ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) ELISA Kits

The protein encoded by ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC4 Antibodies (133) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ABCC4 10257 O15439
Anti-Mouse ABCC4 ABCC4 239273  
Anti-Rat ABCC4 ABCC4 170924  
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Top ABCC4 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.938 ng/mL 1.56-100 ng/mL 96 Tests Log in to see 13 to 16 Days
$475.20
Details

More ELISA Kits for ABCC4 Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. MRP4 is a functional prostaglandin carrier under the regulation of oxytocin in the bovine endometrium.

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. ABCC4 variant (rs4148500) was significantly associated with hyperuricemia and gout. The gout risk allele was associated with fractional excretion of uric acid in male individuals.

  2. ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia

  3. Data suggest that common SNPs in MRP4/ABCC4 (evaluated here via site-directed mutagenesis in recombinant proteins expressed in kidney cell lines) are responsible for variations in transport of methylated arsenic metabolites (major urinary arsenic metabolites in humans), prostaglandin E2, and estradiol-17 beta-glucuronide.

  4. Data indicate that R-flurbiprofen inhibits multidrug resistance-associated protein 4 (MRP4, ABCC4)-mediated prostaglandins (PG) transport.

  5. Analysis of gene-gene interactions with CYP2B6 (show CYP2B6 ELISA Kits) was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3 (show DRD3 ELISA Kits).

  6. The tagSNP ABCC4 rs17268122 appears to be a prognostic factor in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) and surgery, independently of response to nCRT

  7. ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.

  8. Results demonstrated the capacity of MRP4 to confer resistance to arsenite (AsIII), as evidenced by cell survival assays when treated with AsIII in the presence or absence of its two differential inhibitors.

  9. Osteoarthritis patient platelets presented a higher expression of MRP4.

  10. Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4) interaction partners

  1. The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.

  2. ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.

  3. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  4. These findings have important clinical implications because they directly highlight an important relationship between ABCC4 transporter function and phosphodiesterases in accounting for the cAMP-directed activity of antithrombotic agents.

  5. A novel cAMP-dependent mechanism for MRP4-mediated regulation of fibroblast migration and indicated that PKA and actin play important roles as downstream effectors.

  6. Loss of MRP4 is associated with impaired platelet activation and cAMP homeostasis

  7. Upregulation of COX-2 in lung cancer promotes overexpression of MRP4 via PGE2-dependent pathway

  8. role of MRP4 in thrombus formation

  9. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  10. Abcc4 in the stomach facilitates the oral absorption of dasatinib, and it possibly plays a similar role for other orally administered substrates, such as acetylsalicylic acid.

ABCC4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.

Gene names and symbols associated with ABCC4

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (abcc4) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (Abcc4) antibody
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 4 (Abcc4) antibody
  • D630049P08Rik antibody
  • EST170205 antibody
  • MOAT-B antibody
  • MOATB antibody
  • Mrp4 antibody

Protein level used designations for ABCC4

multidrug resistance-associated protein 4 , ATP-binding cassette, sub-family C (CFTR/MRP), member 4 , ATP-binding cassette protein C4-like , multidrug resistance-associated protein 4-like , ATP-binding cassette sub-family C member 4 , MRP/cMOAT-related ABC transporter , bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4) , canalicular multispecific organic anion transporter (ABC superfamily) , multi-specific organic anion transporter B , multispecific organic anion transporter B , ABC-tranporter , ATP-binding cassette protein C4

GENE ID SPECIES
485523 Canis lupus familiaris
515333 Bos taurus
616707 Bos taurus
695407 Macaca mulatta
100027089 Monodelphis domestica
100050431 Equus caballus
100081616 Ornithorhynchus anatinus
100391624 Callithrix jacchus
100466405 Ailuropoda melanoleuca
100491006 Xenopus (Silurana) tropicalis
10257 Homo sapiens
239273 Mus musculus
170924 Rattus norvegicus
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