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anti-Human CREB3 Antibodies:
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Human Polyclonal CREB3 Primary Antibody for WB - ABIN1881228
Kim, Choi, Choi, Kang, Kim, Lee, Lee, Lee, Kim, Jun, Jeong, Yoon: HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells. in Cellular and molecular life sciences : CMLS 2010
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Cow (Bovine) Polyclonal CREB3 Primary Antibody for WB - ABIN2780771
Mamdani, Alda, Grof, Young, Rouleau, Turecki: Lithium response and genetic variation in the CREB family of genes. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008
CREB3 was identified as a transcriptional regulator of upregulated ER-Golgi trafficking genes ARF4, COPB1, and USO1, and silencing of these genes attenuated the metastatic phenotype in vitro and lung colonization in vivo. Modulation of ER-Golgi trafficking plays an important role in metastatic progression.
Luman, a ubiquitous, non-canonical unfolded protein response (UPR), is identified as a novel regulator of endoplasmic reticulum stress-induced PRNP expression.
In summary, the authors show here that hepatitis C virus infection is associated with an upregulation of ARF4, which promotes hepatitis C virus replication. Upon hepatitis C virus infection, CREB3 was redistributed to nucleus and activated ARF4 transcription.
sLZIP is a novel co-repressor of ERalpha, and plays a negative role in ERalpha-mediated cell proliferation in breast cancer
These findings indicate that LZIP is a novel modulator of APOA4 expression and hepatic lipid metabolism.
The authors found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis.
The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the CREB3 pathway.
These results indicate that sLZIP plays a role in expression of c-Jun, and migration and invasion of cervical cancer cells via regulation of MMP-9 transcription.
INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE.
Findings indicate that sLZIP negatively regulates AR transactivation in androgen-dependent PCa cells and functions as a positive regulator in tumor progression of androgen-independent PCa. sLZIP contributes to the malignant phenotype of PCa.
human sLZIP plays a critical role in development of atherosclerosis and can be used as a therapeutic target molecule for treatment of atherosclerosis
A CREB3-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity.
propose that JAB1 is a novel binding partner of Luman, which negatively regulates the activity of Luman by promoting its degradation
GSK3beta was downregulate in all samples and CREB3 did not show a significant decrease or increase in its mRNA expression, but the results were significant in mucoepidermoid carcinoma and salivary duct carcinoma.
sLZIP plays a critical role in MMP-9 expression and is probably involved in invasion and metastasis of cervical cancer
sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration.
These findings suggest that HDAC3 selectively represses CREB3-mediated transcriptional activation and chemotactic signalling in human metastatic breast cancer cells.
DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation.
sLZIP functions as a negative regulator in glucocorticoid-induced transcriptional activation of GR by recruitment and activation of HDACs
Data show that Luman is processed by regulated intramembrane proteolysis. The site 1 protease (S1P), a Golgi-resident enzyme, may be involved in the processing of Luman.
This finding is especially true for the unique action of the copper ion on CREB3 stabilization and processing in parallel to aberration of ubiquitin-proteasome system, which might provide new insights into understanding the mechanisms of intractable disorders.
LUMAN is a key regulator of glucocorticoid receptor-mediated signaling.
Luman regulates mouse granulosa cell modulation of steroid synthesis, cell cycle activity and other regulators of folliculogenesis
LRF seems to be involved in the regulation of decidualization during pregnancy.
These results suggest that Luman regulates the multinucleation of osteoclasts by promoting cell fusion of mononuclear osteoclasts through DC-STAMP induction and intracellular distribution during osteoclastogenesis.
sLZIP is a novel PPARgamma2 modulator for control of the balance between adipogenesis and osteogenesis during Mesenchymal stem cell differentiation
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
Luman might have important roles in embryo implantation and decidualization.
Luman recruiting factor might be involved in inducing apoptosis of granulosa cells through the endoplasmic reticulum stress pathway in mice
Data show that ApoA4 is a true target gene of LUMAN in bone marrow-derived DCs (BMDCs).
Luman/CREB3 recruitment factor inhibits Luman activation of the unfolded protein response
Tissue transcription analysis revealed that both porcine CREB2 and CREB3 mRNA were ubiquitously detected in all examined tissues.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
, basic leucine zipper protein
, cAMP-responsive element-binding protein 3
, cyclic AMP response element (CRE)-binding protein/activating transcription factor 1
, cyclic AMP-responsive element-binding protein 3
, leucin zipper proitein
, leucine zipper protein
, transcription factor LZIP-alpha
, transcription factor LZIP
, cAMP responsive element binding protein 3 (luman)
, cAMP responsive element-binding protein 3