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Ankyrin Repeat and SOCS Box Containing 4 Proteins (ASB4)

The protein encoded by ASB4 is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. Additionally we are shipping ASB4 Antibodies (36) and ASB4 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ASB4 ASB4 500017  
ASB4 51666 Q9Y574
ASB4 65255 Q9WV71
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Top ASB4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ASB4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Ankyrin Repeat and SOCS Box Containing 4 (ASB4) Interaction Partners

Human Ankyrin Repeat and SOCS Box Containing 4 (ASB4) interaction partners

  1. Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis.

Mouse (Murine) Ankyrin Repeat and SOCS Box Containing 4 (ASB4) interaction partners

  1. Expression of imprinted gene Asb4 was unregulated in haploid androgenetic/gynogenetic blastocysts.

  2. In functional endothelial co-culture assays, JAR (show MYO6 Proteins) cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta.

  3. The interaction of Asb-4 with IRS4 (show IRS4 Proteins) in cell lines mediates the degradation of IRS4 (show IRS4 Proteins) and decreases insulin (show INS Proteins) signaling.

  4. Tumor necrosis factor alpha (show TNF Proteins) upregulates ankyrin repeat and suppressor of cytokine signalling (show SOCS1 Proteins) box protein 4 expression.

  5. Asb-4 is a key regulatory protein in the central nervous system, involved in the control of feeding behavior and metabolic rate.

  6. Asb4 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray.

  7. Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis.

  8. The present study demonstrates that Asb-4 interacts with GPS1 (show GPS1 Proteins) and inhibits JNK (show MAPK8 Proteins) activity.

  9. These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis.

ASB4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.

Gene names and symbols associated with ASB4

  • ankyrin repeat and SOCS box-containing 4 (Asb4)
  • ankyrin repeat and SOCS box containing 4 (ASB4)
  • 8430401O13Rik protein
  • ASB-4 protein
  • AV117194 protein
  • AW060255 protein

Protein level used designations for ASB4

ankyrin repeat and SOCS box protein 4 , ankyrin repeat and SOCS box-containing protein 4 , ankyrin repeat and SOCS box-containing 4 , ASB-4

GENE ID SPECIES
500017 Rattus norvegicus
482309 Canis lupus familiaris
100523325 Sus scrofa
535831 Bos taurus
51666 Homo sapiens
65255 Mus musculus
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