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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. Additionally we are shipping AKAP5 Kits (10) and AKAP5 Proteins (6) and many more products for this protein.
Showing 10 out of 65 products:
Human Monoclonal AKAP5 Primary Antibody for WB - ABIN393451
Willoughby, Masada, Wachten, Pagano, Halls, Everett, Ciruela, Cooper: AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. in The Journal of biological chemistry 2010
Show all 5 references for ABIN393451
Human Monoclonal AKAP5 Primary Antibody for IF, IP - ABIN967900
Carr, Stofko-Hahn, Fraser, Cone, Scott: Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. in The Journal of biological chemistry 1992
Show all 4 references for ABIN967900
Cow (Bovine) Polyclonal AKAP5 Primary Antibody for WB - ABIN2775174
Tavalin: AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. in The Journal of biological chemistry 2008
Cigarette smoke-induced changes in AKAP5 and AKAP12 (show AKAP12 Antibodies) in patients with COPD (show ARCN1 Antibodies) may affect efficacy of pharmacotherapy.
human AKAP79-anchored PKC selectively phosphorylates the Robo3.1 receptor subtype on serine 1330
GPR30 (show GPER Antibodies) interacted with membrane-associated guanylate kinases and protein kinase A-anchoring protein (show AKAP10 Antibodies) (AKAP) 5 in the plasma membrane in a PDZ (show INADL Antibodies)-dependent manner.
a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells.
Patients with bipolar disorder have higher density of AKAP5-expressing neurons in the anterior cingulate cortex compared with controls.
AKAP79, PKC (show PRRT2 Antibodies), PKA and PDE4 (show PDE4A Antibodies) participate in a Gq-linked muscarinic receptor (show CHRM5 Antibodies) and adenylate cyclase 2 (show ADCY2 Antibodies) cAMP signalling complex.
The results of this study suggested that antagonizing the TRPV1 (show TRPV1 Antibodies)-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia.
AKAP5 Pro100Leu effects on emotion processing might be task-dependent with Pro homozygotes showing lower control of emotional interference, but more efficient processing of task-relevant emotional stimuli.
Antagonizing the interaction between AKAP79 and TRPV1 (show TRPV1 Antibodies) inhibits inflammatory hyperalgesia.
the direct anchoring of both PKA and AC to TRPV1 (show TRPV1 Antibodies) by AKAP79/150 facilitates the response to inflammatory mediators and may be critical in the pathogenesis of thermal hyperalgesia.
the C-helix of protein kinase A inhibitory regulatory subunit is identified as a highly dynamic switch which relays cyclic AMP (show TMPRSS5 Antibodies) binding to the helical catalytic-subunit binding regions
This study demonstrated that the AKAP150 oordinates metabotropic glutamate (show GRIN1 Antibodies) receptor sensitization of peripheral sensory neurons.
Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities.
Identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII (show CAMK2G Antibodies) and highlight a significant role for cardiac beta-ARs (show SLURP1 Antibodies) in this phenomenon.
endothelial-dependent dilation of resistance arteries is enabled by MEP (show CTSL1 Antibodies)-localized AKAP150, which ensures the proximity of PKC (show PKC Antibodies) to TRPV4 (show TRPV4 Antibodies) channels and the coupled channel gating necessary for efficient communication from endothelial to smooth muscle cells
Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa (show KCNMA1 Antibodies) channel remodeling, which contributes to vasoconstriction during diabetes mellitus.
Anchoring of protein kinase A and adenylyl cyclase by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA (show GRIA3 Antibodies) receptor activity.
Results show that in the same protein complex in which PKA augments L currents, AKAP79/150 directs calcineurin (show PPP3CA Antibodies) to activate NFAT (show NFATC1 Antibodies) and initiate a longer-term feedback loop that upregulates M-channel expression, countering increased neuronal excitability.
AKAP150 null mice secrete less insulin (show INS Antibodies) yet have better glucose handling due to increased insulin (show INS Antibodies) sensitivity in target tissues. Tethering of phosphatases to a seven-residue sequence of Akap5 is the main molecular event for this.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.
A kinase (PRKA) anchor protein 5
, A-kinase anchor protein 5
, A-kinase anchor protein 5-like
, a-kinase anchor protein 5-like
, A-kinase anchor protein 79 kDa
, A-kinase anchor protein, 79kDa
, A-kinase anchoring protein 75/79
, AKAP 79
, cAMP-dependent protein kinase regulatory subunit II high affinity binding protein
, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
, A-kinase anchor protein 75 kDa
, AKAP 75
, anchor protein regulatory subunit (AKAP75)
, A-kinase anchor protein 150 kDa
, AKAP 150
, RII-B-binding protein