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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Additionally we are shipping ATG4B Proteins (13) and many more products for this protein.
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Human Polyclonal ATG4B Primary Antibody for IF, IHC (p) - ABIN1882065
Pontén, Westermark: Properties of human malignant glioma cells in vitro. in Medical biology 1978
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Human Polyclonal ATG4B Primary Antibody for IHC (p), WB - ABIN388494
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG4B Primary Antibody for WB - ABIN1881082
Kabeya, Mizushima, Yamamoto, Oshitani-Okamoto, Ohsumi, Yoshimori: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. in Journal of cell science 2004
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These results support the conclusion that CML24 affects autophagy progression through interactions with ATG4.
AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. [ATG4b]
Reporter assay showed that HSF1 (show HSF1 Antibodies) increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 (show HSF1 Antibodies) bound to the site (-1429 to -1417) in ATG4B gene promoter region.
The structure and regulatory machinery of Atg4b [review]
MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia.
The results have interesting implications that SLC27A4 (show SLC27A4 Antibodies)/ATG4B complex might be conducive to the occurrence of autophagy in human cancer cells, which is meaningful investigations toward the aim of developing autophagy-targeting drugs and have significant values in clinical application.
Results demonstrated that upregulation of miR (show MLXIP Antibodies)-34a by transfection or demethylation resulted in the enhanced apoptosis and drug sensitivity in prostate cancer cells. ATG4B, directly regulated by miR (show MLXIP Antibodies)-34a through AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies), was involved in this process.
Purified ATG4B protein interact with LC3B (show MAP1LC3B Antibodies) in vitro.
ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells.
This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-naive chronic myeloid leukemia (show BCL11A Antibodies) stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells.
The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts.
Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A (show ATG4A Antibodies) for ATG8 (show GABARAPL2 Antibodies) substrates
miR (show MLXIP Antibodies)-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs.
the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis
REDD1 (show DDIT4 Antibodies)/TXNIP (show TXNIP Antibodies) complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy.
these findings demonstrate a role for Ser (show SIGLEC1 Antibodies)-383 and Ser (show SIGLEC1 Antibodies)-392 phosphorylation of ATG4B in control of autophagy.
mTOR (show FRAP1 Antibodies) inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux.
An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA (show CEBPB Antibodies) and is shown to play an important role in 3T3-L1 adipocyte differentiation.
the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 (show MAP1LC3A Antibodies) processing and autophagy.
The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.
Genetic inactivation of mouse Atg4b resulted in amorphous globular bodies in the neuropil of the deep cerebellar nuclei and adjacent vestibular nuclei and a mild but measurable impairment of motor performance on the Rotarod.
The Apg4B/autophagin-1 protease thus serves as a processing/deconjugating enzyme for these four highly divergent mammalian Apg8 homologues, GATE-16 (show GABARAPL2 Antibodies), MAP1 (show MOAP1 Antibodies)-LC3 (show MAP1LC3A Antibodies), GABARAP (show GABARAP Antibodies), and Apg8L (show GABARAPL1 Antibodies).
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ATG4 autophagy related 4 homolog B
, cysteine protease ATG4B
, autophagy 4b variant 1Cysteine protease ATG4B
, autophagy 4b variant 3
, cysteine protease ATG4b
, APG4 autophagy 4 homolog B
, autophagy-related protein 4 homolog B
, autophagy-related cysteine endopeptidase 2B
, AUT-like 1 cysteine endopeptidase
, autophagy-related cysteine endopeptidase 1
, APG4 (ATG4) autophagy-related homolog B
, AUT-like 1, cysteine endopeptidase
, autophagin 1
, autophagy-related 4B
, cysteine protease involved in autophagy APG4-B
, autophagy related 4 homolog B
, autophagy related 4-like protein B