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Angiomotin Like 2 Proteins (AMOTL2)

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Additionally we are shipping Angiomotin Like 2 Antibodies (24) and Angiomotin Like 2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AMOTL2 51421 Q9Y2J4
Rat AMOTL2 AMOTL2 65157  
AMOTL2 56332 Q8K371
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Top Angiomotin Like 2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

AMOTL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Angiomotin Like 2 (AMOTL2) Interaction Partners

Zebrafish Angiomotin Like 2 (AMOTL2) interaction partners

  1. Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (show YAP1 Proteins) and the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) effector Lef1 (show LEF1 Proteins).

  2. amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.

  3. We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.

  4. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells

  5. Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (show SRC Proteins), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.

Human Angiomotin Like 2 (AMOTL2) interaction partners

  1. study reports for the first time that USP9X (show USP9X Proteins) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (show YAP1 Proteins) inhibition

  2. mTORC2 (show CRTC2 Proteins)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (show YAP1 Proteins) signaling.

  3. AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.

  4. Scaffold proteins angiomotin (Amot (show AMOT Proteins)) and angiomotin (show AMOT Proteins)-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) by preventing their nuclear translocation.

  5. These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (show AMOT Proteins) family members through direct phosphorylation.

  6. These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.

  7. AMOTL2 interacts with TAZ (show TAZ Proteins) and modulates transcriptional activity of TAZ (show TAZ Proteins).

  8. AMOTL2 is as a novel activator of LATS2.

  9. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells

Mouse (Murine) Angiomotin Like 2 (AMOTL2) interaction partners

  1. mTORC2 (show CRTC2 Proteins)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (show YAP1 Proteins) signaling.

  2. AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.

  3. Amot (show AMOT Proteins), Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri (show POSTN Proteins)-implantation period.

  4. Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells

  5. Data show that MUPP1 interacts with angiomotin (Amot (show AMOT Proteins)), JEAP/Amot (show AMOT Proteins)-like 1 and MASCOT/Amot (show AMOT Proteins)-like 2, and that all the Amot (show AMOT Proteins)/JEAP family proteins also interacted with Patj, a close relative of MUPP1.

Angiomotin Like 2 (AMOTL2) Protein Profile

Protein Summary

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.

Gene names and symbols associated with Angiomotin Like 2 Proteins (AMOTL2)

  • angiomotin like 1 (AMOTL1)
  • angiomotin like 2a (amotl2a)
  • angiomotin like 1 (amotl1)
  • angiomotin like 1 (LOC100348712)
  • angiomotin like 2 (AMOTL2)
  • angiomotin like 2 (amotl2)
  • angiomotin like 2 (Amotl2)
  • angiomotin-like 2 (Amotl2)
  • amotl2 protein
  • AW549739 protein
  • C79691 protein
  • cb308 protein
  • DKFZp468L222 protein
  • jeap protein
  • Lccp protein
  • MASCOT protein
  • mKIAA0989 protein
  • sb:cb308 protein
  • wu:fc41b07 protein
  • wu:fc64c06 protein

Protein level used designations for Angiomotin Like 2 Proteins (AMOTL2)

angiomotin like 1 , angiomotin-like protein 1 , angiomotin like 2 , angiomotin-like 2a , angiomotin-like protein 1-like , angiomotin-like protein 2-like , Leman coiled-coil protein , angiomotin-like protein 2

GENE ID SPECIES
428091 Gallus gallus
451491 Pan troglodytes
558920 Danio rerio
100145436 Xenopus (Silurana) tropicalis
100158429 Xenopus laevis
100172648 Pongo abelii
100348712 Oryctolagus cuniculus
100475663 Ailuropoda melanoleuca
718868 Macaca mulatta
100379727 Xenopus (Silurana) tropicalis
100523696 Sus scrofa
460712 Pan troglodytes
100540953 Meleagris gallopavo
51421 Homo sapiens
65157 Rattus norvegicus
56332 Mus musculus
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