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Human TCF4 Protein expressed in Wheat germ - ABIN1322369
Schenkel, Zloza, Li, Narasipura, Al-Harthi: Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2010
rs613872, rs17595731, and CTG repeat expansions in intronic region of TCF4 are associated with increased risk of sporadic late-onset FECD (show COL8a2 Proteins) in the Indian cohort studied
High TCF4 expression is associated with colorectal cancer.
Examination of X-ray structures of the closely related TCF3 (show TCF3 Proteins) and USF1 (show USF1 Proteins) bound to DNA suggests TCF3 (show TCF3 Proteins) can undergo a conformational shift to preferentially bind to 5hmC while the USF1 (show USF1 Proteins) basic region is bulkier and rigid precluding a conformation shift to bind 5hmC. These results greatly expand the regulatory DNA sequence landscape bound by TCF4.
Array-comparative genomic hybridization confirmed a de novo paternal deletion of the 15q11.2q13 region and exome sequencing identified a second mutational event in both girls, which was a novel variant c.145+1G>A affecting a TCF4 canonical splicing site inherited from the mosaic mother
The CTG18.1 repeat expansion may reduce gene expression of TCF4 and ZEB1, suggesting that a mechanism triggering a loss of function may contribute to FECD (show COL8a2 Proteins).
repeat expansion showed stronger association than the most significantly associated SNP, rs613872, in TCF4, with the disease in the Australian cohort
Although validation in additional patients is required, the findings suggest that the dysmorphic features and severe intellectual disability characteristic of PTHS are partially rescued by overexpression of those short TCF4 transcripts encoding a nuclear localization signal, a transcription activation domain, and the basic helix-loop-helix domain.
Altered DNA methylation (show HELLS Proteins) in TCF4 involves in the etiology of Bipolar disorder and Major Depressive disorder .
We found that the genotype "AG" of rs9320010 and "GA" of rs7235757 decreased SCZ risk. In the genetic model analysis, we also observed that the allele "A" of rs9320010 and "G" of rs7235757 were inversely related with the risk of SCZ in the dominant model. Our study indicated that rs9320010, rs7235757, and rs1452787 were prominently associated with SCZ.
Our work suggests that DM1 (show DMPK Proteins) patients are at risk for Fuchs' endothelial corneal dystrophy (FECD (show COL8a2 Proteins)). DMPK (show DMPK Proteins) mutations contribute to the genetic burden of FECD (show COL8a2 Proteins) but are uncommon. We establish a connection between two repeat expansion disorders converging upon RNA-MBNL1 (show MBNL1 Proteins) foci and FECD (show COL8a2 Proteins).
Hdac2 (show HDAC2 Proteins) isoform-selective knockdown was sufficient to rescue memory deficits in Tcf4(+/-) mice.
We report that TCF4 comprises two transcriptional isoforms, both of which are required for optimal plasmacytoid DC development in vitro
these data identified E2A (show TCF3 Proteins) and E2-2 as central regulators of B cell immunity.
down-regulation of Id3 (show ID3 Proteins) in B cells is essential for releasing E2A (show TCF3 Proteins) and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation.
TCF-4 as a co-activator of p65 (show NFkBP65 Proteins) in the potentiation of proinflammatory cytokine production in macrophages and aggravation of high-fat diet induced chronic inflammation and insulin (show INS Proteins) resistance in mice.
Data indicate that upregulation of E2-2 protein markedly attenuated the inhibitor of DNA-binding 1 (ID1 (show ID1 Proteins))-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.
We conclude that E2-2 inhibited EPC (show TCF21 Proteins) proliferation via suppressing their autophagy, and E2-2 regulated EPC (show TCF21 Proteins) autophagy by mediating the expression of ATG7 (show ATG7 Proteins).
demonstrated that Id1 (show ID1 Proteins) and E2-2 are critical regulators of EPCs function in vitro. Id1 (show ID1 Proteins) interacts with E2-2 and relieves the E2-2-mediated repression of FGFR1 (show FGFR1 Proteins) and VEGFR2 (show KDR Proteins) expression to modulate EPCs functions
TCF4 is a regulator of neuronal intrinsic excitability in part by repression of Kcnq1 (show KCNQ1 Proteins) and Scn10a (show SCN10A Proteins).
A disease-promoting role of E2-2 dependent pDCs in the pancreas.
GRG5/AES (show AES Proteins) interacts with TCF4 (show TCF7L2 Proteins) and represses Wnt (show WNT2 Proteins)-mediated transcription both in human cells and zebrafish embryos.
Data indicte that Tcf-1 (show HNF1A Proteins) and Lef-1 (show LEF1 Proteins) exhibit a function in the axis induction assay, which is lacking in Tcf-3 (show TCF3 Proteins) and -4.
Tcf4 (show TCF7L2 Proteins) transcription factor cooperates in patterning the Xenopus brain.
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described.
SL3-3 enhancer factor 2
, class B basic helix-loop-helix protein 19
, immunoglobulin transcription factor 2
, Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)
, class A helix-loop-helix transcription factor ME2
, immunoglobulin transcription factor-2
, R8f DNA-binding protein
, thyroglobulin promoter transcription factor TFE
, transcription factor 7-like 2 (T-cell specific, HMG-box)
, transcriptional factor 4
, helix-loop-helix transcription factor
, LOW QUALITY PROTEIN: transcription factor 4