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anti-Human IRX1 Antibodies:
anti-Mouse (Murine) IRX1 Antibodies:
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Human Polyclonal IRX1 Primary Antibody for ELISA, WB - ABIN566348
Zougman, Mann, Wisniewski: Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. in Nucleic acids research 2011
Show all 3 Pubmed References
A total of three nonsynonymous mutations (p.Gln240Glu, p.Ser298Asn and p.Ala381Glu) of the IRX1 (show IRX3 Antibodies) gene were verified in 215 nonsyndromic congenital heart disease patients.
Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy.
this is the first genome-wide association study of Rheumatoid Factor positivity in Rheumatoid Arthritis. Variation at the IRX1 (show IRX3 Antibodies) locus on chromosome 5p15.3 is associated with the presence of Rheumatoid Factor. Our findings indicate that IRX1 (show IRX3 Antibodies) and HLA-DRB1 (show HLA-DRB1 Antibodies) are the strongest genetic factors for Rheumatoid Factor production in Rheumatoid Arthritis.
the association between FTO and obesity appears to be due to its influence on expression of IRX3 [Figure 1]. Genetic studies indicated FTO as an important gene for obesity risk in various populations but the recent developments suggest that obesity-associated FTO SNPs have long-range interactions with IRX3.
Downregulation of miR (show MLXIP Antibodies)-377 may contribute to the upregulation of IRX3 in HCC (show FAM126A Antibodies).
This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.
In osteosarcoma cells and lines, IRX1 (show IRX3 Antibodies) overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice.
Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis.
Findings suggest that methylation-associated down-regulation of EBF3 (show MAPRE3 Antibodies) and IRX1 (show IRX3 Antibodies) genes may play an important role in a pathogenic effect of TGF-beta (show TGFB1 Antibodies) on RASFs.
data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO (show FTO Antibodies) and represents a novel determinant of body mass and composition
Irx1 regulates Foxj1 (show FOXJ1 Antibodies) and Sox9 (show SOX9 Antibodies) to control cell differentiation during development.
This homeobox protein (show HOXA1 Antibodies) is expressed during early lung development.
This homeobox protein (show HOXA1 Antibodies) is expressed during digit development and is an early marker for this development.
Observations suggest that Irx2 (show IRX2 Antibodies) functions downstream of irx1a to control shh (show SHH Antibodies) expression in the retina. Study proposed a novel transcriptional cascade of ath5 (show ATOH7 Antibodies)-irx1a-irx2a in the regulation of hedgehog (show SHH Antibodies) waves during vertebrate retinal development.
Data revealed that expression of DNA binding inhibitor 3 (show PPP1R11 Antibodies), early B cell factor 2 (show EBF2 Antibodies), Ebf3 (show EBF3 Antibodies), Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 (show MAB21L1 Antibodies) , fatty acid binding protein 7 (show FABP7 Antibodies) and stathmin-like 4 (show STMN4 Antibodies),were enriched in the diencephalon of zebrafish.
Our results reveal a role for Iroquois genes in controlling hedgehog (show SHH Antibodies) expression during vertebrate retinogenesis.
irx1a is not required for the initial specification but it is required for the complete differentiation of 5HT (show DDC Antibodies) neurons
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13.
homeodomain protein IRXA1
, iroquois homeobox protein 1
, iroquois-class homeodomain protein IRX-1
, iroquois homologue-1
, iroquois homeobox 1
, iroquois-class homeodomain protein irx-1
, Iroquois related homeobox 1
, Iroquois homeobox protein 1-A
, homeobox Iro protein
, iroquois-class homeodomain protein irx-1-A
, LOW QUALITY PROTEIN: iroquois-class homeodomain protein IRX-1