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Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Additionally we are shipping Angiomotin Like 2 Antibodies (24) and Angiomotin Like 2 Kits (6) and many more products for this protein.
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Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 Proteins) and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1 (show LEF1 Proteins).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (show SRC Proteins), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
mTORC2 (show CRTC2 Proteins)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (show YAP1 Proteins) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (show AMOT Proteins)) and angiomotin (show AMOT Proteins)-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (show AMOT Proteins) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (show TAZ Proteins) and modulates transcriptional activity of TAZ (show TAZ Proteins).
AMOTL2 is as a novel activator of LATS2.
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (show AMOT Proteins), Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri (show POSTN Proteins)-implantation period.
Data show that MUPP1 interacts with angiomotin (Amot (show AMOT Proteins)), JEAP/Amot (show AMOT Proteins)-like 1 and MASCOT/Amot (show AMOT Proteins)-like 2, and that all the Amot (show AMOT Proteins)/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
angiomotin like 1
, angiomotin-like protein 1
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 1-like
, angiomotin-like protein 2-like
, Leman coiled-coil protein
, angiomotin-like protein 2