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anti-Human TERT Antibodies:
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Human Monoclonal TERT Primary Antibody for ICC, FACS - ABIN151783
Masutomi, Yu, Khurts, Ben-Porath, Currier, Metz, Brooks, Kaneko, Murakami, DeCaprio, Weinberg, Stewart, Hahn: Telomerase maintains telomere structure in normal human cells. in Cell 2003
Show all 15 Pubmed References
Human Monoclonal TERT Primary Antibody for FACS, ICC - ABIN151763
Zhang, Eguchi, Kruse, Gomez, Fakhrai, Schroter, Ma, Hoa, Minev, Delgado, Wepsic, Okada, Jadus: Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Show all 10 Pubmed References
Dog (Canine) Polyclonal TERT Primary Antibody for ICC, IF - ABIN265626
Walshe, Harkin: Serial explant culture provides novel insights into the potential location and phenotype of corneal endothelial progenitor cells. in Experimental eye research 2014
Show all 3 Pubmed References
Mouse (Murine) Polyclonal TERT Primary Antibody for WB - ABIN3043095
Qiu, Li, Sui, Sun, Huang, Si, Ge: Immunization with truncated sequence of Telomerase Reverse Transcriptase induces a specific antitumor response in vivo. in Acta oncologica (Stockholm, Sweden) 2007
Show all 2 Pubmed References
Human Polyclonal TERT Primary Antibody for IF (cc), IF (p) - ABIN686167
Gao, Zhao, Song, Yang: Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs. in Molecular biology reports 2012
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Human Polyclonal TERT Primary Antibody for DB, IF - ABIN390002
Radan, Hughes, Teichroeb, Vieira Zamora, Jewer, Postovit, Betts: Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. in Stem cells and development 2014
Show all 2 Pubmed References
Human Polyclonal TERT Primary Antibody for FACS, IF - ABIN388165
Sekaric, Cherry, Androphy: Binding of human papillomavirus type 16 E6 to E6AP is not required for activation of hTERT. in Journal of virology 2007
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Pulmonary fibrosis patients with mutations in telomerase reverse transcriptase, telomerase RNA component, regulator of telomere elongation helicase 1 (show RTEL1 Antibodies) and poly(A)-specific ribonuclease (show PARN Antibodies) were identified and clinical data were analysed. Genetic mutations in telomere related genes lead to a variety of interstitial lung disease diagnoses that are universally progressive.
No significant difference in the frequency of the TERT promoter mutation was observed between the persistence/recurrence group and the non-recurrence group in papillary thyroid cancer.
mutations in TERT promoter and in CTNNB1 (show CTNNB1 Antibodies) gene represent specific cancer signatures in the pathogenesis of viral related hepatocellular carcinoma.
Prevalence of TERT/TERC disease-associated variant (DAV) did not significantly differ between patients with familial pulmonary fibrosis or with only telomere syndrome features. Young age, red blood cell macrocytosis, and low platelet count were associated with the presence of DAV; the probability of DAV was increased for patients 40-60 years. TERT/TERC DAV were associated with reduced transplant-free survival.
This study shown that M1 polarization strongly represses genes associated with the telomere complex. Importantly, both ischemia and Alzheimer's-like pathology recapitulated this cell type-specific pattern of reduced Tert mRNA expression in vivo.
The data demonstrate that cells arrested in oncogene (show RAB1A Antibodies)-induced cellular senescence retain the potential to escape senescence by mechanisms that involve derepression of TERT expression.
genetic association studies in population in China: Data suggest that an SNP in TERT (rs2735940, C>T), an SNP associated with genetic predisposition for cancer, exhibits allele frequencies of 63% for allele C and 37% for allele T in the Chinese Han population studied.
High TERT expresiion is associated with medullary thyroid carcinoma.
Results show that promoter mutations render telomerase reverse transcriptase (TERT) expression dependent on MAPK (show MAPK1 Antibodies) signal pathway activation due to oncogenic BRAF (show BRAF Antibodies) or NRAS (show NRAS Antibodies) mutations.
