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anti-Human HFE Antibodies:
anti-Rat (Rattus) HFE Antibodies:
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Human Monoclonal HFE Primary Antibody for ICC, ELISA - ABIN969192
Hosgood, Menashe, He, Chanock, Lan: PTEN identified as important risk factor of chronic obstructive pulmonary disease. in Respiratory medicine 2009
Show all 2 Pubmed References
Human Monoclonal HFE Primary Antibody for IF, ELISA - ABIN561252
Lenarduzzi, Hui, Yue, Ito, Shi, Williams, Bruce, Sakemura-Nakatsugawa, Xu, Schimmer, Liu: Hemochromatosis enhances tumor progression via upregulation of intracellular iron in head and neck cancer. in PLoS ONE 2013
Human Polyclonal HFE Primary Antibody for IF (p), IHC (p) - ABIN1714561
Rychtarcikova, Lettlova, Tomkova, Korenkova, Langerova, Simonova, Zjablovskaja, Alberich-Jorda, Neuzil, Truksa: Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism. in Oncotarget 2016
Studies indicate that hemochromatosis protein (HFE) variants can positively influence the immune system and might even diminish the risk of developing diseases such as amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and atherosclerosis.
unreported iron metabolism-related genes in non-classic hereditary hemochromatosis patients that were predicted to be potentially pathogenic were three novel mutations in TFR2 (show TFR2 Antibodies) [two missense (p.Leu750Pro and p.Ala777Val) and one intronic splicing mutation (c.967-1G>C)], one missense mutation in HFE (p.Tyr230Cys), and one mutation in the 5'-UTR (show UTS2R Antibodies) of HAMP (show HAMP Antibodies) gene (c.-25G>A)
GNPAT (show GNPAT Antibodies) p.D519G is strongly associated with markedly increased iron stores in p.C282Y homozygotes after correction for age, iron-related variables, and alcohol consumption
HFE p.C282Y homozygosity is significantly associated with lymphocyte and basophil counts
TFR2 (show TFR2 Antibodies) expression altered within 4h of HAMP (show HAMP Antibodies) treatment, while HFE expression altered later at 24h and 48h, suggesting that TFR2 (show TFR2 Antibodies) may function prior to HFE in HAMP (show HAMP Antibodies) regulation.
Studied association of HFE mutations on iron status among Indian beta Thalassemia carriers . A total of 100 beta thalassemia traits (BTT) with 100 normal individuals were screened for the C282Y and H63D mutations using PCR-RFLP.
Homozygosity for the HFE C282Y mutation appeared to be a strong predictor of increased iron stores and was predominantly observed in whites. The findings are consistent with the HFE C282Y mutation providing a protective effect from iron deficiency. [Review]
The goal of this study was to evaluate the impact of EHR point-of-care tools on medical record documentation of genetic testing care processes for the common HFE mutations, a thrombophilia panel, and HLA-B27.
HFE mRNA was independently elevated by extracellular and intracellular iron-excess. Thus, it may be involved in sensing both, extracellular and intracellular iron.
Diagnostic value of targeted next-generation sequencing in suspected hemochromatosis patients with a single copy of the HFE p.Cys282Tyr causative allele.
H67D mutation in HFE gene is associated with decreased susceptibility to manganese accumulation in the brain and neurotoxicity induced by inhaled manganese.
the aging HFE KO mouse on an SV129 genetic background has the potential to facilitate the investigation of cardiomyopathy induced by HFE gene mutations.
unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.
Single Hjv (show HFE2 Antibodies)(-)/(-) and double Hfe(-)/(-)Hjv (show HFE2 Antibodies)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (show HFE2 Antibodies) regulate hepcidin (show HAMP Antibodies) via the same pathway.
Results show that HFE requires HJV (show HFE2 Antibodies) to activate downstream signal transduction pathways for hepcidin (show HAMP Antibodies) regulation.
Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.
results provide evidence that HFE induces hepcidin (show HAMP Antibodies) expression via the BMP pathway: HFE interacts with ALK3 (show BMPR1A Antibodies) to stabilize ALK3 (show BMPR1A Antibodies) protein and increase ALK3 (show BMPR1A Antibodies) expression at the cell surface.
These results support in vivo studies which suggest that Hfe and Tfr2 (show TFR2 Antibodies) can independently regulate hepcidin (show HAMP Antibodies).
A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.
Hfe-knockout mice did not have higher brain iron levels than wildtype controls.
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
MHC class I-like protein HFE
, hereditary hemochromatosis protein
, hereditary hemochromatosis protein HLA-H
, high Fe
, hereditary hemochromatosis protein homolog
, hemochromatosis protein