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Human Polyclonal GRLF1 Primary Antibody for IHC (p), IHC - ABIN408537
Eberwein, Laird, Schulz, Reinhard, Steinberg, Tomakidi: Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors. in Biochimica et biophysica acta 2015
Human Polyclonal GRLF1 Primary Antibody for IHC (p) - ABIN5579387
Li, Li, Zhou, Wang, Wang, Zhao, Cui, Ren, Dong, Chen: Abnormal expression of p190RhoGAP in colorectal cancer patients with poor survival. in American journal of translational research 2016
report association of APOE (show APOE Antibodies) and TOMM40 (show TOMM40 Antibodies) with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 (show SERPINA1 Antibodies) with progressive non-fluent aphasia.
interaction involves the first FF motif of p190A and the winged helix/PCI (show SERPINA5 Antibodies) domain of eIF3A (show EIF6 Antibodies), is enhanced by serum stimulation and reduced by phosphatase treatment
these data demonstrate that a complex of p190RhoGAP-A and anillin (show ANLN Antibodies) modulates RhoA (show RHOA Antibodies)-GTP (show AK3 Antibodies) levels in the cytokinetic furrow to ensure progression of cytokinesis.
These results place Blk (show BLK Antibodies) upstream of the p190RhoGAP-RhoA (show RHOA Antibodies) pathway in Galpha13 (show GNA13 Antibodies)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Antibodies)-triggered invasion.
ARHGAP35 rs1052667 polymorphism was an independent prognostic factor influencing the survival of osteosarcoma.
GRF-1 expression may modify osteosarcoma prognosis and may be a potential tumor therapeutic target.
A ubiquitous binding partner of p190RhoGAP, p120RasGAP (RasGAP (show RASA1 Antibodies)), is expressed in much lower levels in DKO4 cells compared to DLD1, and this expression is regulated by KRAS.
Overexpression of p190 (show CNTNAP1 Antibodies) mRNA associated with lung adenocarcinoma.
These data suggest that the interaction of human papillomavirus E7 with p190 dysregulates this GTPase activating protein and alters the actin cytoskeleton.
RhoA (show RHOA Antibodies) is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis.
p190A acts as a modulator of Rho GTPases in a localized area around the cilia to permit the dynamic actin rearrangement required for cilia elongation.
The cellular RacGAP activity of p190RhoGAP requires an intact polybasic region adjacent to the GAP domain whereas the RhoGAP (show ARHGAP1 Antibodies) activity is inhibited by the same domain.
study demonstrates that the epidermal growth factor receptor (EGFR (show EGFR Antibodies)) cooperates with beta3 integrin (show ITGB3 Antibodies) to regulate p190RhoGAP activity in mammary gland epithelial cells
p190RhoGAP links integrins and caveolin-1 (show CAV1 Antibodies)/caveolae to RhoA (show RHOA Antibodies) in a mechanotransduction cascade that participates in endothelial adaptation to flow.
In a novel knockout mouse strain p190RhoGAP does not play a major, indispensable role in integrin signaling of neutrophils.
Cdh1 (show CDH1 Antibodies) formed a physical complex with p190 (show CNTNAP1 Antibodies) and stimulated the efficient ubiquitination of p190 (show CNTNAP1 Antibodies), both in in vitro and in vivo.
identified the serum-responsive transcriptional regulator TFII-I (show GTF2I Antibodies) as a specific interactor with the p190 RhoGAP FF domains
p190 transiently associates with plexins, and its RhoGAP activity is increased in response to semaphorin stimulation. We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins.
FAK (show PTK2 Antibodies)-induced down-modulation of RhoA (show RHOA Antibodies) activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability
Rac (show AKT1 Antibodies) activation links diverse signaling systems to adherens junction assembly by controlling transient p190RhoGAP interactions with p120 (show CTNND1 Antibodies) and localized inhibition of Rho.
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
glucocorticoid receptor DNA binding factor 1
, glucocorticoid receptor DNA-binding factor 1
, glucocorticoid receptor repression factor 1
, rho GAP p190A
, rho GTPase-activating protein 35
, P190 RhoGAP
, GAP-associated protein p190
, Rho GTPase activating protein 35 L homeolog
, rho GTPase activating protein 35 L homeolog