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anti-Human PKC beta Antibodies:
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Human Polyclonal PKC beta Primary Antibody for IHC - ABIN966836
Zhang, Liao, Dufau et al.: Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of ... in Molecular and cellular biology 2006
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Chicken Monoclonal PKC beta Primary Antibody for IF, IP - ABIN967768
Bell, Burns: Lipid activation of protein kinase C. in The Journal of biological chemistry 1991
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Chicken Monoclonal PKC beta Primary Antibody for IF, IP - ABIN967769
Masur, Lang, Niggemann, Zanker, Entschladen: High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. in Molecular biology of the cell 2001
Show all 5 Pubmed References
Human Polyclonal PKC beta Primary Antibody for IF, IHC - ABIN871421
Castoria, Migliaccio, Di Domenico, Lombardi, de Falco, Varricchio, Bilancio, Barone, Auricchio: Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. in Molecular and cellular biology 2004
Show all 5 Pubmed References
Cow (Bovine) Polyclonal PKC beta Primary Antibody for WB - ABIN2786693
Tatematsu, Yoshimoto, Okajima, Tanizawa, Kuroda: Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. in The Journal of biological chemistry 2008
our study indicated that PKC alpha and beta appeared coping with oncogenic Ras or mutated Akt to maintain the balance of the homeostasis in cancer cells. Once these PKC isoforms were suppressed, the redox state in the cancer cells was disrupted, which elicited persistent oncogenic stress and subsequent apoptotic crisis.
PKC beta would sensitize cervical cancer cells to chemotherapy via reducing the chemotherapy induced autophagy in cancer cells.
Loss of PRKCB2 expression is associated with colorectal cancer.
significantly different gene expressions of BECN1 and PRKCB between the control and the Alzheimer's disease (AD) groups and of CDKN2A between the control and the preclinical AD groups, are reported.
a primary functional variant of PRKCB (rs35015313) was identified by genotype imputation using a phased panel of 1,070 Japanese individuals from a prospective, general population cohort study and subsequent in vitro functional analyses. These results may lead to improved understanding of the disease pathways involved in primary biliary cholangitis.
our findings identify PRKCB gene as a novel candidate gene for familial Meniere's Disease (MD )and its expression gradient in supporting cells of the organ of Corti deserves attention, given the role of supporting cells in K(+ )recycling within the endolymph, and its apical turn location may explain the onset of hearing loss at low frequencies in MD
Activation of the Pro-Oxidant PKCbetaII-p66Shc (show SHC1 Antibodies) Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SH (show POLD3 Antibodies)CA (p66) activation invol (show SIGLEC1 Antibodies)ving Ser(139) and a motif surroun (show SIGLEC1 Antibodies)ding Ser(213).
The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (show JUN Antibodies), CEBPB (show CEBPB Antibodies), PRKCB, ENO2 (show ENO2 Antibodies), or CEBPG (show CEBPG Antibodies)) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
Our results provide compelling evidence that glucose-induced PKCalpha (show PKCa Antibodies)/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
These results provide a molecular explanation of how initiation of B cell activation (show BLNK Antibodies) discriminates substrate stiffness through a PKCbeta-mediated FAK (show PTK2 Antibodies) activation dependent manner.
propose that PKCbeta acts to suppress the degradation of FTO (show FTO Antibodies) protein and reveals the associated role of PKCbeta and FTO (show FTO Antibodies) in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 (show POLD3 Antibodies) activation involving Ser (show SIGLEC1 Antibodies)(139) and a motif surrounding Ser (show SIGLEC1 Antibodies)(213).
Translocation of PKC-betaII from the cytoplasm to membranes is required for phagocytosis of apoptotic cells and is inhibited by soluble beta-glucan
repressor of myogenesis; opposes calcineurin function
a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18 (show IL18 Antibodies)/IL-18BP (show IL18BP Antibodies) pathway, leading to increased VCAM-1 (show VCAM1 Antibodies) expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
These results demonstrate the importance of PKCbetaII in chronic lymphocytic leukemia-like disease progression and suggest a role for PKCalpha (show PKCa Antibodies) subversion in creating permissive conditions for leukemogenesis.
PKCbeta2 inhibition protects mice from gut (show GUSB Antibodies) ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.
PKC-alpha (show PKCa Antibodies) and -betaIotaIota are the predominant isoforms in the developing optic pathway, whereas PKC-epsilon (show PRKCE Antibodies) is the major form in the chiasmatic neurons.
The study identified the serine phosphorylation (p-Ser (show SIGLEC1 Antibodies)) sites induced by PKC-Beta activation or AGT (show AGT Antibodies), which inhibits insulin (show INS Antibodies)-induced p-Tyr (show TYR Antibodies) sites on IRS2 (show IRS2 Antibodies) and its signals in endothelial cells.
ET-1 (show EDN1 Antibodies)-mediated myocardial contractile dysfunction during cardioplegia involves activation of protein kinase C beta II.
The PKCalpha (show PKCa Antibodies), PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
Increases in epicardial perivascular adipose tissue leptin (show LEP Antibodies) exacerbate coronary endothelial dysfunction in MetS (show MARS Antibodies) via a PKC-beta-dependent pathway.
first study to show the expression and cellular localization of PKC beta I in the retina of pigs with development, and these results suggest that PKC beta I, in accordance with PKC alpha (show PKCa Antibodies), plays important roles in signal transduction pathways in the pig retina with development
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, protein kinase C beta type
, protein kinase C, beta 1 polypeptide
, protein kinase C beta-II
, protein kinase C, beta 1
, protein kinase C beta I
, protein kinase C beta II
, protein kinase C beta 1
, protein kinase C, beta
, protein kinase C beta 2