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ANAPC7 encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. Additionally we are shipping ANAPC7 Kits (8) and ANAPC7 Proteins (3) and many more products for this protein.
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Chicken Polyclonal ANAPC7 Primary Antibody for IHC, WB - ABIN2776904
Turnell, Stewart, Grand, Rookes, Martin, Yamano, Elledge, Gallimore: The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. in Nature 2005
Human Polyclonal ANAPC7 Primary Antibody for EIA, WB - ABIN499303
Peters: The anaphase promoting complex/cyclosome: a machine designed to destroy. in Nature reviews. Molecular cell biology 2006
The results showed that APC2 and APC7 subunits were both over expressed in cancer cell lines
Data indicate that additional density present in the anaphase-promoting complex (APC (show APC Antibodies)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7, a subunit specific to vertebrate APC (show APC Antibodies)/C.
Studies indicate that APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies)) is required to maintain genomic stability.
dysregulation of APC (show APC Antibodies) activity, possibly through downregulation of APC7, may be associated with tumorigenesis in breast cancer
APC5 (show ANAPC5 Antibodies) and APC7 suppress E1A (show BCKDHA Antibodies)-mediated transformation in a CBP/p300 (show CREBBP Antibodies)-dependent manner, indicating that these components of the APC (show APC Antibodies)/C may be targeted during cellular transformation
Expression of ANAPC7 in fibroadenomas and phylloides tumors of breast is reported.
The crystal structure of quad mutant of nApc7 (N-terminal fragment, residues 1-147) of human Apc7 at a resolution of 2.5 A, is reported.
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene.
anaphase promoting complex subunit 7
, anaphase-promoting complex subunit 7
, cyclosome subunit 7
, prediabetic NOD sera-reactive autoantigen