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anti-Human PKC beta Antibodies:
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Human Polyclonal PKC beta Primary Antibody for IHC - ABIN966836
Zhang, Liao, Dufau et al.: Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of ... in Molecular and cellular biology 2006
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Polyclonal PKC beta Primary Antibody for ELISA, WB - ABIN539471
Zhang, Wang, Petrin, Bishop, Bond: Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites. in Proceedings of the National Academy of Sciences of the United States of America 1993
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Human Polyclonal PKC beta Primary Antibody for IHC (p), ELISA - ABIN545456
Hug, Ahmed, Robbins, Lazar: A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene. in The Journal of biological chemistry 2004
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Human Polyclonal PKC beta Primary Antibody for WB - ABIN3043550
Wang, Qin, Deng, Yao: Different localization and expression of protein kinase C-beta in kidney cortex of diabetic nephropathy mice and its role in telmisartan treatment. in American journal of translational research 2015
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Human Polyclonal PKC beta Primary Antibody for IHC, WB - ABIN6713413
Bai, Zhang, Hua, Wang, Ling, Ferro, Xu: Metformin inhibits angiotensin II-induced differentiation of cardiac fibroblasts into myofibroblasts. in PLoS ONE 2014
Cow (Bovine) Polyclonal PKC beta Primary Antibody for WB - ABIN2786693
Tatematsu, Yoshimoto, Okajima, Tanizawa, Kuroda: Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. in The Journal of biological chemistry 2008
Human Polyclonal PKC beta Primary Antibody for IHC (p), ELISA - ABIN545457
Zhang, Major, Takanashi, Camp, Nishiya, Peters, Ginsberg, Jian, Randazzo, Schultz, Moon, Ding: Small-molecule synergist of the Wnt/beta-catenin signaling pathway. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Polyclonal PKC beta Primary Antibody for IF, IHC - ABIN871421
Castoria, Migliaccio, Di Domenico, Lombardi, de Falco, Varricchio, Bilancio, Barone, Auricchio: Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. in Molecular and cellular biology 2004
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Human Polyclonal PKC beta Primary Antibody for Func, ICC - ABIN4345827
Dobrikov, Dobrikova, Gromeier: Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding. in Molecular and cellular biology 2018
Cancer-associated hotspot mutations in the pseudosubstrate of PKCbeta that impair autoinhibition result in dephosphorylated and unstable enzymes. Protein-level analysis reveals that PKCalpha is fully phosphorylated at the PHLPP site in over 5,000 patient tumors, with higher PKC levels correlating (1) inversely with PHLPP1 levels and (2) positively with improved survival in pancreatic adenocarcinoma
expression of PRKCB mRNA might be correlated with the pathogenesis of systemic lupus erythematosus
We found that RACK1:PKCbetaII phosphorylates eukaryotic initiation factor 4G1 (eIF4G1) at S1093 and eIF3a at S1364. Our findings reveal a physiological role for ribosomal RACK1 in providing the molecular scaffold for PKCbetaII and its role in coordinating the translational response to PKC-Raf-ERK1/2 activation.
For unraveling mechanisms of RACK1:PKCbetaII-mediated translation stimulation, we used sequentially truncated eIF4G1 in coimmunoprecipitation analyses to delineate a set of autoinhibitory elements in the N-terminal unstructured region (surrounding the eIF4E-binding motif) and the interdomain linker (within the eIF3-binding site) of eIF4G1.
High glucose affected the expression of angiogenic factors in choriocarcinoma cells via the PKCbeta and HIF-1alpha pathways, suggesting their involvement in preeclampsia pathogenesis.
Tumor suppressor activity of protein kinase C-beta.[review]
The results demonstrate a direct relationship between SP1 binding and protein kinase CbetaII (PKCbetaII) transcription, and further suggest that this transcription factor is a contributor to the pathobiology of chronic lymphocytic leukaemia and potentially other malignant cells where PKCbetaII is overexpressed.
An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with SNP rs9922316 in the gene for protein kinase C type beta ( PRKCB).
our study indicated that PKC alpha and beta appeared coping with oncogenic Ras or mutated Akt to maintain the balance of the homeostasis in cancer cells. Once these PKC isoforms were suppressed, the redox state in the cancer cells was disrupted, which elicited persistent oncogenic stress and subsequent apoptotic crisis.
PKC beta would sensitize cervical cancer cells to chemotherapy via reducing the chemotherapy induced autophagy in cancer cells.
