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The protein encoded by ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme.
ACE (show ACE Antibodies) and ACE2 expression at the mRNA and protein levels are significantly increased in the myocardium of patients with heart failure.
Multivariable regression analysis revealed that urinary L-FABP (show FABP1 Antibodies) and urinary albumin (show ALB Antibodies)/ creatinine ratio were significantly associated with urinary ACE2 levels.
ACE2 and Ang-(1 (show ANGPT1 Antibodies)-7) significantly inhibit early atherosclerotic lesion formation via protection of endothelial function and inhibition of inflammatory response.
SIT1 (show SIT1 Antibodies), B(0)AT1 (show SLC6A19 Antibodies) and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes.
ACE-2 is expressed in fetal human lung fibroblasts but is significantly decreased by hyperoxic gas
urinary ACE2 increased in type 2 diabetic patients with various degrees of albuminuria
soluble ACE2 is involved in the pathomechanism of hypertension and heart failure.
Decrease in circulating ACE2 activity was associated with cardiovascular disease in patients with chronic kidney disease.
By genetic replenishment of ACE2 and pharmaceutical use of ARB (show BEST1 Antibodies), restored ACE2 level mitigated GBC growth. Our results supported the rationale for the use of ARB (show BEST1 Antibodies) in GBC patients for potential therapeutic benefit
There is no clear association between ACE2 gene A9570G polymorphisms and childhood primary nephrotic syndrome.
ACE2 regulates vascular function by modulating nitric oxide release.
MAS (show MAS1 Antibodies) receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS (show MAS1 Antibodies) axis functionality
ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin (show INS Antibodies) resistance.
a Mas (show MAS1 Antibodies) receptor-mediated mechanism may stimulate pancreatic cell development
ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE Antibodies)-mutant mice through modulation of the nephrin (show NPHS1 Antibodies), NOX4 (show NOX4 Antibodies) and TNF-alpha (show TNF Antibodies)-TNFRSF1A (show TNFRSF1A Antibodies) signaling.
Hydronephrosis led to an increase of ACE (show ACE Antibodies) level and a decrease of ACE2 and Mas (show MAS1 Antibodies) receptor in the heart.
Overexpression of ADAM17 (show ADAM17 Antibodies) increases shed ACE2 and decreases cellular ACE2 levels in pancreatic islets. Whereas ADAM17 (show ADAM17 Antibodies) has the ability to shed ACE2, ADAM17 (show ADAM17 Antibodies) does not deplete ACE2 from pancreatic islets in diabetic db/db (show LEPR Antibodies) mice.
These results demonstrate a critical role for endogenous ACE2 in the adaptive beta-cell hyperinsulinemic response to High Fat feeding through regulation of beta-cell proliferation and growth.
ACE2 deficiency worsened the influenza pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1 (show AGTR1 Antibodies)).
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively
This study produced the full-length porcine ACE2 cDNA sequence and found polyunsaturated fatty acids could downregulate the expression of ACE2.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
, angiotensin-converting enzyme 2
, angiotensin-converting enzyme homolog
, metalloprotease MPROT15
, peptidyl-dipeptidase A
, angiotensin I converting enzyme 2
, anigotensin-converting enzyme-related carboxypeptidase
, renal angiotensin-converting enzyme 2