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Wnt7a has a role in postmenstrual regeneration and proliferation of endometrial glands and luminal epithelium in primates
experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS epithelial cells to promote angiogenesis and regulate the BBB
WNT7a is sufficient to restore post-pubertal endometrial gland formation.
we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3 (show PSA Proteins)) and other kallikrein (show KLK1 Proteins)-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins
Data show that the WIF domain of Wnt Inhibitory Factor 1 (WIF1 (show WIF1 Proteins)) is bound by C-terminal domains of Wnt (show WNT2 Proteins) proteins Wnt5a (show WNT5A Proteins) and Wnt7a at two sites.
Wnt7a is a novel regulator of ventral midbrain neurogenesis and dopaminergic neuron axon growth and guidance.
Truncated Wnt7a lacking the conserved palmitoylation sites retains full biological activity in skeletal muscle.
epithelial Wnt7a and Wnt7b (show WNT7B Proteins) are possible ligands of Fzd-mediated beta-catenin (Ctnnb1 (show CTNNB1 Proteins))-dependent (canonical) Wnt (show WNT2 Proteins) signaling in the adjacent undifferentiated periotic mesenchyme of fibrocytes in the murine inner ear
Binding of Wnt7a to Fzd7 leads to an activation of noncanonical Wnt (show WNT2 Proteins) signaling, resulting in directed myogenic stem cell migration and enhanced engraftment.
Wnt7a triggers melanocyte stem cell differentiation through beta-catenin (show CTNNB1 Proteins) activation, and Kitl (show KITLG Proteins) might induce following migration of melanoblasts to epidermis
Wnt7a exercised critical control over multiple steps of neurogenesis by regulating genes involved in both cell cycle control and neuronal differentiation.
Activation of the WNT (show WNT2 Proteins)/CTNBB1 pathway via WNT7A might play a role in PTC (show F9 Proteins) development.
Results show that Wnt7a expression is significantly upregulated in epithelial cells of ovarian cancer which correlates with STAT4 (show STAT4 Proteins) expression and provide evidence that STAT4 (show STAT4 Proteins) promotes ovarian cancer metastasis via tumor-derived Wnt7a-induced activation of cancer-associated fibroblasts.
WNT7A is a direct target of miR (show MLXIP Proteins)-15b in ovarian cancer cell line.
The findings presented in this fetus are compatible with diagnosis of Al-Awadi-Raas-Rothschild syndrome , expanding the mutational spectrum of limb malformations arising from defects in WNT7A
Wnt7a is involved in the transformation of the retinal pigment epithelium.
Wnt7a overexpression is associated with an unfavorable prognosis and that positive Wnt7a may be an independent prognosis factor influencing OS and DFS (show FST Proteins) prediction in colorectal cancer patients.
identified Iloprost, a prostacyclin analog, which initiates downstream signaling cascades similar to that of Wnt7a, as a novel inducer of cellular senescence, presenting potential future clinical translational strategies
Prognosis was significantly more favorable for patients with high Wnt7A expression.
loss of the Wnt7a gene induced by promoter methylation might be a prognostic factor for non-small cell lung carcinoma
this is the first study reporting reduced WNT7A levels in cervical cancer -derived cells and that ectopic WNT7A restoration negatively affects cell proliferation and migration.
Wnt7a haplotype 1 had the highest haplotype frequencies and was highly significantly associated with body height, body weight, chest width and height at hip cross.
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes.
, wingless-type MMTV integration site family, member 7A
, postaxial hemimelia
, proto-oncogene Wnt7a protein
, wingless-related MMTV integration site 7A
, wingless-type MMTV integration site 7A
, Protein Wnt-7a
, wnt-1 related (wnt-7a), wingless-type MMTV integration site family
, protein Wnt-7a-like