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A model is developed whereby transferrin-binding protein (Tbp)B delivers transferrin to TbpA, which completes the iron removal and transport process.
identified polymorphisms of transferrin on a panel of 10 different pig breeds.
Results indicate that transferrin (Tf) is an inducible immune effector molecule that may play an important role in pathogen clearance of insect innate immunity.
High transferrin expression is associated with Spontaneous intracranial hypotension.
rs4525863, rs1880669, and rs2692695 SNPs of the TF gene might be a protective factor for ischemic stroke in Southern Chinese Han population.
our data establish that blood TSAT exerts a critical role in experimental stroke-induced brain damage. In addition, our findings suggest that the protective effect of iron-free transferrin (apotransferrin, ATf) at the neuronal level resides in preventing NMDA-induced HTf uptake and ROS production, which in turn reduces neuronal damage
Histochemical staining with anti-Tf antibody and an N-acetylglucosamine-binding lectin suggests that brain-type Tf is secreted from choroid plexus, CSF-producing tissue
Data suggest that serum levels of biomarkers of iron status (ferritin, transferrin, and hemoglobin) are positively associated with risk of hyperuricemia in Chinese adults.
Transfeerrin saturation was associated with less severe anemia in early CKD patients.
Three single nucleotide polymorphisms associated with iron regulation were genotyped in multiple sclerosis : two in the human hereditary hemochromatosis protein gene HFE: rs1800562 (C282Y mutation) and rs1799945 (H63D mutation), as well as the rs1049296 SNP in the transferrin gene (C2 mutation). We only observed a higher prevalence of TF-C2 in multiple sclerosis patients
Increased serum transferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes has been reported.
model predicts that small vesicles promote activation of FX by the extrinsic tenase (VIIa/TF) significantly better than large vesicles
This work presents an HPLC analysis of carbohydrate-deficient transferrin.
Transferrin associated with Adenoid Cystic Carcinoma of Parotid Gland in immunohistochemical study, was found up-regulated in Pleomorphic Adenoma of the Parotid Gland.
The RNAi knock-down of Trypanosoma brucei GSK3beta reduced Tf endocytosis.
holotransferrin treatment to recombinant-TfR1 HepG2 cells did not elevate HAMP responses compared to untreated or wild-type cells. In
The subgroup of Parkinson's disease (PD) patients shows higher levels of CSF alpha-synuclein than the rest, indicating that PD includes two subgroups, which differ in levels of brain-type transferrin and alpha-synuclein. (Review)
Blood lead levels were positively associated with plasma homocysteine levels measured 4-6 years later, and three SNPs in the TF gene modified the association.
In this technical note, the aberrant glycosylation profiles of transferrin glycoforms in congenital disorder of glycosylation patients are presented to shed light on the Mass Spectrometry of native transferrin and glycopeptides from the viewpoint of clinical glycoproteomics.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
High carbohydrate deficient transferrin is associated with relapse in alcohol-dependent patients.
High Plasma Carbohydrate-deficient transferrin is associated with monoclonal light chain gammopathy.
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
The TF gene has an effect on milk fat yield.
Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38.
Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor.
Together, these data indicate that Lcn2, in combination with transferrin, confines Klebsiella pneumoniae to the airways and prevents invasion into tissue containing the pulmonary vasculature.
Transferrin(hpx/hpx) Hemojuvelin(+/+) and Transferrin(hpx/hpx) Hemojuvelin(-/-) phenotypes did not differ markedly, but RBC transfusions increased hepcidin levels in Transferrin(hpx/hpx) Hemojuvelin(+/+) but not Transferrin(hpx/hpx) Hemojuvelin(-/-)mice.
These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice.
Neurodegenerative conditions involving iron-mediated toxicity may be due to a failure of iron transport or storage mechanisms, rather than to the presence of high levels of non-transferrin-bound iron.
Apotransferrin mitigates the neurotoxicity of hemoglobin in a cell culture model of intracerebral hemorrhage.
Descibed is the 2.4 A structure of inhibitor of carbonic anhydrase from a pseudomerohedral twinned crystal: a member of the transferrin superfamily.
transferrin receptor 2 and HFE are involved in holotransferrin-dependent signaling for the regulation of furin which involved Erk phosphorylation. Furin in turn may control hepcidin expression.
hepcidin expression in hypotransferrinemic mice is regulated both by transferrin-restricted erythropoiesis and by transferrin through a mechanism independent of its role in erythropoiesis
These data show that mycobacteria reside in the Rab11(+) endocytic recycling pathway, thereby retaining access to metabolizing transferrin and avoiding endocytosed immunoproteins like Lcn2.
during later times postinfection (1.5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome
Transsferrin overexpression has negative effects on testicular function and that transfserrin levels require strict regulation in the testis.
developing erythroid cells, which are taking up vast amounts of Fe, deliver the metal directly from transferrin-containing endosomes to mitochondria
The role of transferrin in glial protection was investigated.
Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery.
transferrin mRNAs in zebrafish were first expressed at approximately 7 hours postfertilization (hpf) in the yolk syncytial layer and later in the liver rudiment (48 hpf) and in the esophagus transiently (72-96 hpf)
The zebrafish hypochromic anemia mutant, gavi, exhibits transferrin deficiency due to mutations in transferrin-a.Transferrin-a plays a critical role both in iron transport & in regulating hepcidin expression in zebrafish embryos.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5.
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.
beta-1 metal-binding globulin
, Beta-1-metal-binding globulin
, allergen Gal d III
, ovotransferrin BB type
, ovotransferrin BC type
, ovotransferrin CC type
, serum transferrin
, serotransferrin B
, hypotransferrinemia with hemochromatosis
, liver regeneration-related protein LRRG03
, transferrin 1
, transferrin precursor
, T-cell replacing factor
, eosinophil differentiation factor
, prepro-thyrotropin-releasing hormone
, pro-thyrotropin-releasing hormone
, thyrotropin releasing hormone
, STF I
, Serotransferrin I
, Siderophilin I
, serotransferrin I
, siderophilin I