Loss of PRKCB2 expression is associated with colorectal cancer.
significantly different gene expressions of BECN1 and PRKCB between the control and the Alzheimer's disease (AD) groups and of CDKN2A between the control and the preclinical AD groups, are reported.
a primary functional variant of PRKCB (rs35015313) was identified by genotype imputation using a phased panel of 1,070 Japanese individuals from a prospective, general population cohort study and subsequent in vitro functional analyses. These results may lead to improved understanding of the disease pathways involved in primary biliary cholangitis.
our findings identify PRKCB gene as a novel candidate gene for familial Meniere's Disease (MD )and its expression gradient in supporting cells of the organ of Corti deserves attention, given the role of supporting cells in K(+ )recycling within the endolymph, and its apical turn location may explain the onset of hearing loss at low frequencies in MD
Activation of the Pro-Oxidant PKCbetaII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Patients With Diabetes With Critical Limb Ischemia
Taken together, these data argue for a complex mechanism of PKC-beta-dependent regulation of SHCA (p66) activation involving Ser(139) and a motif surrounding Ser(213).
The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN, CEBPB, PRKCB, ENO2, or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
Our results provide compelling evidence that glucose-induced PKCalpha/PKCbeta-mediated inhibition of Kv current in vascular smooth muscle causes an enhanced constrictor response. Inhibition of Kv current causes a significant depolarization of vascular myocytes leading to marked vasoconstriction
Data suggest that targeted manipulation of protein kinase C isoforms PKCalpha, PKCbeta, and PKCeta might be beneficial in certain proteinuric kidney diseases with altered transient receptor potential cation channel subfamily C member 6 protein (TRPC6) functions.
Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kdelta or PKCbeta signaling pathways.
phorbol 12-myristate 13-acetate induced PRKCB, improved lipopolysaccharide-tolerance, and attenuated sepsis severity, predominantly in FcGRIIb-/- mice.
These data identify a key mechanistic link between transient PKC activation and long-term Ca(2+) handling defects through PKC-induced actin cytoskeletal rearrangement and resultant T-tubule damage.
our results suggest that the decrease in the activity of cPKCbetaII and cPKCgamma, especially cPKCgamma, may play key roles in the pathogenesis of diabetic encephalopathy.
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
The absence of gut microbiota from birth was shown to be associated with decreased CREB expression, followed by decreases of protein kinase C beta (PRKCB) and AMPA receptors expression, and an increase of phosphorylation CREB (pCREB) expression.
These results provide a molecular explanation of how initiation of B cell activation discriminates substrate stiffness through a PKCbeta-mediated FAK activation dependent manner.
high glucose stimulates PKCbeta signaling, which leads to MR stabilization and its transcriptional activities.
propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases
Cytosolic NELL2 specifically interacts with PKC beta isotypes and inhibits PKC beta1 through direct binding to the N-terminal pseudosubstrate domain of PKC beta1.
Taken together, these data argue for a complex mechanism of PKCbeta-dependent regulation of p66 activation involving Ser(139) and a motif surrounding Ser(213).
Translocation of PKC-betaII from the cytoplasm to membranes is required for phagocytosis of apoptotic cells and is inhibited by soluble beta-glucan
repressor of myogenesis; opposes calcineurin function
a new mechanism by which PKC-beta activation promotes EC dysfunction caused by the de-regulation of the IL-18/IL-18BP pathway, leading to increased VCAM-1 expression, monocyte/macrophage adhesion, and accelerated atherosclerotic plaque formation in diabetes
These results demonstrate the importance of PKCbetaII in chronic lymphocytic leukemia-like disease progression and suggest a role for PKCalpha subversion in creating permissive conditions for leukemogenesis.
has a key role in the differentiation of osteoclasts
PKCbeta2 inhibition protects mice from gut ischemia-reperfusion injury by suppressing the adaptor p66(Shc)-mediated oxidative stress and subsequent apoptosis.
PKC-alpha and -betaIotaIota are the predominant isoforms in the developing optic pathway, whereas PKC-epsilon is the major form in the chiasmatic neurons.
STAT3 bound to previously undescribed negative regulatory elements within the promoter of PRKCB, which encodes PKCbetaII.
These findings indicate that the identity of the calcium-dependent PKCbeta that mediates PTP controls the mechanism and functional consequences of Posttetanic potentiation.
The activation of protein kinase C beta (PRKCB), negatively modulates the mitochondrial energy status and inhibits autophagy.
The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AGT, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells.
ET-1-mediated myocardial contractile dysfunction during cardioplegia involves activation of protein kinase C beta II.
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
Increases in epicardial perivascular adipose tissue leptin exacerbate coronary endothelial dysfunction in MetS via a PKC-beta-dependent pathway.
first study to show the expression and cellular localization of PKC beta I in the retina of pigs with development, and these results suggest that PKC beta I, in accordance with PKC alpha, plays important roles in signal transduction pathways in the pig retina with development
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, protein kinase C beta type
, protein kinase C, beta 1 polypeptide
, protein kinase C beta-II
, protein kinase C, beta 1
, protein kinase C beta I
, protein kinase C beta II
, protein kinase C beta 1
, protein kinase C, beta
, protein kinase C beta 2
, protein kinase C, beta 1, like
, protein kinase C, beta a