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Human Monoclonal IRF3 Primary Antibody for Inhibition, IF - ABIN967285
Au, Moore, Lowther, Juang, Pitha: Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. in Proceedings of the National Academy of Sciences of the United States of America 1996
Show all 8 Pubmed References
Mouse (Murine) Polyclonal IRF3 Primary Antibody for WB - ABIN1881465
Marichal, Bedoret, Mesnil, Pichavant, Goriely, Trottein, Cataldo, Goldman, Lekeux, Bureau, Desmet: Interferon response factor 3 is essential for house dust mite-induced airway allergy. in The Journal of allergy and clinical immunology 2010
Show all 5 Pubmed References
Human Polyclonal IRF3 Primary Antibody for ICC, ELISA - ABIN1002559
Malmgaard: Induction and regulation of IFNs during viral infections. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004
Show all 4 Pubmed References
Human Polyclonal IRF3 Primary Antibody for IHC, ELISA - ABIN1002558
Fitzgerald, McWhirter, Faia, Rowe, Latz, Golenbock, Coyle, Liao, Maniatis: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. in Nature immunology 2003
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Human Polyclonal IRF3 Primary Antibody for IF (cc), IF (p) - ABIN742688
Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection. in Journal of virology 2013
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Human Polyclonal IRF3 Primary Antibody for IF (cc), IF (p) - ABIN742695
Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. in Journal of immunology (Baltimore, Md. : 1950) 2014
Human Polyclonal IRF3 Primary Antibody for IF (p), IHC (p) - ABIN682588
Fan, Li, Zhu, Sui, Chen, Deng, Sui, Wang: NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows. in Biotechnology letters 2016
Human Monoclonal IRF3 Primary Antibody for IP, ELISA - ABIN2475141
Takahasi, Suzuki, Horiuchi, Mori, Suhara, Okabe, Fukuhara, Terasawa, Akira, Fujita, Inagaki: X-ray crystal structure of IRF-3 and its functional implications. in Nature structural biology 2003
Human Polyclonal IRF3 Primary Antibody for WB - ABIN2668684
Goriely, Molle, Nguyen, Albarani, Haddou, Lin, De Wit, Flamand, Willems, Goldman: Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation. in Blood 2006
Mouse (Murine) Polyclonal IRF3 Primary Antibody for IHC, WB - ABIN3023115
Zhong, Wang, Fang, Zhang, Luo, Shang, Ouyang, Ouyang, Chen, Xiao: Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. in PLoS ONE 2013
Following spring viremia of carp (show ANKRD1 Antibodies) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Antibodies) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Antibodies)-dependent regulatory mechanism fine-tuning IFN gene activation.
Interferon regulatory factor (IRF (show TRIM63 Antibodies))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.
Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
MyD88 (show MYD88 Antibodies) interacts with interferon regulatory factor (IRF) 3 and IRF7 (show IRF7 Antibodies) in Atlantic salmon (Salmo salar)
beta-catenin (show CTNNB1 Antibodies) interacted with IRF3 and blocked its nuclear translocation.
Upregulation of endogenous SAMHD1 (show SAMHD1 Antibodies) expression is attributed to the phosphorylation and nuclear translocation of IRF3.
In this work, the authors found that differences in type 1 interferon production by T1 and T3 reoviruses correlate with differential IRF3 activation.
Proteins 8b and 8ab of severe acute respiratory syndrome coronavirus physically interact with IRF3 and in induced degradation of IRF3 in a ubiquitin-proteasome-dependent manner.
Our results highlight the importance of IRF3 and type-I IFNs signaling for the pro-apoptotic effects induced by RA and synthetic dsRNA in breast cancer cells.
In the current study, we studied the role of MITA (Mediator of IRF3 Activation (show TMEM173 Antibodies)), a regulator of innate immunity, in the regulation of autophagy and its implication in cell death of breast cancer cells. Here, we report that MITA (show TMEM173 Antibodies) inhibits the fusion of autophagosome with lysosome as evident from different autophagy flux assays
New research suggests that altering a subset of extracellular matrix factors, including interferon regulatory factor (IRF)3 and casein kinase (CK)2 (show CSNK2A1 Antibodies), may decrease the migratory potential of these aggressive tumors.
IRF-3 gene polymorphisms were associated with the susceptibility and prognosis of CLL, it can be used as an auxiliary index for clinical detection of CLL.
Clarithromycin acts a crucial modulator of the innate immune response, particularly IFN production, by modulating IRF-3 dimerization and subsequent translocation to the nucleus of airway epithelial cells.
c-Cbl (show CBL Antibodies) negatively regulates IFN-beta (show IFNB1 Antibodies) signaling and cellular antiviral response by promoting IRF3 ubiquitination and degradation.
The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha/beta production.
The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (show IFNB1 Antibodies) promoter activity in MARC (show CCL7 Antibodies)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.
proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).
this study shows that activation of IRF3 contributes to IFN-gamma (show IFNG Antibodies) and ISG54 (show IFIT2 Antibodies) expression during the immune responses to B16F10 tumor growth
IRF3 exacerbates P. aeruginosa-induced mortality in mice by inhibiting neutrophil adhesion and recruitment to the lungs
IRF3 expression and activation depend on the signal transduction of the the urotensin II (show UTS2 Antibodies)/urotensin receptor (show UTS2R Antibodies) (UII (show UTS2 Antibodies)/UT) system, and play important roles in UII (show UTS2 Antibodies)/UT
Interruption of IRF3-dependent signaling resulted in decreased cardiac expression of inflammatory cytokines and chemokines and decreased inflammatory cell infiltration of the heart, as well as in attenuated ventricular dilation and improved cardiac function.
This study reveals a critical role of NSD3 (show WHSC1L1 Antibodies)-mediated IRF3 methylation in enhancing antiviral innate immunity.
these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 (show EGR2 Antibodies) and YY1 (show YY1 Antibodies) in NIH3T3 cells
Data show that stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3-independent immune cell dysregulation and lung disease in mice.
study provided evidence that the ability of ICP34.5 to control IRF3 activation is through its ability to reverse translational shutoff and sustain the expression of other IFN inhibitors encoded by the virus
This study did not find non-conservative mutations among SJL, B10.S, B6 and B10 mice in the IRF3 amino acid sequence, and show SJL bone marrow-derived macrophages infected with Theiler's murine encephalomyelitis virus exhibit increased virus RNA replication and infectious virus yields as well as greater IL-6 production than C57Bl strain (including B10.S) cultures.
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (show IFNB1 Antibodies) promoter activity and induces IRF3 degradation.
cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon synthesis.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
interferon regulatory factor 3
, interferon regulatory factor 3-like