ZNRF3 antibody (AA 56-219)

Catalog No. ABIN7151318

This Rabbit Polyclonal antibody specifically detects ZNRF3 in ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for ZNRF3 antibody (AA 56-219) (ABIN7151318)

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNRF3 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-ZNRF3 Antibody

Binding Specificity: AA 56-219

Purpose: ZNRF3 Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ZNRF3

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Alternative Name: ZNRF3

Background:

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Aliases: ZNRF3 antibody, KIAA1133 antibody, RNF203 antibody, E3 ubiquitin-protein ligase ZNRF3 antibody, EC 2.3.2.27 antibody, RING finger protein 203 antibody, RING-type E3 ubiquitin transferase ZNRF3 antibody, Zinc/RING finger protein 3 antibody

UniProt: Q9ULT6

Pathways: WNT Signaling