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anti-Human TCF3 Antibodies:
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Human Monoclonal TCF3 Primary Antibody for IP, WB - ABIN967433
Bain, Gruenwald, Murre: E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. in Molecular and cellular biology 1993
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Human Monoclonal TCF3 Primary Antibody for IP, WB - ABIN967393
Lenardo, Pierce, Baltimore: Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. in Science (New York, N.Y.) 1987
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Human Polyclonal TCF3 Primary Antibody for WB - ABIN151858
Nie, Xu, Vladimirova, Sun: Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. in The EMBO journal 2003
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Human Monoclonal TCF3 Primary Antibody for FACS, ELISA - ABIN1724729
Firulli, Hadzic, McDaid, Firulli: The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. in The Journal of biological chemistry 2000
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Human Polyclonal TCF3 Primary Antibody for IHC (p), IHC - ABIN188732
Greenbaum, Lazorchak, Zhuang: Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. in The Journal of biological chemistry 2004
Human Monoclonal TCF3 Primary Antibody for ELISA, WB - ABIN563112
Schmeisser, Grabrucker, Bockmann, Boeckers: Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses. in The Journal of biological chemistry 2009
Based on results, TCF3 is clearly associated with the progression of cervical squamous cell carcinoma. This is the first time that it has been reported that TCF3 can act as a tumor promoter in cervical cancer and thus might be of great significance in the prognosis of CSCC (show CYP11A1 Antibodies).
We conclude that inactivation of TCF3 contributes to oncogenic program of classical Hodgkin lymphoma
This is the first time the protein partners of either E2A-PBX1 (show PBX1 Antibodies) or HOXA9 (show HOXA9 Antibodies) oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 (show HOXA9 Antibodies) might indicate a novel function for HOX (show MSH2 Antibodies) proteins independent of their transcriptional activity.
Poly (ADP-ribose) polymerase (show PARP1 Antibodies) inhibitors selectively induce cytotoxicity in TCF3-HLF (show EPAS1 Antibodies)-positive leukemic cells.
MiR (show MLXIP Antibodies)-138 may be a tumor suppressor and potential prognostic biomarker in cervical cancer. Its downstream target, TCF3, may also regulate cancer development in a reverse manner as miR (show MLXIP Antibodies)-138.
High levels of TCF3 in gliomas promote glioma development through the Akt (show AKT1 Antibodies) and Erk (show EPHB2 Antibodies) pathways.
TWIST1 (show TWIST1 Antibodies)-E12 (show ELSPBP1 Antibodies) protein heterodimeric complexes may thus constitute the main active forms of TWIST1 (show TWIST1 Antibodies) with regard to senescence inhibition over the time course of breast tumorigenesis.
Review of the role of the E2A-PBX1 (show PBX1 Antibodies) gene rearrangement in the prognosis of childhood acute lymphoblastic leukemia and its central nervous system relapse.
Our data suggest that E2A antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages.
E47 is a novel substrate of PAK5 (show PAK6 Antibodies), and PAK5 (show PAK6 Antibodies)-mediated phosphorylation of E47 promotes epithelial-mesenchymal transition. High expression of phospho-E47 was associated with an aggressive phenotype of colon cancer and metastasis.
Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B (show SPIB Antibodies) and the suppressor of cytokine signaling 3 (SOCS3 (show SOCS3 Antibodies)), which both downregulated Foxp3 (show FOXP3 Antibodies) expression. These findings demonstrate that the balance of Id3 (show ID3 Antibodies) and E47 controls the maintenance of Foxp3 (show FOXP3 Antibodies) expression in Treg cells and, thus, contributes to Treg cell plasticity.
this study identifies E2A target genes in embryonic neural stem cells and demonstrates that E47 regulates neuronal differentiation via p57(KIP2 (show CDKN1C Antibodies)).
If Gfi1 (show ZNF163 Antibodies) levels fall below a threshold, Id1 (show ID1 Antibodies) expression increases and renders E2A unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
these data identified E2A and E2-2 (show TCF4 Antibodies) as central regulators of B cell immunity.
down-regulation of Id3 (show ID3 Antibodies) in B cells is essential for releasing E2A and E2-2 (show TCF4 Antibodies), which in a redundant manner are required for antigen-induced B cell differentiation.
Data suggest a novel mechanism of drug resistance in which E2a and PRC2 drive changes in the B-cell epigenome; these alterations attenuate alkylating agent treatment-induced apoptosis.
These findings suggest that miR (show MLXIP Antibodies)-506-3p played an important role in regulating NSC proliferation and differentiation via targeting TCF3 (show TCF7L1 Antibodies), and provide a promising avenue for future in-depth research into the functions of miR (show MLXIP Antibodies)-506-3p and TCF3 (show TCF7L1 Antibodies) in nervous system development.
Conditional expression of E2A-HLF (show HLF Antibodies) induces B-cell precursor death and myeloproliferative-like disease in knock-in mice.
Upregulation of E12/E47 by HBx ultimately and concomitant repression of E-cadherin (show CDH1 Antibodies) expression led to epithelial-mesenchymal transition in human hepatocytes.
Mechanistically, E47 repressed the expression of several astrocyte-specific genes in adult NSPCs.
Data indicte that Tcf-1 (show HNF1A Antibodies) and Lef-1 (show LEF1 Antibodies) exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.
VDR interacting repressor
, class B basic helix-loop-helix protein 21
, helix-loop-helix protein HE47
, immunoglobulin transcription factor 1
, kappa-E2-binding factor
, negative vitamin D response element-binding protein
, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
, transcription factor E2-alpha
, transcription factor ITF-1
, vitamin D receptor-interacting repressor
, transcription factor 3
, immunoglobulin enhancer-binding factor E12/E47
, transcription factor A1
, transcription factor E2a
, pancreas specific transcription factor 1c
, transcription regulator Pan
, transcription factor XE12/XE47
, class A basic helix-loop-helix transcription factor G12
, helix-loop-helix protein E12
, helix-loop-helix protein E47
, transcription factor 7-like 1 (T-cell specific, HMG-box)