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Serum OPN (show SPP1 Proteins) and DKK1 levels of hepatocellular carcinoma patients could be considered as novel biomarkers showing prognostic significance after hepatectomy based on long-term survival data
These findings suggested that decreased circulating DKK-1 levels are associated with the development and severity of exudative age-related macular degeneration, and have potential to become a biomarker for exudative age-related macular degeneration.
In patients with rheumatoid arthritis, higher levels of DKK1 were found in patients with lower functional status.This could be explained by more structural damage; DKK1 could be used as a biomarker of joint destruction in RA.
miR (show MLXIP Proteins)-590-3p regulates colon cancer progression via WIF1 (show WIF1 Proteins) and DKK1, which suggests that miR (show MLXIP Proteins)-590-3p may be a promising candidate for therapeutic applications in colon cancer treatment
The Dickkopf-1 (DKK1) is a secreted inhibitor of beta-catenin (show CTNNB1 Proteins)-dependent Wnt (show WNT2 Proteins) signalling and was originally characterized as a tumour suppressor based on the prevailing view that Wnt (show WNT2 Proteins) signalling promotes cancer pathogenesis.
Collectively, our data strongly suggest that stress-related neurohormones, such as GCs (show GCLC Proteins), cause DP cells to secrete DKK1, which in turn inhibits hair growth.
Both DKK1 and CKAP4 (show CKAP4 Proteins) are frequently expressed in pancreatic and lung tumours, and their simultaneous expression is negatively correlated with prognosis.
the inhibitory effects of silencing miR (show MLXIP Proteins)-217 on stem cell properties and Wnt (show WNT2 Proteins) signaling were reversed by the downregulation of DKK1 in miR (show MLXIP Proteins)-217-downregulated cells. Therefore, our results indicate that miR (show MLXIP Proteins)-217 plays a vital role in the CSC-like phenotypes of Hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells and may be used as a potential therapeutic target against HCC (show FAM126A Proteins).
In our cohort of pregnant women, sclerostin (show SOST Proteins) and DKK1 were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus.
Serum DKK-1 levels in axial spondyloarthritis depend on disease duration. As disease duration increases, DKK-1 serum levels decrease.
The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and Hedgehog (show SHH Proteins) signaling
DKK1 inhibits the WNT (show WNT2 Proteins) signaling pathway and improves pig oocyte maturation.
Association analysis showed that different genotypes of DKK1 were associated with loin muscle area.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (show CHRD Proteins) and subsequent maintenance of dkk1b expression levels.
Kremen1 (show KREMEN1 Proteins) modulates Wnt (show WNT2 Proteins) activity by restricting the range of secreted Dkk proteins during collective cell migration in the posterior lateral line primordium
Neuromast size is controlled by a balance between growth-promoting Wnt (show WNT2 Proteins) signaling activity in proliferation-competent cells and Wnt (show WNT2 Proteins)-inhibiting Dkk activity produced by differentiated sensory cells.
Dkk1b is abundantly produced by dense regions of androgen-regulated epidermal tubercles on the surfaces of adult male zebrafish pectoral fins
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk, and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.
Collectively, our data strongly suggest that stress-related neurohormones, such as GCs (show UGCG Proteins), cause DP cells to secrete DKK1, which in turn inhibits hair growth.
Diabetic conditions increase the expression of DKK1.
DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis.
Membrane-bound DKK-1 is a novel Foxp3 (show FOXP3 Proteins) postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
Dkk1 promotes hematopoietic regeneration via direct effects on hematopoietic stem cells, decreasing the levels of mitochondrial reactive oxygen species and suppressing senescence, and via indirect effects on bone marrow endothelial cells, inducing EGF (show EGF Proteins) secretion.
Recombinant Dkk1 suppresses beta-catenin (show CTNNB1 Proteins) target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin (show CTNNB1 Proteins) in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs.
A negative feedback loop involving WNT6 (show WNT6 Proteins) and DKK1 attenuates canonical WNT6 (show WNT6 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling, thereby allowing teratocarcinoma cells to differentiate.
Collectively, miR (show MLXIP Proteins)-9 promotes osteoblast differentiation of mesenchymal stem cells by suppressing DKK1 gene expression.
that Dkk1 negatively regulates BMP9 (show GDF2 Proteins)-induced osteogenic differentiation.
Disturbed oscillatory flow increases DKK1 expression. DKK1 knockdown attenuates OSS-induced monocyte adhesion and endothelial impairment. Genetic silencing of DKK1 limits atherogenesis in ApoE (show APOE Proteins)-/- mice.
dkk1 preferentially induced the expression of POX2, suggesting that dkk1 works as a morphogen (show SHH Proteins) to determine the different lineages.
N1 is a novel signaling domain within the intact protein that is responsible for the potent effects of Dkk1 on the induction and patterning of the body axis and heart
target Wnts of Dkk activity are maternal Wnt5a (show WNT5A Proteins) and Wnt11, and that both Wnts are essential for canonical and non-canonical signaling
This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
dickkopf 1 homolog
, dickkopf related protein-1
, dickkopf-1 like
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf homolog 1
, dickkopf 1
, dickkopf protein