ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) ELISA Kits

The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC6 Antibodies (26) and ABCC6 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ABCC6 368 O95255
ABCC6 27421 Q9R1S7
ABCC6 81642 O88269
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Top ABCC6 ELISA Kits at antibodies-online.com

Showing 3 out of 9 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.124 ng/mL 0.31-20 ng/mL 96 Tests Log in to see 13 to 16 Days
$606.32
Details
Human 46.9 pg/mL 78-5000 pg/mL   96 Tests Log in to see 13 to 16 Days
$475.20
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for ABCC6 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. ABCC6 knockdown HepG2 cells show: 1) intracellular reductive stress; 2) cell cycle arrest in G1 phase; 3) upregulation of p21Cip p53 (show TP53 ELISA Kits) independent; and 4) downregulation of lamin A/C (show LMNA ELISA Kits). the absence of ABCC6 profoundly changes the HepG2 phenotype, suggesting that Pseudoxanthoma elasticum syndrome is a complex metabolic disease that is not exclusively related to the absence of pyrophosphate in the bloodstream.

  2. ABCC6 deficiency can be rescued by 4-phenylbutyrate therapy in a mouse model expressing human variants

  3. Biochemical and cell biological analyses demonstrate these mutations influence multiple steps in the biosynthetic pathway, minimally altering local domain structure but adversely impacting ABCC6 assembly and trafficking. The differential impacts on local and global protein structure are consistent with hierarchical folding and assembly of ABCC6.

  4. The results suggest that a transmembrane domain is not required for transport function and that a cytosolic loop maintains ABCC6 in a targeting-competent state for the basolateral membrane and might be involved in regulating the nucleotide binding domains.

  5. The results of this study showed that mtDNA(atp6 (show MT-ATP6 ELISA Kits)) variants were actively involved in schizophrenia in some families with maternal inheritance of this

  6. Pseudoxanthoma elasticum is due to mutation of the ABCC6 gene on chromosome 16.

  7. Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6

  8. A direct relationship between reduced ABCC6 levels and the expression of pro-mineralization genes in hepatocytes.

  9. Minimal rescue of the morpholino-induced phenotype was achieved with eight of the nine mutant human ABCC6 mRNAs tested, implying pathogenicity. This study demonstrates that the Chinese PXE population harbors unique ABCC6 mutations.

  10. Virtual screening expands this possibility to explore more compounds that can interact with ABCC6, and may aid in understanding the mechanisms leading to pseudoxanthoma elasticum

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) interaction partners

  1. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene.

  2. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  3. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression.

  4. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

  5. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum.

  6. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1 (show ENPP1 ELISA Kits)(asj (show ARSJ ELISA Kits)) mice.

  7. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum.

  8. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy.

  9. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation.

  10. A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum.

ABCC6 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene names and symbols associated with ABCC6

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (ABCC6) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6) antibody
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Abcc6) antibody
  • ABC34 antibody
  • Abcc1b antibody
  • ARA antibody
  • DCC antibody
  • dyscalc antibody
  • Dyscalc1 antibody
  • EST349056 antibody
  • GACI2 antibody
  • MLP1 antibody
  • MOAT-E antibody
  • MOATE antibody
  • Mrp6 antibody
  • PXE antibody
  • PXE1 antibody
  • URG7 antibody

Protein level used designations for ABCC6

ATP-binding cassette sub-family C member 6 , anthracycline resistance-associated protein , multi-specific organic anion transporter E , multidrug resistance-associated protein 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein-6 , ATP-binding cassette, sub-family C (CFTR/MRP), member 6 , MLP-1 , MRP-like protein 1 , liver multidrug resistance-associated protein 6

GENE ID SPECIES
368 Homo sapiens
27421 Mus musculus
81642 Rattus norvegicus
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