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ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 Proteins (Adamts2)

Adamts2 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping Adamts2 Antibodies (34) and Adamts2 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Adamts2 216725 Q8C9W3
Adamts2 9509 O95450
Rat Adamts2 Adamts2 287899  
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Top Adamts2 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$841.86
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details

Adamts2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) interaction partners

  1. Data show that the high titer and specific rabbit anti-ADAMTS2 antibody has been prepared successfully.

  2. There is no significant genotype effect of ADAMTS2 on age, height, weight, BMI or sex on risk of Achilles tendon pathology.

  3. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis.

  4. The extent of liver fibrosis is reduced in ADAMTS2-deficient mice in comparison with their wild type littermates.

  5. Data show thatincreased mRNA of Lamb3 (show LAMB3 Proteins) and Adamts2 and enhanced activities of metalloproteinases MMP1 (show MMP1 Proteins), 2 and 7 in transgenic mice expressing the HLA-DQ8.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) interaction partners

  1. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review]

  2. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression.

  3. ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD

  4. Pathway inhibition studies revealed that ADAMTS-2 (show ADAMTS4 Proteins) upregulation by IL-6 (show IL6 Proteins) was mediated by JNK (show MAPK8 Proteins) pathway.

  5. ADAMTS-2 (show ADAMTS4 Proteins), -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI (show CFD Proteins) compared those associated with stable angina.

  6. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis.

  7. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein.

  8. when conditioned media of TSP2 (show THBS2 Proteins)-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 (show THBS2 Proteins) is a potential inhibitor of angiogenesis

  9. Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 2 (Adamts2) interaction partners

  1. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V

Adamts2 Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Adamts2

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 (Adamts2)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 2 (ADAMTS2)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 2 (Adamts2)
  • ADAM-TS2 protein
  • ADAMTS-2 protein
  • ADAMTS-3 protein
  • hPCPNI protein
  • mKIAA4060 protein
  • NPI protein
  • PCI-NP protein
  • PC I-NP protein
  • PCINP protein
  • PCPNI protein
  • PNPI protein
  • RGD1565950 protein

Protein level used designations for Adamts2

A disintegrin and metalloproteinase with thrombospondin motifs 2 , ADAM-TS 2 , PC I-NP , a disintegrin and metalloproteinase with thrombospondin repeats , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 , procollagen I/II amino propeptide-processing enzyme , procollagen N-endopeptidase , procollagen N-proteinase , procollagen I N-proteinase , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 , ADAM-TS2 , ADAMTS-2 , pNPI

GENE ID SPECIES
216725 Mus musculus
9509 Homo sapiens
287899 Rattus norvegicus
416291 Gallus gallus
481453 Canis lupus familiaris
282401 Bos taurus
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