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ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 Proteins (ATP2A2)

ATP2A2 encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. Additionally we are shipping ATP2A2 Antibodies (55) and ATP2A2 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATP2A2 488 P16615
Rat ATP2A2 ATP2A2 29693 P11507
ATP2A2 11938 O55143
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Top ATP2A2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details

ATP2A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

Top referenced ATP2A2 Proteins

  1. Human ATP2A2 Protein expressed in Wheat germ - ABIN1775707 : Ahmad, Shen, Vandeput, Szabo-Fresnais, Krall, Degerman, Goetz, Klussmann, Movsesian, Manganiello: Regulation of Sarcoplasmic Reticulum Ca2+ ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium: PHOSPHORYLATION-DEPENDENT INTERACTION OF PDE3A1 WITH SERCA2. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Interaction Partners

Xenopus laevis ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Atp2a2/serca2 is found in a larger subset of cells, but is not ubiquitous as reported in adults.

Horse (Equine) ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. the genomic organization and the equine ATP2A2 coding sequence and an association analysis for chronic pastern dermatitis using a sample of South German draft horses

Human ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. CAPN3 (show CAPN3 Proteins) deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  2. High SERCA2 expression is associated with colorectal cancer.

  3. Quantification of SERCA2 mRNA or protein expression levels revealed no differences in airway smooth muscle cells obtained from subjects with asthma compared to non-asthmatic controls.

  4. Inhibition of SERCA2 activity by curcumin disrupts the Ca(2 (show CA2 Proteins)+) homeostasis and thereby promotes apoptosis in ovarian cancer cells.

  5. The association between Darier disease and bipolar disorder is manifest also in the population, and data suggest that genetic variability within the ATP2A2 gene that causes Darier disease also confers susceptibility for bipolar disorder.

  6. ATP2A2 mutation was found in patients diagnosed with Darier disease.

  7. Two novel missense mutations, p.R603I and p.G749V, in the ATP2A2 gene in two families containing individuals diagnosed with Darier disease.

  8. study identified two heterozygous mutations in exon 12 of the ATP2A2 gene in two different Darier disease families

  9. Case Report: ATP2A2 missense mutation at one of the calcium-binding residues causing Darier's disease.

  10. We report here two Chinese Han patients with sporadic Darier disease; mutation analysis of ATP2A2 supported the genetic diagnosis.

Pig (Porcine) ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Data suggest that the beneficial effects of SERCA2a gene transfer may involve the attenuation of ER stress-associated myocardial apoptosis.

  2. Oxidative/nitrosative stress associated with lung resection influences SERCA2a activity independent of any influence on protein expression or phospholamban (show PLN Proteins) phosphorylation.

  3. overexpression of SERCA2a by in vivo rAAV1-mediated intracoronary gene transfer preserved systolic function, potentially prevented diastolic dysfunction, and improved ventricular remodeling.

Rabbit ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. Data show that rabbit cold tolerance is probably related to increased muscle oxidative metabolism and heat production by SERCA1 (show ATP2A1 Proteins) and that these changes are not completely dependent on normal thyroid function.

  2. These results indicate a mechanism relating SERCA1 (show ATP2A1 Proteins) vicinal-cysteines oxidation to muscle fatigue.

Mouse (Murine) ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. CAPN3 (show CAPN3 Proteins) deficiency leads to degradation of SERCA (show ATP2A3 Proteins) proteins and Ca2 (show CA2 Proteins)+ dysregulation in the skeletal muscle.

  2. Sustained activation of Toll-like receptor 9 (show TLR9 Proteins) causes cardiac and systemic inflammation, and deterioration of SERCA2a depletion-mediated diastolic heart failure.

  3. The LRP1 (show LRP1 Proteins)/Pyk2 (show PTK2B Proteins) axis represses SERCA2 mRNA expression via HIF-1a (show HIF1A Proteins).

  4. This first-in-class small-molecule activator targeting SERCA2a SUMOylation may serve as a potential therapeutic strategy for treatment of heart failure

  5. privileged signal communication between the beta1-adrenergic receptor and SERCA2a impaired in cardiac hypertrophy

  6. These data reveal myofibrillar Ca(2 (show CA2 Proteins)+)-sensitivity to be an important determinant of the cardiac effects of SERCA2 haploinsufficiency and raise the possibility that Darier disease patients are more susceptible to heart failure under certain conditions.

  7. SEPN1 enhances SERCA2 activity by reducing luminal cysteines that are hyperoxidized by ERO1-generated peroxides.

  8. SERCA 2 and ERO1 mediate endothelial cell and macrophage angiogenic response to ischemia/hypoxia.

  9. AMPK (show PRKAA1 Proteins) directly relaxes vascular smooth muscle cell by a decrease of [Ca(2 (show CA2 Proteins)+)]i. This is achieved by calcium sequestration via SERCA (show ATP2A3 Proteins) activation, as well as activation of BKCa (show KCNMA1 Proteins) channels.

  10. The results of this study indicate that post-translational modifications of SERCA2a caused by the toxic environment of the hypertrophied and failing myocardium can be prevented by SUMO-1 (show SUMO1 Proteins).

Guinea Pig ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) interaction partners

  1. SERCA2a gene transfer in the failing heart not only improves contractile function but also directly restores electric stability through amelioration of key arrhythmogenic substrate.

ATP2A2 Protein Profile

Protein Summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with ATP2A2

  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (atp2a2)
  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2)
  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2)
  • ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a (atp2a2a)
  • 9530097L16Rik protein
  • ATP2 protein
  • atp2a2 protein
  • ATP2B protein
  • ca-p60a protein
  • D5Wsu150e protein
  • DAR protein
  • DD protein
  • mKIAA4195 protein
  • Serca2 protein
  • SERCA2A protein
  • SERCA2B protein
  • SercaII protein
  • zgc:55380 protein

Protein level used designations for ATP2A2

Calcium ATPase at 60A , ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 , Atp2a2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 2 , sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like , ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2 , SR Ca(2+)-ATPase 2 , calcium pump 2 , calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform , cardiac Ca2+ ATPase , endoplasmic reticulum class 1/2 Ca(2+) ATPase , SERCA2 , calcium ATPase , sarcoplasmic reticulum Ca2+-transport ATPase isoform , Ca(2+)-transport ATPase class 3 , sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2 , ATPase, Ca++ transporting, slow twitch 2 , sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2 , sarco/endoplasmic reticulum Ca2+-ATPase 2 , sarcoplasmic reticulum slow-twitch Ca2 ATPase , serca2

GENE ID SPECIES
380096 Xenopus laevis
452231 Pan troglodytes
540568 Bos taurus
791242 Equus caballus
100398261 Callithrix jacchus
100597073 Nomascus leucogenys
488 Homo sapiens
403878 Canis lupus familiaris
396875 Sus scrofa
100038308 Oryctolagus cuniculus
29693 Rattus norvegicus
11938 Mus musculus
100174978 Cavia porcellus
493691 Felis catus
396446 Gallus gallus
393940 Danio rerio
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