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Human Monoclonal TLR8 Primary Antibody for CyTOF, FACS - ABIN4360386
Dasari, Zola, Nicholson: Expression of Toll-like receptors by neonatal leukocytes. in Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2011
Show all 41 Pubmed References
Human Monoclonal TLR8 Primary Antibody for FACS - ABIN4360384
Wang, Eng, Lin, Liu, Chang, Lin: Functional polymorphisms of TLR8 are associated with hepatitis C virus infection. in Immunology 2014
Show all 29 Pubmed References
Human Monoclonal TLR8 Primary Antibody for FACS - ABIN4360387
Pang, Bala, Kodys, Catalano, Szabo: Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. in BMC immunology 2011
Show all 26 Pubmed References
Human Monoclonal TLR8 Primary Antibody for ELISA - ABIN4248154
Kaji, Tanaka, Sugita, Kato, Ibata, Shono, Ohta, Kondo, Asaka, Imamura: Ciprofloxacin inhibits lipopolysaccharide-induced toll-like receptor-4 and 8 expression on human monocytes derived from adult and cord blood. in Annals of hematology 2008
Show all 21 Pubmed References
Human Monoclonal TLR8 Primary Antibody for IHC (fro), FACS - ABIN786835
Itoh, Tatematsu, Watanabe, Iwano, Funami, Seya, Matsumoto: UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling. in PLoS ONE 2011
Show all 2 Pubmed References
Human Monoclonal TLR8 Primary Antibody for IHC (fro), FACS - ABIN786834
Todt, Freeman, Brown, Sonstein, Ames, McCubbrey, Martinez, Chensue, Beck, Curtis: Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. in Respiratory research 2013
Show all 2 Pubmed References
Human Monoclonal TLR8 Primary Antibody for FACS - ABIN786839
Rochereau, Verrier, Pin, Genin, Paul: Phenotypic localization of distinct DC subsets in mouse Peyer Patch. in Vaccine 2011
Thus, TLR7 (show TLR7 Antibodies) and TLR8 might modulate different immune responses in monocytes and macrophages.
MBZ-induced IL-1beta (show IL1B Antibodies) release was found to be dependent on NLRP3 (show NLRP3 Antibodies) inflammasome activation and to involve TLR8 stimulation.
Positive rates of iNOS (show NOS2 Antibodies) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3 (show TLR3 Antibodies), TLR4 (show TLR4 Antibodies), TLR7 (show TLR7 Antibodies), TLR8, NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies), and iNOS (show NOS2 Antibodies) in cervical epithelial cells were higher in CC group than in other groups.
the current study shows that motolimod ( selective small-molecule agonist of TLR8, stimulates natural killer (NK) cells, dendritic cells, and monocytes))can be safely administered in combination with cetuximab with an acceptable toxicity profile
TLR7 (show TLR7 Antibodies) and TLR8 genetic polymorphisms are associated with susceptibility to mycobacterium tuberculosis infection, and the link is shaped by less effective MTB (show NCAPG2 Antibodies) phagocytosis and impaired TLR signaling.
Epstein-Barr virus (EBV) replication activating the toll like receptor 8 (TLR8) molecular pathway in primary monocytes.
Inhibition of Snapin (show SNAPIN Antibodies) enhanced localization of HIV-1 with TLR8(+) early endosomes, triggered a pro-inflammatory response, and inhibited trans-infection of CD4 (show CD4 Antibodies)(+) T cells.
Study evaluated innate immune profiles following TLR stimulation in HIV-1-infected mothers and newborns, found significantly compromised cytokine responses upon extracellular and intracellular TLR activation. Myeloid dendritic cell (DC) responsiveness appeared to be less impaired than plasmacytoid DCs, and might be enhanced through TLR7 (show TLR7 Antibodies)/TLR8 activation.
This is the first study illustrating certain genotypes of TLR-7 (show TLR7 Antibodies) and TLR-8 single nucleotide polymorphisms viz. CT(p = 0.002)]; rs3853839[GC(p < 0.001), CC(p = 0.039)] and rs3764879[GC(p < 0.001)] were considerably associated with Chikungunya virus susceptibility.
Data indicate a mechanism in which Toll (show TLR4 Antibodies)-like receptors TLR7 (show TLR7 Antibodies)/8 signaling, through shedding of FcgRIIA, shifts neutrophil function from phagocytosis to a programmed necrosis pathway, neutrophil extracellular trap formation (NETosis).
Evaluation of the adjuvant effect of agonists of toll-like receptor 4 (show TLR4 Antibodies) and 7/8 in a vaccine against leishmaniasis
TLR8 coupling with SOCS-1 (show SOCS1 Antibodies) inhibits TLR7 (show TLR7 Antibodies)-mediated antiviral immunity during WNV infection in mice.
this study shows that beta,beta-dimethylacryloyl alkannin could inhibit psoriasis-activated dendritic cells via the TLR7 (show TLR7 Antibodies)/8 pathway
an important role of 2'-O-methylation for shaping differential TLR7 (show TLR7 Antibodies) or TLR8 activation
Hepatic expression of Tlr6 (show TLR6 Antibodies), but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 (show TLR6 Antibodies) and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria.
The urinary levels of Tlr8 mRNA were also higher in BXSB-Yaa mice.
TLR8 deletion accelerated autoimmunity in lupus-prone mice in response to TLR7 (show TLR7 Antibodies) activation.
TLR8 activation has direct anti-leukemic effects independent of its immunomodulating properties.
We suggest that giant cell formation may be a unique feature of TLR9 (show TLR9 Antibodies)- and TLR7 (show TLR7 Antibodies)/8-mediated macrophage activation.
These results suggest that IL-23 (show IL23A Antibodies)-driven inflammation in mouse skin may be dependent on signaling mediated by TLRs 7, 8, and 9
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Antibodies), TLR7 (show TLR7 Antibodies) and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
Knockdown TLR8 increased the apoptosis induced by Bacillus Calmette Guerin infection, and this enhanced apoptosis was caspase (show CASP3 Antibodies)-dependent.
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.
a ligand-induced dimer conformational switch is mainly responsible for TLR8 activation.
multiple regions, including ECD (show ECD Antibodies), TM, linker and TIR-tail regions of bTLR8, are involved in determining the localization of cellular ER compartment.
Porcine TLR7 (show TLR7 Antibodies) and TLR8 genes from pig lymph node tissue, were cloned and characterized.
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.