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Acts as an antizyme inhibitor and prevents antizyme- dependent degradation of ornithine decarboxylase. Additionally we are shipping Arginine Decarboxylase Antibodies (15) and Arginine Decarboxylase Proteins (3) and many more products for this protein.
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The high expression of AZIN2 in various cells with secretory or vesicle transport activity indicates that the polyamine metabolism regulated by AZIN2
ODC (show ODC1 ELISA Kits) activity is mostly linked to cell proliferation, whereas its regulation by AZIN2 in post-mitotically differentiated neurons of the brain apparently serves different purposes.
Both endogenous and FLAG-tagged AZIN2 localize to post-Golgi vesicles of the secretory pathway. Immuno-electron microscopy revealed that the vesicles associate mainly with the trans-Golgi network.
AZIN2 expression appears to be restricted to brain and testis and it is a labile protein degraded by a ubiquitin-dependent mechanism.
localization of AZIN2 implies possible involvement in the gonadal synthesis and/or release of steroid hormones.
in contrast to human ODCp, mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity
AZIN2 may have a role in the modulation of reproductory and secretory functions.
expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neural stem cells
granule subtype-specific expression and its induction after MC activation suggest a role for AZIN2 as a local, in situ regulator of polyamine biosynthesis in association with serotonin-containing granules of mast cells
AZIN2 affects polyamine homeostasis not only by increasing ornithine decarboxylase (show ODC1 ELISA Kits) activity but also by stimulating polyamine uptake, through negating the inhibitory effect of the antizymes
differences in the subcellular distribution of AZIN1 (show AZIN1 ELISA Kits) and AZIN2
Acts as an antizyme inhibitor and prevents antizyme- dependent degradation of ornithine decarboxylase. Does not appear to possess arginine decarboxylase or ornithine decarboxylase activity.
, ornithine decarboxylase-like protein
, ODC antizyme inhibitor-2
, antizyme inhibitor 2
, ornithine decarboxylase like
, ornithine decarboxylase-paralog
, arginine decarboxylase-like protein
, ODC 2
, ornithine decarboxylase 2
, ornithine decarboxylase-2