Data suggest that the Kruppel-like factor 4 (KLF4 (show KLF4 Antibodies)) /telomerase reverse transcriptase (hTERT)/MAPK (show MAPK1 Antibodies) pathway is a potential new therapeutic target for lung cancer.
The results establish that null mutation in trt-1 improves survival and attenuates damage to the DAergic system.
trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase
The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
methylation status of the genes of telomerase reverse transcriptase (tert) and telomerase RNA (terc) was determined in brain tissues; study found that, regardless of the age of fish, the regulatory region of the tert gene was completely methylated, whereas the coding region remained unmethylated
Telomerase-deficient zebrafish show p53 (show TP53 Antibodies)-dependent premature aging and reduced lifespan in the first generation.
These results suggest that TERT non-canonically functions in hematopoietic cell differentiation and survival in vertebrates, independently of its role in telomere homeostasis.
Telomere shortening is more rapid in fas (show FASN Antibodies) tert double mutants than in fas1 (show FAS Antibodies), fas2 or tert single mutant plants.
Silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
study reports the physical interaction of an Arabidopsis POT1 (show POT1 Antibodies) protein, POT1A (show POT1 Antibodies) (At5g05210), with an N-terminal peptide of the catalytic subunit of the telomerase TERT encoded by a 5' mRNA splicing variant
AtTERT, the telomerase catalytic subunit, accumulates in the plant nucleolus, and AtNAP57 (show DKC1 Antibodies) associates with active telomerase RNP (show RNPC3 Antibodies) particles in an RNA-dependent manner.
Attert (-/-) mutant plants were propagated from seeds coming either from the lower-most or the upper-most siliques (L- and U-plants) and the length of their telomeres were followed over several generations.
Tert was cloned from testis. It is expresed in embryo and adult, mostly in gonad and brain. 2 splice variants and an antisense transcript were identified.
The Japanese medaka is a new vertebrate model for studying tert biology.
Reactivation of Tert in the hippocampus was sufficient to normalize the depressive but not the aggressive behaviors of Tert(-/-) mice. Conversely, re-expression of Tert in the medial prefrontal cortex (mPFC) reversed the aggressive but not the depressive behavior of Tert(-/-) mice.
Nrf2 (show NFE2L2 Antibodies)-driven TERT regulates pentose phosphate pathway in glioblastoma.
TERT has a role in neointima formation through epigenetic regulation of proliferative E2F1 (show E2F1 Antibodies) target gene expression in smooth muscle cells.
these findings support a model in which gain of TERT function modulates mTORC1 activity and induces autophagy.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc (show MYC Antibodies), Cyc (show CYCS Antibodies)-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment
Results suggest that in mature Purkinje neurons, TERT is present both in the nucleus and in mitochondria, where it may participate in adaptive responses of the neurons to excitotoxic and radiation stress
Wnt10a (show WNT10A Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT.
This study reports the characterisation of two novel mouse TERT splice variants, Ins (show INS Antibodies)-i1[1-102] (Insi1 for short) and Del-e12 (show ELSPBP1 Antibodies)[1-40] (Dele12 for short) that have not been previously described. Insi1 represents an in-frame insertion of nucleotides 1-102 from intron 1, encoding a 34 amino acid insertion at amino acid 73.
TERT may promote gastric cancer metastasis through the TERT-miR (show MLXIP Antibodies)-29a-ITGB1 (show ITGB1 Antibodies) regulatory pathway.
TERT switches macrophages towards M1 phenotype by regulating NF-kappaB (show NFKB1 Antibodies) signaling, but has limited effect on M2 macrophages polarization in vitro.
TERT serves an essential role in formation of the anterior-posterior axis in Xenopus laevis embryos; role for telomerase as a transcriptional modulator of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signalling pathway
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified\; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
telomerase catalytic subunit
, telomerase-associated protein 2
, Telomerase Reverse Transcriptase family member (trt-1)
, telomerase reverse transcriptase
, hypothetical protein
, telomerase reverse transcriptase beta
, Telomerase catalytic subunit