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ALCAM encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. Additionally we are shipping CD166 Antibodies (301) and CD166 Proteins (39) and many more products for this protein.
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Human CD166 ELISA Kit for Sandwich ELISA - ABIN414348
Al-Shehri, Abd El Azeem: Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Saudi Breast Cancer Patients as Prognostic and Predictive Indicator. in Breast cancer : basic and clinical research 2015
Alcama mediates Edn1 (show EDN1 ELISA Kits) signaling during zebrafish cartilage morphogenesis.
The cell-adhesion molecule (show MCAM ELISA Kits) Alcam is required for proper nephrogenesis and functions downstream of Fzd3 (show FZD3 ELISA Kits) during embryonic kidney development.
No significant association between ALCAM expression and survival data was observed for all tumors
Our data indicate that Gal-8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms. A novel heterophilic interaction between ALCAM and Gal-8 is demonstrated here, suggesting its physiologic relevance in the biology of breast cancer cells
CD166 functions as a risk factor for cancers, and the alterations of its different functional isoforms were observed to correlate with specific or interplayed clinical outcomes.
The results highlight the potential of ALCAM as a recurrent biomarker in early-stage endometrioid endometrial cancer and point to ALCAM as an important molecule in endometrial cancer dissemination by regulating cell migration, invasion, and metastasis.
MiR (show MLXIP ELISA Kits)-148a and miR (show MLXIP ELISA Kits)-152 can sensitize tamoxifen-resistant MCF-7 breast cancer cells to tamoxifen via downregulating ALCAM.
CHIP directly regulates the stability of CD166 protein through the ubiquitin proteasome system.
ALCAM is overexpressed on the surface of Human T-lymphotropic virus type 1-infected lymphocytes, both in chronically infected cell lines and in primary infected CD4 (show CD4 ELISA Kits)(+) T lymphocytes.
ALCAM is upregulated in pancreatic stellate cells of pancreatic cancer tissues, suggesting a potential role of ALCAM in regulating pancreatic cancer cell-pancreatic stellate cells interactions.
PRMT1 (show PRMT1 ELISA Kits) is overexpressed in human melanoma, and may regulate tumor growth and metastasis via targeting ALCAM.
SFMSCs increased through upregulation of the activated lymphocyte cell adhesion molecule (show MCAM ELISA Kits) (ALCAM) and N-cadherin (show CDH2 ELISA Kits) by microRNA-192 and -218 downregulation, similar to BMMSCs and ADMSCs.
Analysis of KRAS mutation combined with immunohistochemical expression of CD44 (show CD44 ELISA Kits) and CD166 identified subgroups of patients with colon adenocarcinoma at higher risk of lymph node involvement by the tumor and development of liver and lung metastasis.
demonstrates for the first time the in vivo contribution of ALCAM to angiogenesis and reveals a novel role of stromally expressed ALCAM in supporting tumor growth and metastatic spread
Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers
Data indicate that the CD166/AKT (show AKT1 ELISA Kits) axis modulates tumorigenesis via promotion of phosphorylation and facilitation of degradation, ubiquitination and cytosolic accumulation of FOXO (show FOXO3 ELISA Kits) proteins in liver cancer cells.
ALCAM stably interacts with actin by binding to syntenin-1 (show SDCBP ELISA Kits) and ezrin (show EZR ELISA Kits).
CD166/ALCAM (ALCAM) is a close structural and functional homolog of RAGE (show AGER ELISA Kits); it shows that binding of S100B (show S100B ELISA Kits) to CD166/ALCAM induces dose- and time-dependent expression of NF-kappaB (show NFKB1 ELISA Kits) family members in wild type and RAGE (show AGER ELISA Kits)-deficient mouse endothelial cells.
Activated Leukocyte Cell Adhesion Molecule (ALCAM) or CD166 expression on osteoblasts is directly correlated with Runx2 (show RUNX2 ELISA Kits) expression and high hematopoiesis enhancing activity.
Behavioral deficits caused by prolonged IFN alpha (show IFNA ELISA Kits) treatment were not prevented by blocking ALCAM, which is involved in immune cell entry to the brain.
novel role for ALCAM in stabilizing LEC-LEC interactions and in the organization and function of the LV network.
The presence of CD166 on prostate stem/progenitors and castration resistant sub-populations suggest that it is a cell surface molecule with the potential for targeted delivery of human prostate cancer therapeutics.
CD166 is highly expressed within the endogenous intestinal stem cell niche
ALCAM up-regulation by hypercholesterolemia suggests a side-specific spatial role in the recruitment of leukocytes to aortic valve sclerosis sites.
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
CD166 antigen homolog A
, DM-GRASP homolog
, zn5 / zn-5 antigen
, zn8 / zn-8 antigen
, activated leukocyte cell adhesion molecule
, CD166 antigen
, DM-GRASP II
, CD166 antigen-like
, CD166 antigen homolog
, SB-10 antigen
, activated leucocyte cell adhesion molecule
, BEN glycoprotein
, SC1 glycoprotein