6. a direct relationship between the expression of telomerase, telomere length and the efficiency of tissue regeneration

7. telomerase expression and telomere length are unaffected by either age or limb regeneration in Danio rerio

8. Role of telomerase in vertebrate central nervous system (CNS) other than telomere maintenance, such as regulation of cell cycle progression and maintenance of retinal cell phenotypes.

9. These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.

Arabidopsis thaliana Telomerase Reverse Transcriptase (TERT) interaction partners

1. Telomere shortening is more rapid in fas tert double mutants than in fas1, fas2 or tert single mutant plants.

2. Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.

3. study reports the physical interaction of an Arabidopsis POT1 protein, POT1A (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant

4. AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 associates with active telomerase RNP particles in an RNA-dependent manner.

5. Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.

Medaka Telomerase Reverse Transcriptase (TERT) interaction partners

1. Results indicate that the architecture for the vertebrate telomerase RNA (TR) template/pseudoknot (t/PK) is conserved from teleost fish to human.

2. Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.

3. The Japanese medaka is a new vertebrate model for studying tert biology.

Mouse (Murine) Telomerase Reverse Transcriptase (TERT) interaction partners

1. Telomerase contributes to lymphocyte proliferation but plays no major role in Treg function, provided that telomere length is not critically short. Oxidative stress may contribute to atherosclerosis via suppression of telomerase and acceleration of telomere attrition in Tregs.

2. Data show that snail family zinc finger 1 (Snail1)-deficient mesenchymal stem cells (MSC) present higher levels of both telomerase activity and the long non-coding RNA called telomeric repeat-containing RNA (TERRA), an RNA that controls telomere integrity.

3. This study revealed a dynamic hTERT regulation by chromatin environment and promoter-bound transcription factors during embryonic stem cell differentiation.

4. Par-4 activation and binding to TERT are key steps required for inducing the apoptosis of islet beta cells under high-glucose/fatty acid conditions in type 2 diabetes.

5. Tert-deficient but not Terc-deficient mice develop hepatocyte injury and frank steatosis when challenged with liquid high-fat diet.

6. identification of a subset of hepatocytes that expresses high levels of telomerase and show that this hepatocyte subset repopulates the liver during homeostasis and injury

7. These preclinical data in mouse models and human cells provide a strong rationale for the development of pharmacological approaches to target BMI1-mediated mitochondrial regulation and protection from DNA damage to sustain the regenerative potential of the skeletal muscle in conditions of chronic muscle wasting.

8. Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.

9. Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma.

10. TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.

11. these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.

12. Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc, Cyc-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment

13. Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress

14. Wnt10a/beta-catenin signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.

15. This study reports the characterisation of two novel mouse TERT splice variants, Ins-i1[1-102] (Insi1 for short) and Del-e12[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.

16. TERT may promote gastric cancer metastasis through the TERT-miR-29a-ITGB1 regulatory pathway.

17. TERT switches macrophages towards M1 phenotype by regulating NF-kappaB signaling, but has limited effect on M2 macrophages polarization in vitro.

18. The results suggest that the mouse endometrial epithelium and vasculature are foci of stem/progenitor activity expressing mTert.

19. miR-195 overexpressed in old mesenchymal stem cells (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging.

20. These findings indicate that telomerase gene therapy represents a novel therapeutic strategy to treat aplastic anemia provoked or associated with short telomeres.

Xenopus laevis Telomerase Reverse Transcriptase (TERT) interaction partners

1. TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt/beta-catenin signalling pathway