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Cow (Bovine) Polyclonal SLC39A7 Primary Antibody for WB - ABIN2781567
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Slc39a7/zip7 plays a critical role in development and zinc homeostasis in zebrafish.
ZIP7 may be essential for the control of endoplasmic reticulum (ER) localized zinc and mechanisms that disrupt this process may lead to ER-stress and contribute to insulin resistance (IR).
Data indicate a form of autosomal recessive agammaglobulinemia caused by hypomorphic mutations in the endoplasmic reticulum-to-cytoplasmic zinc transporter solute carrier family 39 (zinc transporter), member 7 (ZIP7).
Genetic ablation of ZIP7 results in decreased levels of cytosolic zinc, increased endoplasmic reticulum zinc levels, and induction of endoplasmic reticulum stress.
Results suggest that solute carrier family 39 (zinc transporter), member 7 (SLC39A7) plays a crucial role in the proliferation and survival of colorectal cancer cells, which associates with colorectal tumorigenesis.
These data reveal the role of ZIP7-mediated zinc release from intracellular stores in driving major pathways, such as MAPK, mTOR and PI3K-AKT, involved in providing cell survival and proliferation and often over activated in cancer.
The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7.
Knock-down of ZIP6 but not ZIP7 in MIN6 beta cells impaired the protective effects of GLP-1 on fatty acid-induced cell apoptosis, possibly via reduced activation of the p-ERK pathway
The connection with proliferation and migration, as well as the activation of ZIP7 by CK2, a kinase that is antiapoptotic and promotes cell division
Structure-function analysis of HKE4, a zinc transporter.
ZIP7 is a functional zinc transporter that acts by transporting zinc from the Golgi apparatus to the cytoplasm of the cell
ZIP7 is a critical component in the redistribution of zinc from intracellular stores to the cytoplasm and, as such, is essential for the zinc-induced inhibition of phosphatases, which leads to activation of growth factor receptors in MCF-7 cells
ZIP7 releases zinc from the endoplasmic reticulum and might be required for tyrosine kinase activation.
the useful information for the characterization of SLC39A7 gene and potential association with carcass traits in pigs
these findings provide evidence for the importance of ZIP7 in maintenance of intestinal epithelial homeostasis through the regulation of ER function in proliferative progenitor cells and maintenance of intestinal stem cells. Therapeutic targeting of ZIP7 could lead to effective treatment of gastrointestinal disorders.
a novel role for Zip7 in glucose metabolism in skeletal muscle
Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells.
Overexpression of HvZIP7 in barley plants increased Zn uptake when moderately high concentrations of Zn were supplied....HvZIP7 displays characteristics of low-affinity Zn transport.
The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Two transcript variants encoding the same protein have been found for this gene.
zinc transporter Slc39a7
, solute carrier family 39 member 7
, histidine-rich membrane protein Ke4
, solute carrier family 39 (zinc transporter), member 7
, zinc transporter SLC39A7
, HLA class II region expressed gene KE4
, Ke4 gene, mouse, human homolog of
, really interesting new gene 5 protein
, solute carrier family 39, member 7
, H2-K region expressed gene 4
, Histidine-rich membrane protein
, RT1 class I, locus Ke4
, RT1 region expressed gene KE4