PKC beta antibody (AA 642-673)

Catalog No. ABIN3032235

Cited in 1 publication. The Rabbit Polyclonal anti-PKC beta antibody (ABIN3032235) specifically detects PKC beta in WB, ELISA and IHC. The antibody is reactive with Human, Rat, Mouse and Primate samples.

Quick Overview for PKC beta antibody (AA 642-673) (ABIN3032235)

Target: PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

Reactivity: Human, Rat, Mouse, Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKC beta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PKC beta Antibody

Binding Specificity: AA 642-673

Purpose: PKC beta 2 Antibody / PRKCB2

Purification: Purified

Immunogen: A portion of amino acids 642-673 from the human protein was used as the immunogen for this PKC beta 2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the PKC beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PKC beta 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

References for anti-PKC beta antibody (ABIN3032235)

Kuai, Luo, Qu, Ru, Luo, Ding, Xing, Liu, Sun, Li, Li: "Transcriptomic Analysis of the Mechanisms for Alleviating Psoriatic Dermatitis Using Taodan Granules in an Imiquimod-Induced Psoriasis-like Mouse Model." in: Frontiers in pharmacology, Vol. 12, pp. 632414, (2021) (PubMed).

Target Details for PKC beta

Target: PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

Alternative Name: PKC beta 2

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.

UniProt: P05771

Pathways: WNT Signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling