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The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC4 Kits (5) and and many more products for this protein.
Showing 10 out of 133 products:
Human Polyclonal ABCC4 Primary Antibody for ICC, IF - ABIN250309
Cheng, Ren, Jackson: Multidrug resistance protein 4 mediates cAMP efflux from rat preglomerular vascular smooth muscle cells. in Clinical and experimental pharmacology & physiology 2010
Show all 7 references for ABIN250309
Human Polyclonal ABCC4 Primary Antibody for IHC, ELISA - ABIN185302
Schuetz, Connelly, Sun, Paibir, Flynn, Srinivas, Kumar, Fridland: MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. in Nature medicine 1999
Show all 6 references for ABIN185302
Human Monoclonal ABCC4 Primary Antibody for WB - ABIN394823
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Show all 5 references for ABIN394823
Human Polyclonal ABCC4 Primary Antibody for EIA, WB - ABIN359599
Lee, Belinsky, Bell, Testa, Kruh: Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. in Cancer research 1998
Show all 4 references for ABIN359599
Human Polyclonal ABCC4 Primary Antibody for EIA, IF - ABIN374484
Weerachayaphorn, Mennone, Soroka, Harry, Hagey, Kensler, Boyer: Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. in American journal of physiology. Gastrointestinal and liver physiology 2012
Show all 3 references for ABIN374484
Human Polyclonal ABCC4 Primary Antibody for WB - ABIN391639
Adachi, Sampath, Lan, Sun, Hargrove, Flatley, Tatum, Edwards, Wezeman, Matherly, Drake, Schuetz: Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. in The Journal of biological chemistry 2002
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Human Monoclonal ABCC4 Primary Antibody for FACS, IHC - ABIN1724860
Bebes, Kis, Nagy, Kurunczi, Polyánka, Bata-Csörgo, Kemény, Dobozy, Széll: The expressions of ABCC4 and ABCG2 xenobiotic transporters in human keratinocytes are proliferation-related. in Archives of dermatological research 2012
MRP4 is a functional prostaglandin carrier under the regulation of oxytocin in the bovine endometrium.
Data indicate that R-flurbiprofen inhibits multidrug resistance-associated protein 4 (MRP4, ABCC4)-mediated prostaglandins (PG) transport.
Analysis of gene-gene interactions with CYP2B6 (show CYP2B6 Antibodies) was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3 (show DRD3 Antibodies).
The tagSNP ABCC4 rs17268122 appears to be a prognostic factor in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) and surgery, independently of response to nCRT
ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.
Results demonstrated the capacity of MRP4 to confer resistance to arsenite (AsIII), as evidenced by cell survival assays when treated with AsIII in the presence or absence of its two differential inhibitors.
Osteoarthritis patient platelets presented a higher expression of MRP4.
Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.
the specific COX-2 inhibitor meloxicam can increase the intracellular accumulation of doxorubicin and enhance doxorubicin-induced cytotoxicity in A549 cancer cells by reducing the expression of MRP1 and MRP4.
MRP4 overexpression is important to reduce aspirin-selective cell death
Approximately 20% of HIV-infected patients receiving tenofovir showed beta2-microglobulinuria. The C allele at position 4976 of the ABCC4 gene was associated with beta2-microglobulinuria in this population.
The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.
A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.
Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis
Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway
role of MRP4 in thrombus formation
NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
multidrug resistance-associated protein 4
, ATP-binding cassette, sub-family C (CFTR/MRP), member 4
, ATP-binding cassette protein C4-like
, multidrug resistance-associated protein 4-like
, ATP-binding cassette sub-family C member 4
, MRP/cMOAT-related ABC transporter
, bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
, canalicular multispecific organic anion transporter (ABC superfamily)
, multi-specific organic anion transporter B
, multispecific organic anion transporter B
, ATP-binding cassette protein C4