Browse our anti-VHL (VHL) Antibodies

Human Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) interaction partners

1. Low VHL expression is associated with papillary thyroid carcinoma.

2. that the reduced expression of LimD1 (show LIMD1 Antibodies) and VHL might have synergistic effect on induction of HIF1alpha (show HIF1A Antibodies) resulting increased cellular proliferation and progression of the disease.

3. A two-hit loss involving VHL predicted for clear-cell renal cell carcinoma (show MOK Antibodies)(ccRCC ) and a better prognosis, whereas mutations in PTEN, TP53 (show TP53 Antibodies), or RELN (show RELN Antibodies) predicted for Sarcomatoid clear-cell renal cell carcinoma (show MOK Antibodies) and worse prognosis.

4. we report a rare case of renal-cell carcinoma (show MOK Antibodies) and hereditary polycythemia. Genotyping revealed that the patient carried both a germline HIF2A (show EPAS1 Antibodies) mutation and a somatic VHL mutation. Both mutations result in overactivation of HIF2A (show EPAS1 Antibodies) and its downstream target genes

5. The co-transfection of VHL and PLN in HEK293 cells decreas (show PLN Antibodies)ed PLN expression under oxidative stress, whereas knockdown of VHL increased PLN expression both under normal and oxidative stress conditions.

6. missense mutations in the VHL gene during sporadic CCRCC were studied to evaluate their specific localization in relation to binding sites for the proteins interacting with VHL.

7. epigenomic profiling of clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC) establishes a compendium of somatically altered cis (show CISH Antibodies)-regulatory elements, uncovering new potential targets including ZNF395 (show ZNF395 Antibodies). Loss of VHL, a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a (show EPAS1 Antibodies) and recruitment of histone acetyltransferase p300 (show EP300 Antibodies) at preexisting lineage-specific promoter-enhancer complexes

8. Biochemical analyses demonstrate that Daam2 associates with VHL and facilitates its ubiquitination and degradation.

9. VHLdb presently contains 478 interactors, of which 117 have been manually curated, and 1,074 mutations. This makes it the largest available database for pVHL-related information

10. A mouse model based on concurrent ectopic expression of constitutively active Notch1 (show NOTCH1 Antibodies) (NICD1) and deletion of the Vhl gene show the existence of nests of dysplastic cells in the kidney with a clear cytoplasm as a consequence of lipid accumulation, thus displaying a one important hallmark of human clear cell renal cell carcinoma (show MOK Antibodies).

Fruit Fly (Drosophila melanogaster) Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) interaction partners

1. Interaction between Nm23 (show NME1 Antibodies) and the tumor suppressor VHL

2. Transgenic pVHL can fully maintain normal dVHL-HIF1-alpha (show HIF1A Antibodies) downstream pathways in flies.

3. Codepletion of Vhl with Mgr (show GRHL1 Antibodies) gives partial rescue of tubulin (show TUBB Antibodies) instability, monopolar spindle formation, and loss of centrosomes.

4. The results establish a developmental function of the VHL gene that is relevant to its tumor-suppressor activity.

5. findings reveal a second type of tracheal hypoxic response in which Sima activation conflicts with developmental tracheogenesis, and identify the dVHL and ago ubiquitin ligases as key determinants of hypoxia sensitivity in tracheal cells

Zebrafish Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) interaction partners

1. the vhl(-/-) zebrafish kidney is characterized by an increased tubule diameter, disorganized cilia, the dramatic formation of cytoplasmic lipid vesicles, glycogen (show GYS2 Antibodies) accumulation, aberrant cell proliferation and abnormal apoptosis.

2. In this review, we have tried to bring together knowledge on the HIF/hypoxic signaling pathway in zebrafish, including what is known on VHL functions.

3. by modulating hypoxia-inducible factor activity via up-regulation of VHL, FOXO3a (show FOXO3 Antibodies) (foxo3b) plays an important role in survival in response to hypoxic stress.

4. Zebrafish embryos lacking endogenous vhl lead to defective phenotypes in the renal system that were characterized by the curved and cystic pronephric tubule or/and a cystic and malformed glomerulus.

5. Inhibiting PHD (show PDC Antibodies) or knocking down VHL rescues Methyl tert (show TERT Antibodies)-butyl ether induced vascular lesions.

6. Zebrafish vhl mutants display a marked increase in blood vessel formation throughout the embryo, and the most severe neovascularization is observed in distinct areas that overlap with high vegfa (show VEGFA Antibodies) mRNA expression, including the vhl mutant brain and eye.

7. Vhl mutants develop polycythemia with increased epo (show EPO Antibodies)/epor (show EPOR Antibodies) mRNA & erythropoietin (show EPO Antibodies) signaling. VHL regulates hematopoiesis & erythroid differentiation. Zebrafish vhl mutants are the 1st congenital embryonic viable systemic vertebrate animal model for VHL.

Mouse (Murine) Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) interaction partners

1. Oxidative stress upregulates pVHL expression to induce PLN (show PLN Antibodies) degradation in failing hearts.

2. Loss of VHL could be driving tumour cell dissemination through stabilization of HIF-1alpha (show HIF1A Antibodies) in a murine renal-cell carcinoma (show MOK Antibodies) model. Overexpression of HIF-1alpha (show HIF1A Antibodies)-regulated genes that are upregulated in our VHL knockout cells signifies an aggressive form of clear-cell renal-cell carcinoma (show MOK Antibodies).

3. We conditionally targeted Bap1 (show BAP1 Antibodies) and Pbrm1 (show PBRM1 Antibodies) (with Vhl) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC)origins

4. dual inactivation of Vhl with either Bap1 (show BAP1 Antibodies) or Pbrm1 (show PBRM1 Antibodies) results in faithful genetically engineered murine models of clear cell renal cell carcinoma (show MOK Antibodies) (ccRCC).

5. HIF-1alpha (show HIF1A Antibodies)-dependent, HIF-2alpha (show EPAS1 Antibodies)-independent angiogenesis and constitutive diuresis is caused by Vhl deletion in renal epithelia

6. HIF-1alpha (show HIF1A Antibodies)/miR (show MLXIP Antibodies)-210 pathway is strongly activated in VHL mutated paragangliomas, weakly activated in SDHx mutated PGLs (show PGLS Antibodies), and not activated in VHLdel- and SDHxwt/VHLwt-PGLs (show PGLS Antibodies).

7. kidney-specific deletion of Vhl and Pbrm1 (show PBRM1 Antibodies), but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.

8. Codeletion of VHL together with HIF2A (show EPAS1 Antibodies) but not with HIF1A (show HIF1A Antibodies) led to apparently normal kidneys, and the animals reached normal age but were anemic because of low erythropoietin (show EPO Antibodies) levels. Stromal deletion of HIF2A (show EPAS1 Antibodies) or HIF1A (show HIF1A Antibodies) alone did not affect kidney development.

9. High VHL expression is associated with liver fibrosis.

10. Study demonstrated that mice with a loss of one allele of the VHL gene exhibited normal phenotypes without evidence of predisposition to the development of CNS-hemangioblastomas. Heterozygous VHL +/- mice exhibited the neuroprotective response to acute cerebral ischemia/reperfusion injury due to enhanced angiogenesis by HIF-dependent regulation and HIF-independent Twist 1 (show TWIST1 Antibodies) signaling.