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AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1\; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008].. Additionally we are shipping AZI2 Antibodies (17) and many more products for this protein.
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These results define NAK-associated protein 1 (NAP1) as an activator of IkappaB kinase (show CHUK Proteins)-related kinases and suggest that the NAK (show TBK1 Proteins)-NAP1 (show IL8 Proteins) complex may protect cells from TNF-alpha (show TNF Proteins)-induced apoptosis by promoting NF-kappaB (show NFKB1 Proteins) activation.
Both the cytoplasmic and TLR3 (show TLR3 Proteins)-mediated dsRNA recognition pathways converge upon NAP1 (show IL8 Proteins) for the activation of the IRF-3 (show IRF3 Proteins) and IFN-beta (show IFNB1 Proteins) promoter.
the spatiotemporal mobilization of TICAM-1 (show TICAM1 Proteins) in response to dsRNA and the formation of the TICAM-1 (show TICAM1 Proteins) speckles containing RIP1 (show UQCRFS1 Proteins) and NAP1 (show IL8 Proteins) are important for the activation of the TLR3 (show TLR3 Proteins)-TICAM-1 (show TICAM1 Proteins) pathway.
AZI2 expression is critical for the generation of cDCs by GM-CSF (show CSF2 Proteins) and can potentially be used to increase the efficiency of immunization by cDCs.
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1\; MIM 604834) (Fujita et al., 2003
5-azacytidine induced gene 2
, 5-azacytidine-induced protein 2
, NAK-associated protein 1
, NF-kappa-B-activating kinase-associated protein 1