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data presented in this study characterize UXT as a novel repressor of Notch (show NOTCH1 Proteins) signaling, shedding new light on the molecular regulation of angiogenesis.
Our study has revealed the first in vivo function for UXT in the mammalian germline as a regulator of distinct transcriptional programs in SSCs and differentiating spermatogonia.
UXT Is a LOX (show LOX Proteins)-PP Interacting Protein That Modulates Estrogen Receptor Alpha (show ESR1 Proteins) Activity in Breast Cancer Cells.
UXT-V1 represents a novel integral component of the MAVS (show MAVS Proteins) signalosome on mitochondria, mediating the innate antiviral signal transduction.
these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB (show NFKB1 Proteins) pathway.
Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF (show TNF Proteins)-induced apoptosis. It protects cells against TNF (show TNF Proteins)-induced apoptosis through modulating complex II formation.
Uxt is a novel and essential cofactor in the NF-kappa B (show NFKB1 Proteins) transcriptional enhanceosome.
EZH1 (show EZH1 Proteins), SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus.
we describe the identification of UXT as a novel MDMX (show MDM4 Proteins)-interacting protein
UXT is a binding protein of PIAS2 (show PIAS2 Proteins), and interaction between PIAS2 (show PIAS2 Proteins) and UXT may be important for the transcriptional activation of AR.
Art27 interacts with GATA4 (show GATA4 Proteins), FOG2 and NKX2.5 (show NKX2-5 Proteins) and is a novel co-repressor of cardiac genes.
Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype.
VHL (show VHL Proteins)-UXT interaction and VHL (show VHL Proteins)-induced ubiquitination of androgen receptor(AR (show AR Proteins)) regulate transcriptional activation of the AR.
Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM (show SARM1 Proteins)-induced apoptosis.
Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB (show NFKB1 Proteins) transactivation through phosphorylation of coactivator UXT
Loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression, and nuclear ART-27 expression was lost in the majority of AR-positive recurrent prostate cancers.
The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, ubiquitously-expressed transcript
, ubiquitously expressed transcript protein
, SKP2-associated alpha PFD 1
, androgen receptor trapped clone 27 protein