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anti-Mouse (Murine) SLC39A6 Antibodies:
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Cow (Bovine) Polyclonal SLC39A6 Primary Antibody for IHC, WB - ABIN2781630
Trokovic, Pöllänen, Porola, Stegaev, Hetzel, Tivesten, Engdahl, Carlsten, Forsblad-dElia, Fagman, Lagerquist, Konttinen: Exosomal secretion of death bullets: a new way of apoptotic escape? in American journal of physiology. Endocrinology and metabolism 2012
results establish a molecular link between STAT3, LIV1 and Snail in epithelial-mesenchymal transition in gastrula organizer; LIV1 is essential for the nuclear localization of zinc-finger protein Snail
PrP and ZIP6 inherited the ability to interact with NCAM1 from their common ZIP ancestors but have since diverged to control distinct posttranslational modifications of NCAM1.
Zip 6 dysregulation was involved in enhanced inflammation during aging.
mice fed low-Zn diet had reduced number of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells compromised seminiferous tubule structure, and reduced Zip10 and Zip6 abundance (>50%; P < 0.5) compared with control diet
ZIP6 deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 expression is strongly associated with resistance to hypoxia.
SLC39A6 promotes aggressiveness of esophageal carcinoma cells by increasing intracellular levels of zinc, activating phosphatidylinositol 3-kinase signaling, and up-regulating genes that regulate metastasis.
Upregulation of SLC39A6 is associated with hepatocellular carcinoma.
SLC39A6 may have a tumor promoting role in esophageal carcinoma
Knock-down of ZIP6 but not ZIP7 in MIN6 beta cells impaired the protective effects of GLP-1 on fatty acid-induced cell apoptosis, possibly via reduced activation of the p-ERK pathway
drug resistance of ovarian cancer cells to trichostatin A may be related to expression of the LIV1 gene
Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes.
a causative role for ZIP6 in cell motility and migration
Down-regulated LIV-1 cells showed significant inhibition of proliferation in vitro and reduction of tumor growth in vivo. Furthermore, E-cadherin expression increased in LIV-1 siRNA expressing Hep-G2.
SLC39A6 has an important role in the prognosis of esophageal squamous-cell carcinoma and may be a potential therapeutic target.
Some studies correlate LIV-1 expression with a more aggressive cancer phenotype and increased likelihood for metastasis to lymph nodes. In contrast, other evidence suggests this transporter is associated with a more favorable prognosis. [review]
The results of this study showed evidence for a positive correlation between LIV1 and ZnT6 insuperior temporal, occipital, and frontal gyri in patient with alzheimer disease.
LIV-1 is involved in prostate cancer progression as an intracellular target of growth factor receptor signaling which promoted EMT and cancer metastasis
LIV-1 mRNA upregulation is associated with the progression of cervical cancer but not with the development of endometrial carcinoma.
The present study identifies LIV1 as a critical mediator responsible for HDACi-induced apoptosis. The effect of LIV1 is, at least in part, mediated by affecting intracellular zinc homeostasis.
Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role.
Structure-function analysis of LIV-1.
data suggest that LIV-1 protein is a promising candidate for a novel marker for breast cancer patients with better outcome
regulation of LIV-1 protein in human breast cancer xenografts
Hence, our data provide the first evidence that LIV-1 mRNA is overexpressed in cervical cancer in situ and is involved in invasion of cervical cancer cells through targeting MAPK-mediated Snail and Slug expression.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003
zinc transporter ZIP6
, solute carrier family 39 (zinc transporter), member 6
, zrt- and Irt-like protein 6
, solute carrier family 39 member 6
, solute carrier family 39, member 6
, endoplasmic reticulum membrane protein
, endoplasmic reticulum membrane-linked protein
, LIV-1 protein, estrogen regulated
, estrogen-regulated protein LIV-1
, solute carrier family 39 (metal ion transporter), member 6
, estrogen-regulated LIV-1 protein