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anti-Rat (Rattus) ZNRF3 Antibodies:
anti-Human ZNRF3 Antibodies:
anti-Mouse (Murine) ZNRF3 Antibodies:
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Missense variants of ZNRF3 are associated with Disorders of Sex Development.
Data suggest that inactivation of RNF43 (show RNF43 Antibodies) and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype.
ZNRF3 inhibited the metastasis and tumorigenesis via suppressing the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway in NPC (show NPC1 Antibodies) cells.
Data indicate that clinical specimens showed a significant inverse correlation between zinc and ring finger 3 (ZNRF3) and beta-catenin (show CTNNB1 Antibodies) mRNA levels.
miR (show MLXIP Antibodies)-93/ZNRF3/Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) regulatory network contributes to the growth of lung carcinoma.
ZnRF3 negatively influences both the Wnt (show WNT2 Antibodies) and Hedgehog (show SHH Antibodies) proliferative pathways, and probably this way it negatively regulates cancer progression.
ZnRF3 negatively influences both the Wnt (show WNT2 Antibodies) and Hedgehog (show SHH Antibodies) proliferative pathways and probably this way it negatively regulates cancer progression
Report shows that miR (show MLXIP Antibodies)-146b participated in migration, invasion and chemoresistance in osteosarcoma via downregulation of ZNRF3.
Data indicate Dishevelled (DVL (show DVL2 Antibodies)) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 (show RNF43 Antibodies) to Wnt (show WNT2 Antibodies) receptors to ensure proper control of pathway activity.
ZNRF3 binds RSPO1 (show RSPO1 Antibodies) and LGR5 (show LGR5 Antibodies)-RSPO1 (show RSPO1 Antibodies) with micromolar affinity via RSPO1 (show RSPO1 Antibodies) furin (show FURIN Antibodies)-like 1 (Fu1) domain.
XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects.
RSPO (show RSPO1 Antibodies)-LGR4 (show LGR4 Antibodies)/5-ZNRF3/RNF43 (show RNF43 Antibodies) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
Crystal structure confirming that Rspo (show RSPO1 Antibodies) proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.
data suggest that R-spondin enhances Wnt (show WNT2 Antibodies) signalling by inhibiting ZNRF3
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway.
, E3 ubiquitin-protein ligase ZNRF3
, RING finger protein 203
, novel C3HC4 type Zinc finger (ring finger)
, zinc/RING finger protein 3