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May play a role in lysosomes motility. Additionally we are shipping ADP-Ribosylation Factor-Like 8B Antibodies (32) and ADP-Ribosylation Factor-Like 8B Kits (17) and many more products for this protein.
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Arl8b regulates the association of the human HOPS (show ALPL Proteins) complex with lysosomal membranes.
a small GTP-binding protein (show ARF3 Proteins), ADP-ribosylation factor-like 8b (Arl8b), is identified as a critical factor required for NK cell-mediated cytotoxicity.
The authors find that Arl8B is required for kinesin-1 recruitment to Salmonella-containing vacuoles, migration of the vacuoles to the cell periphery 24 h after infection and for cell-to-cell transfer of bacteria to neighbouring cells.
Results suggest that the novel GTPases Gie1 and Gie2 (show ARL8A Proteins) associate with microtubules, and might be involved in chromosome segregation.
Arl8b is involved in trafficking processes for lysosomes.
Data show that with MAK3 (show NAA30 Proteins) knockdown, p53 (show TP53 Proteins) is stabilized and phosphorylated and there is a significant transcriptional activation of proapoptotic genes downstream of p53 (show TP53 Proteins), and that localization of Arl8b is altered, suggesting that Arl8b is a Mak3 (show NAA30 Proteins) substrate.
MHC class II presentation is controlled by the lysosomal Arl8b.
Arl8B is required for LPS (show TLR4 Proteins)-stimulated lysosome tubulation in macrophages.
Arl8B plays an important role of Arl8B in neurite formation.
May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).
ADP-ribosylation factor-like 10C
, ADP-ribosylation factor-like protein 10C
, ADP-ribosylation factor-like protein 8B
, novel small G protein indispensable for equal chromosome segregation 1
, small G protein indispensable for equal chromosome segregation 1