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APLN encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. Additionally we are shipping Apelin Kits (30) and Apelin Proteins (10) and many more products for this protein.
Showing 10 out of 88 products:
Human Monoclonal Apelin Primary Antibody for ELISA, WB - ABIN393279
Meral, Tascilar, Karademir, Tanju, Cekmez, Ipcioglu, Ercin, Gocmen, Dogru: Elevated plasma levels of apelin in children with type 1 diabetes mellitus. in Journal of pediatric endocrinology & metabolism : JPEM 2010
Show all 5 references for ABIN393279
Human Polyclonal Apelin Primary Antibody for ELISA, IF - ABIN347115
Daviaud, Boucher, Gesta, Dray, Guigne, Quilliot, Ayav, Ziegler, Carpene, Saulnier-Blache, Valet, Castan-Laurell: TNFalpha up-regulates apelin expression in human and mouse adipose tissue. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
Show all 4 references for ABIN347115
Human Polyclonal Apelin Primary Antibody for EIA, IHC (fro) - ABIN1105402
Castan-Laurell, Boucher, Dray, Daviaud, Guigné, Valet: Apelin, a novel adipokine over-produced in obesity: friend or foe? in Molecular and cellular endocrinology 2006
Show all 2 references for ABIN1105402
Human Polyclonal Apelin Primary Antibody for WB - ABIN522328
Li, Takai, Yuge, Furukawa, Tsuno, Tsukamoto, Kong, Moriyama, Narahara: Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells. in Cancer letters 2010
Apelin signaling regulates lymphatic development by promoting serine-threonine kinase Akt/protein kinase B (show AKT1 Antibodies) activity in a VEGF-C (show VEGFC Antibodies)/VEGF receptor (show FLT1 Antibodies) 3-independent manner during zebrafish embryogenesis.
Apelin knockdown inhibits both hypoxia-induced endothelial cell proliferation in vitro and hypoxia-induced vessel regeneration in the caudal (show CAD Antibodies) fin regeneration of zebrafish.
miR (show MLXIP Antibodies)-503 promotes cardiac fibrosis via miR (show MLXIP Antibodies)-503-Apelin-13-TGF-beta (show TGFB1 Antibodies)-CTGF (show CTGF Antibodies)-collagen production pathway.
Apelin directly interferes with thrombin-mediated signaling pathways and platelet activation, secretion, and aggregation, but not with ADP and thromboxane A2-mediated pathways.
Apelin regulates inflammatory response, diminishes inflammatory remote organ damage and improves survival in an experimental model of burn sepsis, which is at least partly mediated by a phosphatidylinositol 3-kinase/protein kinase B (show AKT1 Antibodies) dependent pathway.
apelin is a potential activator of inflammation factors through the PI3K/Akt (show AKT1 Antibodies) and Erk (show EPHB2 Antibodies) signaling pathway and is potential therapeutically relevant to inflammatory responses of microglia cells
we showed the effect of Apelin on RAW264.7 macrophage under normal and hypoxic condition, which could further influence the angiogenesis and inflammation process that promoted by macrophages.
PDL- and Cer (show CBLN1 Antibodies)-induced CP resulted in increased production of the pancreatic BMP2 (show BMP2 Antibodies), apelin, and PTHrP (show PTHLH Antibodies) signaling systems and that significant cross talk occurred among pancreatic BMP2 (show BMP2 Antibodies), apelin, and PTHrP (show PTHLH Antibodies)
Therapeutic potential of apelin to prevent myocardial metabolic abnormalities in heart failure paired with obesity.
Data suggest that CTRP3 (cartducin) up-regulates expression and secretion of adipokines (adiponectin, leptin, visfatin, and apelin) in adipocytes; these responses to CTRP3 are down-regulated by insulin resistance or inhibition of AMPK signaling.
apelin is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 (show SFRP1 Antibodies) by apelin receptor (show APLNR Antibodies)(+) ECs
Findings demonstrate a stimulatory role for the islet cell apelin-APJ (show APLNR Antibodies) signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced beta-cell hyperplasia.
APJ receptor (show APLNR Antibodies) in granulosa cells and both apelin and the APJ receptor (show APLNR Antibodies) in theca tissues are expressed in bovine ovary.
The data suggest that apelin/APJ (show APLNR Antibodies) system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.
The optimal gene-gene interaction model for both males and females with regard to hypertension was apelin rs3761581-apelin rs3115757-APJ (show APLNR Antibodies) rs7119375. In conclusion, gene polymorphisms of the apelin-APJ (show APLNR Antibodies) system are associated with susceptibility to hypertension.
Lower apelin and higher visfatin (show NAMPT Antibodies) plasma levels in high normal blood pressure subjects compared to normal or optimal BP individuals could partially explain the higher cardiovascular risk of the high normal BP group.
apelin 13 levels are elevated in patients with PE. These results suggest that apelin may be a novel biomarker and a potential therapeutic target in patients with acute PE in the future.
Up-regulation of apelin and APJ (show APLNR Antibodies) expression plays an important role in cardioprotection from myocardial ischemia/reperfusion injury.
There was no significant change in plasma apelin levels in acute pulmonary embolism.
The concentrations of gastric peptide(Ghrelin (show GHRL Antibodies) and obestatin)and adipocytokines(omentin (show ITLN1 Antibodies) and Apelin ) across all subgroups were lower than in the control group. The differences were statistically significant (p < 0.0001), which may be of importance in the development of the disease complications
Resequencing of the apelin gene in subjects stratified by low or high apelin levels identified five APLN variants in an European population. No association was found between the most frequent variant, diabetes, and metabolic parameters.
These findings suggested that Apelin/APLNR (show APLNR Antibodies) signaling may be used as a potential therapeutic target for hypoxic/ischemic injury.
apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK (show EPHB2 Antibodies) and PI3-K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway
Genetic variants in the apelin gene are significantly associated with the risk of coronary artery disease in the Turkish population.
Pig Apelin mRNA was sequenced.
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
, apelin, AGTRL1 ligand
, APJ endogenous ligand
, apelin; peptide ligand for APJ receptor
, AGTRL1 ligand