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Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 Proteins (ASPSCR1)

The protein encoded by ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). Additionally we are shipping ASPSCR1 Antibodies (77) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ASPSCR1 ASPSCR1 691026  
ASPSCR1 79058 Q9BZE9
ASPSCR1 68938 Q8VBT9
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Top ASPSCR1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Pseudomonas syringae pv. tomato His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$273.57
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) General Un-conjugated   10 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ASPSCR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Interaction Partners

Human Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) interaction partners

  1. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der (show GDF3 Proteins)(17)t(X:17)(p11 (show S100A10 Proteins):q25), resulting in the fusion of the TFE3 (show TFE3 Proteins) transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.

  2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 (show TFE3 Proteins) from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  3. ASPL is a cofactor of the hexameric ATPase complex, known as p97 (show EIF4G2 Proteins). The central area in ASPL, containing both a SHP (show LAMC1 Proteins) box and a UBX domain, is required for binding to the p97 (show EIF4G2 Proteins) N-domain.

  4. Results support a gain-of-function role for ASPSCR1-TFE3 (show TFE3 Proteins) contributing to proliferation and survival of cancer cells.

  5. Promotes methylation of VCP by METTL21D

  6. Data support a model in which TUG controls p97 (show EIF4G2 Proteins) oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types.

  7. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 (show TFE3 Proteins) fusion transcript would be the highly effective diagnostic technique.

  8. Immuno-detection of TFE3 (show TFE3 Proteins) and RT-PCR-based identification of ASPL/TFE3 (show TFE3 Proteins) fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma.

  9. Immunohistochemical discrimination between the ASPL-TFE3 (show TFE3 Proteins) fusion proteins of alveolar soft part sarcoma

Mouse (Murine) Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) interaction partners

  1. Insulin (show INS Proteins) acts through TUG proteins to control IRAP (show IL1RN Proteins) targeting, similar to GLUT4 (show SLC2A4 Proteins); the activity of vasopressin (show AVP Proteins), an IRAP (show IL1RN Proteins) substrate, is reduced in mice with disrupted TUG action in muscle.

  2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 (show TFE3 Proteins) from human alveolar soft part sarcoma (ASPS (show DARS Proteins)) generated a model that recapitulates the human tumor histologically and by expression profile.

  3. Data indicate that insulin (show INS Proteins) stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4 (show SLC2A4 Proteins))) to translocate GLUT4 (show SLC2A4 Proteins) in muscle.

  4. Data suggest a model whereby insulin (show INS Proteins) stimulates TUG cleavage to liberate GLUT4 (show SLC2A4 Proteins) storage vesicles from the Golgi matrix, which promotes GLUT4 (show SLC2A4 Proteins) translocation to the cell surface and enhances glucose uptake.

  5. TUG traps endocytosed GLUT4 (show SLC2A4 Proteins) and tethers it intracellularly, and insulin (show INS Proteins) mobilizes this pool of retained GLUT4 (show SLC2A4 Proteins) by releasing this tether

  6. insulin (show INS Proteins)-stimulated dissociation of TUG and GLUT4 (show SLC2A4 Proteins) as an important action by which insulin (show INS Proteins) stimulates glucose uptake.

ASPSCR1 Protein Profile

Protein Summary

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X\;17)(p11\;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Gene names and symbols associated with ASPSCR1

  • alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1)
  • alveolar soft part sarcoma chromosome region, candidate 1 (aspscr1)
  • alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1)
  • alveolar soft part sarcoma chromosome region, candidate 1 (Bm1_55980)
  • 1190006K01Rik protein
  • ASPC protein
  • ASPCR1 protein
  • ASPL protein
  • ASPS protein
  • RCC17 protein
  • TUG protein
  • UBXD9 protein
  • UBXN9 protein

Protein level used designations for ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1 , hypothetical protein LOC495145 , tether containing UBX domain for GLUT4 , UBX domain protein 9 , UBX domain-containing protein 9 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein , alveolar soft part sarcoma locus , renal cell carcinoma gene on chromosome 17 , renal cell carcinoma, papillary, 17 , renal papillary cell carcinoma protein 17 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog , tether, containing a UBX domain, for GLUT4

GENE ID SPECIES
417384 Gallus gallus
495145 Xenopus laevis
691026 Rattus norvegicus
733865 Xenopus (Silurana) tropicalis
6106077 Brugia malayi
515670 Bos taurus
79058 Homo sapiens
68938 Mus musculus
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