ABHD12 antibody (AA 200-280)

Catalog No. ABIN7213428

The Rabbit Polyclonal anti-ABHD12 antibody (ABIN7213428) specifically detects ABHD12 in WB, ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ABHD12 antibody (AA 200-280) (ABIN7213428)

Target: ABHD12 (Abhydrolase Domain Containing 12 (ABHD12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABHD12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ABHD12 Antibody

Binding Specificity: AA 200-280

Purpose: Rabbit Anti-ABHD12 Polyclonal Antibody

Specificity: ABHD12 Polyclonal Antibody detects endogenous levels of ABHD12 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human ABHD12 at AA range: 200-280

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ABHD12

Target: ABHD12 (Abhydrolase Domain Containing 12 (ABHD12))

Alternative Name: ABHD12

Background: ABHD12, C20orf22, Monoacylglycerol lipase ABHD12, 2-arachidonoylglycerol hydrolase, Abhydrolase domain-containing protein 12ABHD12 encodes an enzyme (abhydrolase domain containing 12) that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in ABHD12 are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for ABHD12.

Molecular Weight: 45kD

Gene ID: 26090

UniProt: Q8N2K0