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anti-Abhydrolase Domain Containing 12 (ABHD12) Antibodies

ABHD12 encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. Additionally we are shipping ABHD12 Proteins (8) and ABHD12 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABHD12 76192 Q99LR1
ABHD12 499913 Q6AYT7
ABHD12 26090 Q8N2K0
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Top anti-ABHD12 Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of ABHD12 Antibody (N-term) (ABIN652851) in mous... Formalin-fixed and paraffin-embedded human testis tissue reacted with ... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using ABHD12 Antibo... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Mouse Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ABHD12 Antibody Titration: 0.2-1 ug/mlPositive Contr... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB EB08783 (0.3µg/ ml) staining of Mouse Brain lysate (35µg/ protein in R... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$595.83
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB ABHD12 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details

ABHD12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
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Rat (Rattus) , , ,
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Human , , , ,
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Top referenced anti-ABHD12 Antibodies

  1. Human Polyclonal ABHD12 Primary Antibody for FACS, IHC (p) - ABIN652851 : Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: The full-ORF clone resource of the German cDNA Consortium. in BMC genomics 2008 (PubMed)

  2. Mouse (Murine) Polyclonal ABHD12 Primary Antibody for EIA, WB - ABIN375165 : Blankman, Simon, Cravatt: A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. in Chemistry & biology 2007 (PubMed)

  3. Human Polyclonal ABHD12 Primary Antibody for ELISA, WB - ABIN1534580 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)

More Antibodies against ABHD12 Interaction Partners

Mouse (Murine) Abhydrolase Domain Containing 12 (ABHD12) interaction partners

  1. In mouse macrophages, disruption of ABHD12 and ABHD16A (show ABHD16A Antibodies) respectively increases and decreases both lysophosphatidylserines and lipopolysaccharide-induced cytokine production.

  2. FAAH (show FAAH Antibodies) but not monoacyl glycerol lipase (show LIPG Antibodies) exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage.

  3. provide a molecular model for PHARC, where disruption of ABHD12 causes deregulated LPS (show TLR4 Antibodies) metabolism and the accumulation of proinflammatory lipids that promote microglial and neurobehavioral abnormalities

  4. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia (show USP14 Antibodies), retinitis pigmentosa, and cataract disease.

  5. Data reveal that 85% of brain 2 (show POU3F2 Antibodies)-arachidonoylglycerol hydrolase (show ABHD6 Antibodies) activity can be ascribed to monoacylglycerol lipase(MAGL (show MGLL Antibodies)), and the remaining 15% is catalyzed by ABHD6 (show ABHD6 Antibodies) and ABHD12.

Human Abhydrolase Domain Containing 12 (ABHD12) interaction partners

  1. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems.

  2. Null mutations in the ABHD12 gene lead to PHARC syndrome, a neurodegenerative disease including polyneuropathy, hearing loss, cerebellar ataxia (show USP14 Antibodies), RP, and early-onset cataract. Our study allowed us to report 5 new mutations in ABHD12.

  3. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function.

  4. ABHD12 mutations are not a frequent cause of ataxia (show USP14 Antibodies) at least in Southern Italy

  5. After the identification of the ABHD12 mutation in this family, one patient underwent neurological examination which revealed ataxia (show USP14 Antibodies), but no polyneuropathy

  6. Data show that the three hydrolases are genuine MAG (show MAG Antibodies) lipases; medium-chain saturated MAGs were the best substrates for hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and 2-isomers of arachidonoylglycerol.

  7. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia (show USP14 Antibodies), retinitis pigmentosa, and cataract disease.

ABHD12 Antigen Profile

Protein Summary

This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with ABHD12

  • abhydrolase domain containing 12 (ABHD12) antibody
  • abhydrolase domain containing 12 (CC1G_02966) antibody
  • abhydrolase domain containing 12 (PTRG_02160) antibody
  • abhydrolase domain containing 12 (abhd12) antibody
  • abhydrolase domain containing 12 (LOC100342158) antibody
  • abhydrolase domain containing 12 (Abhd12) antibody
  • 1500011G07Rik antibody
  • 6330583M11Rik antibody
  • ABHD12 antibody
  • ABHD12A antibody
  • AI431047 antibody
  • AW547313 antibody
  • BEM46L2 antibody
  • C20orf22 antibody
  • dJ965G21.2 antibody
  • PHARC antibody

Protein level used designations for ABHD12

abhydrolase domain containing 12 , monoacylglycerol lipase ABHD12-like , 2-arachidonoylglycerol hydrolase , abhydrolase domain-containing protein 12 , monoacylglycerol lipase ABHD12

GENE ID SPECIES
477004 Canis lupus familiaris
744997 Pan troglodytes
6012413 Coprinopsis cinerea okayama7130
6339600 Pyrenophora tritici-repentis Pt-1C-BFP
100380988 Xenopus laevis
100449601 Pongo abelii
100466451 Ailuropoda melanoleuca
100342158 Oryctolagus cuniculus
76192 Mus musculus
499913 Rattus norvegicus
26090 Homo sapiens
768242 Bos taurus
421249 Gallus gallus
Selected quality suppliers for anti-ABHD12 (ABHD12) Antibodies
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