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anti-Human DKK1 Antibodies:
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Human Monoclonal DKK1 Primary Antibody for IHC (p), IP - ABIN524880
DAmelio, Roato, DAmico, Veneziano, Suman, Sassi, Bisignano, Ferracini, Gargiulo, Castoldi, Pescarmona, Isaia: Bone and bone marrow pro-osteoclastogenic cytokines are up-regulated in osteoporosis fragility fractures. in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2011
Show all 6 Pubmed References
Human Monoclonal DKK1 Primary Antibody for ELISA, WB - ABIN966001
Bond, Kuhn, Binstadt, Quirk, Wu, Tews, Dev, Ericsson: The use of simulation in the development of individual cognitive expertise in emergency medicine. in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2008
Show all 3 Pubmed References
Human Monoclonal DKK1 Primary Antibody for ELISA, WB - ABIN969085
Yamamoto, Sakane, Yamamoto, Michiue, Kikuchi: Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling. in Developmental cell 2008
Show all 2 Pubmed References
Dog (Canine) Polyclonal DKK1 Primary Antibody for IF (p), IHC (p) - ABIN678158
Król, Mucha, Majchrzak, Homa, Bulkowska, Majewska, Gajewska, Pietrzak, Perszko, Romanowska, Paw?owski, Manuali, Hellmen, Motyl: Macrophages mediate a switch between canonical and non-canonical Wnt pathways in canine mammary tumors. in PLoS ONE 2014
Show all 2 Pubmed References
Human Polyclonal DKK1 Primary Antibody for IHC (p), ELISA - ABIN4369827
Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: Functional and structural diversity of the human Dickkopf gene family. in Gene 1999
Show all 2 Pubmed References
Human Polyclonal DKK1 Primary Antibody for IHC (p), WB - ABIN388360
Yan, Wu, Chen, Diao, Lai, Huang, Chen, Yu, Gui, Tang, Cai: Developmental expression and function of DKKL1/Dkkl1 in humans and mice. in Reproductive biology and endocrinology : RB&E 2012
Human Polyclonal DKK1 Primary Antibody for IHC (p), ELISA - ABIN250268
Fedi, Bafico, Nieto Soria, Burgess, Miki, Bottaro, Kraus, Aaronson: Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. in The Journal of biological chemistry 1999
Human Monoclonal DKK1 Primary Antibody for IHC (p), IP - ABIN524877
Brunetti, Faienza, Piacente, Ventura, Oranger, Carbone, Benedetto, Colaianni, Gigante, Mori, Gesualdo, Colucci, Cavallo, Grano: High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. in American journal of physiology. Endocrinology and metabolism 2013
Human DKK1 Primary Antibody for IHC (p) - ABIN643515
de Andrade, de Castro, Vicente, da Rosa, Nader, Pereira, Fröde: Evaluation of circulating levels of inflammatory and bone formation markers in axial spondyloarthritis. in International immunopharmacology 2014
Sclerostin (show SOST Antibodies) But Not Dickkopf-1 has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
High serum levels of sclerostin (show SOST Antibodies) and Dkk-1 are associated with acute ischaemic stroke
regulated by Dkk-1 secreted by Multiple Myeloma cells and is a potential mechanism contributing to the osteoblast dysfunction noted in Multiple Myeloma.
DKK1 c.121G>A (p.(A41T)) variant was identified in the family with Chiari malformation type 1. Screening of DKK1 in a cohort of 65 CMI sporadic patients identified another missense variant, the c.359G>T (p.(R120L)), in two unrelated patients.
LRP6 (show LRP6 Antibodies) ectodomain becomes highly compact upon complexation with the Wnt (show WNT2 Antibodies) antagonist Dkk1, suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling.
Our results suggest that measurement of DKK-1 combined with DKK-1 autoantibodies is a potentially valuable tool for the early detection of ESCC.
TET1 (show TET1 Antibodies) potently inhibited canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 (show SFRP2 Antibodies) and DKK1, which was associated with inhibition of EMT (show ITK Antibodies) and cancer cell metastasis.
This is the first study demonstrating a link between B cell depletion and skin Dkk-1 upregulation in patients with systemic sclerosis
We found significantly increased levels of DKK-1 in patients with acute CO poisoning, compared to healthy controls. High levels of serum DKK-1 in patients were significantly correlated with severe neurological symptoms.
DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.
The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Hedgehog (show SHH Antibodies) signaling
DKK1 inhibits the WNT (show WNT2 Antibodies) signaling pathway and improves pig oocyte maturation.
Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD Antibodies) and subsequent maintenance of dkk1b expression levels.
Kremen1 (show KREMEN1 Antibodies) modulates Wnt (show WNT2 Antibodies) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Neuromast size is controlled by a balance between growth-promoting Wnt (show WNT2 Antibodies) signaling activity in proliferation-competent cells and Wnt (show WNT2 Antibodies)-inhibiting Dkk activity produced by differentiated sensory cells.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Data show that injury-dependent induction of Ascl1a (show ASCL1A Antibodies) suppressed expression of the Wnt (show WNT2 Antibodies) signaling inhibitor, Dkk, and induced expression of the Wnt (show WNT2 Antibodies) ligand, Wnt4a.
Membrane-bound DKK-1 is a novel Foxp3 (show FOXP3 Antibodies) postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (show EGF Antibodies) secretion.
Recombinant Dkk1 suppresses beta-catenin (show CTNNB1 Antibodies) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (show CTNNB1 Antibodies) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.
A negative feedback loop involving WNT6 (show WNT6 Antibodies) and DKK1 attenuates canonical WNT6 (show WNT6 Antibodies)-beta-catenin (show CTNNB1 Antibodies) signaling, thereby allowing teratocarcinoma cells to differentiate.
Collectively, miR (show MLXIP Antibodies)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.
that Dkk1 negatively regulates BMP9 (show GDF2 Antibodies)-induced osteogenic differentiation.
Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (show APOE Antibodies)-/- mice.
Dickkopf1 receptor Kremen1 (show KREMEN1 Antibodies) is a bona fide dependence receptor, triggering cell death unless bound to its ligand.
These results suggest that inhibiting Wnt (show WNT2 Antibodies) signaling in embryonic stem cells using DKK1 may promote mouse ESCs (show NR2E3 Antibodies) to differentiate into endoderm in vitro and in vivo
dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (show SHH Antibodies) to determine the different lineages.
N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart
target Wnts of Dkk activity are maternal Wnt5a (show WNT5A Antibodies) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
dickkopf 1 homolog
, dickkopf related protein-1
, dickkopf-1 like
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf homolog 1
, dickkopf-like 1
, dickkopf-like 1 (soggy)
, dickkopf 1
, dickkopf protein