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We report biallelic mutations in ATP6V1E1 (show ATP6V1E1 Proteins) and ATP6V1A, respectively encoding the E1 and A subunits of the V1 domain of V-ATPase (show ATP6V1H Proteins), as a cause of distinct metabolic and multisystemic cutis laxa entities.
V1A (show AVPR1A Proteins) subunit of V-ATPase (show ATP6V1H Proteins) has a role in the progression and prognosis of gastric cancer.
Data show that the cAMP/PKA/CREB (show CREB1 Proteins) signaling pathway initiates acidosis-induced V-ATPase (show ATP6V1H Proteins) trafficking in salivary ducts via regulation of Rab11b (show RAB11B Proteins) expression.
These data introduce Rab11b (show RAB11B Proteins) as a crucial regulator and Rip11 (show RAB11FIP5 Proteins) as mediator of acidosis-induced V-ATPase (show ATP6V1H Proteins) traffic in duct cells of submandibular gland.
there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase (show ATP6V1H Proteins) in the regulation of the proton pump
preparations of Na+,K(+)-ATPase (show ATP1A1 Proteins) isozymes from calf brain that contain catalytic subunits of three types (alpha 1, alpha 2, and alpha 3) were obtained.The real isozyme composition of the Na+ pump from the grey matter and the brain stem was determined.
Data suggest that edn1 (show EDN1 Proteins)/ednraa (show EDNRA Proteins) (endothelin-1/endothelin-1 (show EDN1 Proteins) receptor type A (show EDNRA Proteins)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.
To gain understanding of the role of Slc45a2 (show SLC45A2 Proteins) and its possible interactions with other proteins involved in melanization, the role of the V-ATPase (show ATP6V1H Proteins) as a melanosomal acidifier, was analyzed.
Total VHA-A transcript and protein, together with levels of the truncated variant, were induced by copper. The absence of a genomic sequence representing the truncated variant suggests a RNA editing event causing the production of the truncated VHA-A.
oxidative inhibition was unaffected in plants expressing VHA-A C279S and VHA-A C535S, indicating that disulfide bridges involving these cysteine residues are not essential for oxidative inhibition
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist.
ATPase, H+ transporting, lysosomal, subunit A1
, H(+)-transporting two-sector ATPase, subunit A
, H+-transporting ATPase chain A, vacuolar (VA68 type)
, V-ATPase 69 kDa subunit 1
, V-ATPase A subunit 1
, V-ATPase subunit A
, V-type proton ATPase catalytic subunit A
, vacuolar ATP synthase catalytic subunit A, ubiquitous isoform
, vacuolar ATPase isoform VA68
, vacuolar proton pump alpha subunit 1
, vacuolar proton pump subunit alpha
, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD
, ATPase, H+ transporting, lysosomal V1 subunit A
, H(+)-ATPase subunit A
, V-ATPase 69 kDa subunit
, vacuolar H+-ATPase A subunit
, 70-kDa subunit
, ATPase, H+ transporting, V1 subunit A
, ATPase, H+ transporting, V1 subunit A1
, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa
, ATPase, H+ transporting, lysosomal 70kD, V1 subunit A
, lysosomal 70kDa
, ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A, like
, ATPase, H+ transporting, lysosomal V1 subunit A, like
, A2 isoform of vacuolar H+-ATPase subunit A
, H+ ATPase
, Vacuolar ATP synthase catalytic subunit A
, V-type H+-ATPase
, vacuolar ATPase 69 kDa subunit
, vacuolar H[+] ATPase subunit 68-1
, ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A