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A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. Additionally we are shipping ATAD2 Antibodies (47) and ATAD2 Kits (4) and many more products for this protein.
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Suppression of ATAD2 impaired the growth of HepG2 and Hep3B subcutaneous xenografts, by enhancing apoptosis and p-p53 (show TP53 Proteins) and p-p38 (show CRK Proteins) levels.
Data indicate that gene expression alterations in endometrial carcinoma samples with high ATPase family, AAA (show APP Proteins) domain containing 2 protein (ATAD2) expression showed upregulation of several cancer-related genes including B-MYB (show MYBL2 Proteins) gene.
Results showed that ATPase family AAA domain-containing 2 overexpression was associated with progression and prognosis of colorectal cancer.
Cervical cancer tissues may have highly expressed ATAD2. Oncogene (show RAB1A Proteins) ATAD2 may play an important role in cervical cancer proliferation, invasion and migration.
We identified ANCCA protein expression as a novel independent poor prognostic indicator in endometrial carcinoma
Study reveals ANCCA as a key mediator of kinesin family deregulation in breast cancer and the crucial role of multiple kinesins in growth and survival of the tumor cells.
Results found that ATAD2 is highly expressed in hepatocellular carcinoma tissues and could affect the expression of hedghog pathway.
High expression of ATAD2 is associated with ovarian carcinomas
miR (show MLXIP Proteins)-372 suppressed the expression of ATAD2, which was highly expressed in HCC (show FAM126A Proteins) and exerted a proto-oncogene (show RAB1A Proteins) effect in hepatic carcinogenesis.
High ANCCA protein expression is associated with lymphatic metastasis in lung adenocarcinoma.
EZH2 (show EZH2 Proteins) and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development.
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.
ATPase family AAA domain-containing protein 2
, AAA nuclear coregulator cancer-associated protein