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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
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Report shows that rheumatoid arthritis (RA) patients express functional TLR4 on peripheral CD8+ T cells that directly promote T-cell function and differentiation to Tc1. The study also suggests that TLR4 signals directly drive Tc1 development and T cell activation independent of TCR engagement.
Resistin (show RETN Proteins) promoted lung adenocarcinoma metastasis through the TLR4/Src (show SRC Proteins)/EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.
imcreased TLR4 expression in gastric cardia lesions may be associated with gastric cardia cancer tumorigenesis
The immunoenhancement effect of PSP (show MSMB Proteins) against lung cancer is mediated by TLR4-MAPK (show MAPK1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathways
LPS (show IRF6 Proteins) stimulation induced TLR4 expression and increased pigmentation. TLR4 expression was not detected after single-dose UVA or UVB treatment, but pigmentation increased. Repeated UV treatment induced TLR4 expression and increased pigmentation. LPS (show IRF6 Proteins) stimulation and repeated UV treatment increased IL-6 (show IL6 Proteins) secretion, and repeated UVB treatment increased IL-10 (show IL10 Proteins) secretion.
data suggest that high-phosphate conditions directly induce vascular calcification via the activation of TLR4/NF-kappaB (show NFKB1 Proteins) signaling in VSMCs
LncRNA MEG3 (show FAM129B Proteins) ameliorates respiratory syncytial virus infection by suppressing TLR4 signaling.
Study shows that the toll-like receptor 4 gene rs1927914 polymorphism was associated with susceptibility to ischemic stroke in males. Moreover, the rs10759932 polymorphism may affect inflammatory response in ischemic stroke patients.
There was no difference found in MMP-2 (show MMP2 Proteins), MMP-9 (show MMP9 Proteins) or TLR-4 levels between non-thrombocytopenic and thrombocytopenic septic donors. PLA formation was increased in thrombocytopenic patients.
there was a negative correlation between YKL-40 (show CHI3L1 Proteins) and TLR4 expression in chronic sinusitis patients with nasal polyps. YKL-40 (show CHI3L1 Proteins) and TLR4 interacted with each other to activate NF-kappaB (show NFKB1 Proteins) and promote disease progression.
Study showed the significance of TLR4 in upregulation of MAPK/ErK (show MAPK1 Proteins) in NMDAR (show GRIN1 Proteins) hypofunction schizophrenic-mouse model. This is characterized by a decrease in hippocampal IGF-1R (show IGF1R Proteins)/CaMKIIalpha, and social interaction behavioral deficits. Ultimately, hippocampal TLR4 knockdown rescued IGF-1R (show IGF1R Proteins)/CaMKIIalpha decline and prevented behavioral deficits by reducing MAPK/ErK (show MAPK1 Proteins) expression.
Study highlights the importance of Ca(2 (show CA2 Proteins)+) signaling in macrophage activation and identifies the ion channel TRPM7 (show TRPM7 Proteins) as a central component of TLR4 signaling.
The immunoenhancement effect of PSP against lung cancer is mediated by TLR4-MAPK (show MAPK1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathways
knockout of TLR4 gene improved survival and cardiac function in severe sepsis induced by CLP by decreasing the myocardial levels of inflammatory cytokines, weakening neutrophil infiltration in myocardium, and attenuating the heart apoptosis.
beta-arrestin 2 (show ARRB2 Proteins) can protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-kappaB (show NFKB1 Proteins) signaling pathway-mediated inflammation.
TLR4 mutation can decrease the expression of inflammatory factors and enhance the speed of recovery after sciatic nerve injury.
Toll-like receptor (TLR) 4, the expression of which was upregulated in B cells after ultraviolet B exposure, played an essential role in the induction of regulatory B cells.
type I and II IFN as in vivo modifiers of LIC fate that may significantly affect the impact of putative leukemia-driving activities such as the ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins)-mediated growth advantage in the presence of TGF-beta (show TGFB1 Proteins) and TLR4-upregulated mutagenic activity
Pudilan xiaoyan oral liquid prevents LPS-induced respiratory in fl ammation via effects on TLR4/NF-kappaB (show NFKB1 Proteins) signaling.
NOD2 Modulates Serotonin Transporter (show SLC6A4 Proteins) and Interacts with TLR2 and TLR4 in Intestinal Epithelial Cells
Based on the impact of both candidate genes,TLR4 and CACNA2D1 (show CACNA2D1 Proteins), on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
STA3 (show ARHGEF3 Proteins) facilitates TLR4-dependent IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) production via IL-6 (show IL6 Proteins) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Proteins) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).
The TWEAK (show TNFSF12 Proteins)-independent Fn14 (show TNFRSF12A Proteins) activation augments TLR4-mediated inflammatory responses in the intestine of piglets.
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (show HPSE Proteins) axis induced by LPS (show IRF6 Proteins) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein