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Sk1 and Sk2 (show KCNN2 Proteins) are not redundant in biological function and are essential for diverse physiological functions in Drosophila
findings indicate a role of SPHK1 in modulating FB1 (show TFPT Proteins)-triggered cell death via SA and JA pathway interactions.
SPHK/phyto-S1P (show MBTPS1 Proteins) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
Melatonin administration significantly inhibited those changes and induced a decreased immunoreactivity for rabbit hemorrhagic disease virus VP60 antigen in the liver. Results obtained indicate that the SphK1/S1P (show MBTPS1 Proteins) system activates in parallel to viral replication and the inflammatory process induced by the virus.
siRNA-mediated knockdown of Sphk2 (show SPHK2 Proteins) but not SphK1 resulted in a reduction of cargo content in purified exosomes
These findings suggested that miR125b may regulate Alzheimer's disease (AD), and neuronal cell growth and apoptosis, via the regulation of inflammatory factors and oxidative stress by SphK1; therefore, miR125b may be involved in the development of AD.
these findings suggest that SphK1 may play a pivotal role in HER2 (show ERBB2 Proteins)-positive breast carcinogenesis
Authors found that elevated levels of pSphK1 were positive correlation with high expression of S1P (show MBTPS1 Proteins), which in turn promoted metastasis of TNBC through S1P (show MBTPS1 Proteins)/S1PR3 (show S1PR3 Proteins)/Notch (show NOTCH1 Proteins) signaling pathway.
SphK1 may be novel targets for inhibiting lymph node metastasis in esophageal squamous cell carcinoma.
Butyrate and bioactive proteolytic form of Wnt-5a (show WNT5A Proteins) regulate colonic epithelial proliferation and spatial development
Immunohistochemistry of xenograft tumors showed significant enhancement of caspase-3 (show CASP3 Proteins) cleavage and suppression of Ki67 (show MKI67 Proteins) and phospho-EGFR (show EGFR Proteins) by the drug combination, but SphK1 downregulation occurred only in MDA-MB-468 tumors, so is unlikely to be integral to treatment efficacy
Data show that sphingosine kinase 1 (SPHK1) was significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and low levels of sphingosine-1-phosphate lyase 1 (SGPL1 (show SGPL1 Proteins)) mRNA correlated with a worse overall survival, and that sphingosine-1-phosphate receptor 2 (S1PR2 (show S1PR2 Proteins)) is over-expressed in a subset of tumours, which in part mediates sphingosine 1-phosphate (S1P (show MBTPS1 Proteins))-induced migration of OSCC cells.
SphK1 expression regulates the early stage of colon carcinogenesis and tumor growth, thus inhibition of SphK1 may be an effective strategy for colon cancer chemoprevention.
the blockage of SPHK1 activity to attenuate autophagy may be a promising strategy for the prevention and treatment of patocellular carcinoma
vascular transcriptome analysis shows that S1P (show S1PR1 Proteins) pathway is critical in the regulation of vascular function in AngII-induced hypertension, although Sphk1 may have opposing roles in the regulation of vasoconstriction and endothelium-dependent vasorelaxation.
The cell division gene PCNA (show PCNA Proteins) was significantly overexpressed in SK2 (show PAPSS2 Proteins)(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase (show UGCG Proteins).
Studied role of microglial cells in inflammation via a Toll-like receptor 2 (TLR2)-->sphingosine kinase 1 (Sphk1)-->pro-inflammatory cytokine pathway in cerebral ischemia/reperfusion (I/R).
SphK1 is involved in maladaptive hypertrophy and we propose that heart failure might be an additional direct target for therapeutic intervention with SphK1 inhibitors.
These results suggest that SphK1 expression plays a pivotal role in the early stages of colon carcinogenesis
the recruitment of Sphk1 to sphingosine-enriched endocytic vesicles and the generation of sphingosine-1-phosphate facilitate membrane trafficking along the endosomal pathway.
SK1 activation is renoprotective via induction of autophagy in the fibrotic process
donor islets from mice deficient in Sphk1 KO contain a reduced number of resident intraislet vascular endothelial cells. The main product of Sphk1, sphingosine-1-phosphate, controls the migration of intraislet endothelial cells in vitro. In vivo, Sphk1 knockout islets have an impaired ability to cure diabetes compared with wild-type controls.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1