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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
Show all 2 Pubmed References
Cerebrospinal fluid soluble TLR2 and TLR4 may play a role in HIV/SIV-related neuroinflammation and subsequent neuropathology.
data confirm that engineered human cells expressing TLR4, MD2 (show LY96 Proteins) and CD14 (show NDUFA2 Proteins) can respond to CMP (show MATN1 Proteins) with NF-kappaB (show NFKB1 Proteins) activation and the response can be influenced by variations in CMP (show MATN1 Proteins)-mannosylation
RBP4 (show POLR2D Proteins)-induced inflammation is largely mediated by TLR4.
novel observation that sCD14 compared with lipopolysaccharide binding protein (show LBP Proteins), offers a preferred target to ameliorate TLR especially TLR4-induced inflammation and insulin (show INS Proteins) resistance in human obesity and metabolic syndrome
Data suggest that dendritic cells are sensitive to environmentally relevant level of aflatoxin B1 (AFB1); TLR2 and TLR4 are involved in sensing AFB1; expression levels of both TLR2 and TLR4 mRNA and proteins were significantly up-regulated in AFB1-treated dendritic cells.
For asthma, there was suggestive evidence of a gene-by-environment interaction for the CD14 (show NDUFA2 Proteins) variant rs2569190 (Interaction P = 0.16) but not for the TLR4 variants rs4986790 and rs4986791.
Toll-like receptor 4 may have a role in non-small cell lung cancer
Activation of TLR3 (show TLR3 Proteins) and TLR4 stimulated the expression of HIF-1 (show HIF1A Proteins) through NF-kappaB (show NFKB1 Proteins) in oral squamous cell carcinoma
essential role of TLR4/ROS (show ROS1 Proteins)/miR (show MLXIP Proteins)-21 pathway in LPS (show IRF6 Proteins)-induced outgrowth of primary human lung cancer
An association with IL-1beta (show IL1B Proteins)-511 locus and IL-1beta (show IL1B Proteins)-511-TLR4-896 diplotype (CC-AA) and Type 2 Diabetes Mellitus is discussed.
tissue damage induced NADPH oxidase (show NOX1 Proteins) activation and increased the release of reactive oxygen species via cold-inducible RNA-binding protein (CIRP (show CIRBP Proteins))-TLR4-MyD88 (show MYD88 Proteins) signaling.
the anti-inflammatory effect of Saikosaponin a is associated with activating LXRalpha (show NR1H3 Proteins) dependent cholesterol efflux pathway which result in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 to lipid rafts, thereby attenuating LPS mediated inflammatory response
analysis of TLR2 rs5743708, TLR2 rs4696480, TLR4 rs4986790, TLR9 (show TLR9 Proteins) rs5743836 and TLR9 (show TLR9 Proteins) rs352140 SNPs in children with pneumococcal and meningococcal meningitis and their family members; study did not show an association between the analyzed SNPs in TLR2, TLR4, and TLR9 (show TLR9 Proteins) and susceptibility to develop bacterial meningitis
TLR4 deletion does not protect from cast immobilization-induced muscle atrophy.
PCSK9 (show PCSK9 Proteins) may act as an inflammatory mediator in the pathogenesis of atherosclerosis via TLR4/NF-kappaB (show NFKB1 Proteins) signaling pathway.
ESAT6 may induce renal injury by promoting miR (show MLXIP Proteins)-155 expression through the TLR-4/MyD88 (show MYD88 Proteins) signaling pathway in MTB (show NCAPG2 Proteins)-infected mice.
Ultraviolet radiation engages TLR4/MyD88 (show MYD88 Proteins) as a death signaling complex in macrophages.
These results suggest that TLR2 and TLR4 play cooperative roles in lung innate immune responses and bacterial dissemination, resulting in systemic inflammation during Klebsiella pneumoniae infection.
Findings identify a critical role for IL1Ra (show IL1RN Proteins) in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice.
TLR4-NF-kappaB (show NFKB1 Proteins) signal pathway is inhibited by paeonol in endotoxin-induced acute kidney injury
STA3 (show ARHGEF3 Proteins) facilitates TLR4-dependent IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) production via IL-6 (show IL6 Proteins) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Proteins) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (show CCL2 Proteins)) genes.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein