TLR8 antibody (Middle Region)

Catalog No. ABIN500964

The Rabbit Polyclonal anti-TLR8 antibody (ABIN500964) specifically detects TLR8 in WB, IF and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for TLR8 antibody (Middle Region) (ABIN500964)

Target: TLR8 (Toll-Like Receptor 8 (TLR8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-TLR8 Antibody

Binding Specificity: Middle Region

Specificity: This antibody detects CD288 / TLR8 at center.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Purification: Peptide affinity chromatography

Immunogen: TLR8 antibody was raised against a peptide corresponding to 16 amino acids near the middle of human TLR8.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 to 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TLR8

Target: TLR8 (Toll-Like Receptor 8 (TLR8))

Alternative Name: CD288 / TLR8

Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). Like TLR7, TLR8 is localized to endosomal or lysosomal compartments (6) and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA (7). Human but not murine TLR8 confers responsiveness to the antiviral compound R-848 (8).Synonyms: Toll-like receptor 8, UNQ249/PRO286

Gene ID: 51311

NCBI Accession: NP_619542

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades