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Human TLR4 Protein expressed in Wheat germ - ABIN1322876
Hendriks, Hua, Chabot: Analysis of mechanistic pathway models in drug discovery: p38 pathway. in Biotechnology progress 2008
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The findings show that the expression of TLR2, TLR4 and TLR9 (show TLR9 Proteins), and hypoxia markers HIF-1alpha (show HIF1A Proteins) and CAIX (show CA9 Proteins) is abnormal in pancreatic intraepithelial neoplasia suggesting that both the innate immunity activation and hypoxia response are involved in early pancreatic carcinogenesis.
The role of IDO1 (show IDO1 Proteins)-IDO2 (show IDO2 Proteins)-AHR (show AHR Proteins) pathway in the TLR4-induced tolerogenic phenotype in human dendritic cells has been reported.
TLR4 Asp299Gly polymorphism potentially leading to the development of recurrent hydatidosis, by skewing the immune system towards a Th2 response
Study demonstrated that HMGB1 (show HMGB1 Proteins) and TLR4 could contribute to the inflammatory lichen planus process in skin.
Physical interaction between p38 (show CRK Proteins) and eNOS (show NOS3 Proteins) was demonstrated by immunoprecipitation, suggesting a novel, NO-independent mechanism for eNOS (show NOS3 Proteins) regulation of TLR4. In correlation, biopsy samples in patients with systemic lupus erythematous showed reduced eNOS (show NOS3 Proteins) expression with associated elevations in TLR4 and p38 (show CRK Proteins), suggesting an in vivo link.
The overexpression of miR (show MLXIP Proteins)-140 inhibited the upregulation of the expression of TLR4.
TLR4 small interfering RNA blocked hUGT1A1/hNRs downregulation.
The expression of TLR4 in perihematoma tissue began to increase within 6 hours after intracerebral hemorrhage and decreased after 72 hours.
miR (show MLXIP Proteins)-20a could negatively regulate TLR4 and NLRP3 (show NLRP3 Proteins) signaling to protect human aortic endothelial cells from inflammatory injuries.
Study provides clear evidence that resistin (show RETN Proteins) is a clinically relevant endogenous ligand for TLR4, which promotes tumor progression via TLR4/NF-kappaB (show NFKB1 Proteins)/STAT3 (show STAT3 Proteins) signaling.
miR-711, which is upregulated by Adipoq, represses TLR4 signaling, acting therefore as a major mediator of the anti-inflammatory action of Adipoq.
TLR4 expression in placenta is up-regulated during maternal murine cytomegalovirus infection.
Loss of TLR4 in the mouse retinal Muller cells impaired insulin (show INS Proteins) signal transduction.
TREM-1 (show TREM1 Proteins) may play an important role together with TLR4 in the nasopharyngeal clearance of Haemophilus influenzae by neutrophils.
TLR4-mediated p62 autophagic impairment plays an important role in the occurrence and development of neuropathic pain.
atorvastatin treatment may protect BV2 microglia and hippocampal neurons from oxygenglucose deprivationinduced neuronal inflammatory injury by suppressing the TLR4/TRAF6/NFkappaB pathway. This may provide a potential strategy for the treatment of neuronal injury.
these results suggest that TanIIA treatment is beneficial for improvement of Hypoxic ischemic encephalopathy through TLR4mediated NFkappaB signaling.
Both pharmacologic inhibition and genetic knockout of TLR4 completely abolished mesenteric lymph (ML) exosome-induced cytokine production in macrophages. Our findings define the critical role of exosomes secreted into ML as a critical mediator of trauma/hemorrhagic shock-induced acute lung injury through macrophage TLR4 activation.
TLR4 plays a regulatory role in the type 1 immune responses during C. sinensis infection, controlling release of Th1 (show HAND1 Proteins)/Th2 cytokines by infected splenocytes and dendritic cells.
This study demonstrates that the synergistic effect between TLR4 and TLR3 (show TLR3 Proteins) in macrophages is an important determinant in acute lung injury and, more importantly, that TLR3 (show TLR3 Proteins) up-regulation is dependent on TLR4-MyD88 (show MYD88 Proteins)-NF-kappaB (show NFKB1 Proteins) signaling.
Based on the impact of both candidate genes,TLR4 and CACNA2D1 (show CACNA2D1 Proteins), on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
STA3 (show ARHGEF3 Proteins) facilitates TLR4-dependent IL-6 (show IL6 Proteins) and IL-8 (show IL8 Proteins) production via IL-6 (show IL6 Proteins) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (show IL8 Proteins) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 (show CD14 Proteins) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (show NFKB1 Proteins) (p65 (show SYT1 Proteins)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (show NFKB1 Proteins) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (show ICAM1 Proteins).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (show ACSM3 Proteins) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (show ACSM3 Proteins).
Actinobacillus pleuropneumoniae induces alveolar Macrophages to produce proinflammatory cytokines via upregulation of TLR4 and NF-kappaB (show NFKB1 Proteins).
The TWEAK (show TNFSF12 Proteins)-independent Fn14 (show TNFRSF12A Proteins) activation augments TLR4-mediated inflammatory responses in the intestine of piglets.
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (show MAMLD1 Proteins) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (show IRF6 Proteins) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105 (show CD180 Proteins)/MD1 (show LY86 Proteins) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (show CLPTM1 Proteins), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (show LY96 Proteins) and CD14 (show CD14 Proteins) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (show LY96 Proteins) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein