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VHL antibody (AA 1-172)
VHL
Reactivity: Human
WB, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-VHL Antibody
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Target
See all VHL Antibodies
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Binding Specificity
All epitopes for VHL antibodies
AA 1-172
Reactivity
All reactivities for VHL antibodies
Human
Host
All hosts for VHL antibodies
Rabbit
Clonality
All clonalities for VHL antibodies
Polyclonal
Conjugate
All conjugates for VHL antibodies
This VHL antibody is un-conjugated
Application
All applications for VHL antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Sequence
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRVYTLKER CLQVVRSLVK PENYRRLDIV RSLYEDLEDH PNVQKDLERL TQERIAHQRM GD
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human VHL (NP_937799.1).
Isotype
IgG
Top Product
Discover our top product VHL Primary Antibody
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze / thaw cycles
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
References for anti-VHL antibody (ABIN3020968)
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Liu, Cai, Hu, Mei, Zhang, Ouyang, Wang, Zhang, Xiao : "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). " in: The Journal of biological chemistry , Vol. 291 , Issue 49 , pp. 25692-25705 , (2017 ) (PubMed ).
Du, Zhang, Zhang, Ouyang, Wang, Liu, Li, Ji, Liu, Xiao : "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. " in: Journal of immunology (Baltimore, Md. : 1950) , Vol. 195 , Issue 4 , pp. 1782-90 , (2015 ) (PubMed ).
Wang, Zhang, Ji, Liu, Ouyang, Xiao : "The von hippel-lindau protein suppresses androgen receptor activity. " in: Molecular endocrinology (Baltimore, Md.) , Vol. 28 , Issue 2 , pp. 239-48 , (2015 ) (PubMed ).
Target Details for VHL
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Target
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Alternative Name
VHL (VHL Products )
Synonyms
HRCA1 antibody, RCA1 antibody, VHL1 antibody, pVHL antibody, BcDNA:RH61560 antibody, CG13221 antibody, DVhl antibody, Dmel\\CG13221 antibody, Dvhl antibody, VHL antibody, d-VHL antibody, d-vhl antibody, dVHL antibody, dmVHL antibody, vhl antibody, rca1 antibody, vhl1 antibody, hrca1 antibody, zgc:158722 antibody, Vhlh antibody, von Hippel-Lindau tumor suppressor antibody, von Hippel-Lindau antibody, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase antibody, von Hippel-Lindau disease tumor suppressor antibody, VHL antibody, Vhl antibody, vhl antibody, CpipJ_CPIJ009992 antibody
Background
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.,VHL,HRCA1,RCA1,VHL1,pVHL,PVHL,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Cell differentiation,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,Cardiovascular,Angiogenesis,VHL
Molecular Weight
18 kDa/19 kDa/24 kDa
Gene ID
7428
UniProt
P40337
Pathways
Tube Formation , Signaling Events mediated by VEGFR1 and VEGFR2 , Ubiquitin Proteasome Pathway
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