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Asporin Proteins (ASPN)

ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. Additionally we are shipping Asporin Antibodies (48) and Asporin Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASPN 54829 Q9BXN1
ASPN 66695 Q99MQ4
Rat ASPN ASPN 306805  
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Top Asporin Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days

ASPN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Asporin (ASPN) Interaction Partners

Pig (Porcine) Asporin (ASPN) interaction partners

  1. Mapping of the OGN (show OGN Proteins) and ASPN genes and association with growth and carcass traits.

Human Asporin (ASPN) interaction partners

  1. To test the associations of ASPN variations with risk of subsequent oncologic outcomes.

  2. Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (show EGFR Proteins) signaling pathway.

  3. Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.

  4. this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA

  5. Osteomodulin (show OMD Proteins), osteoglycin (show OGN Proteins), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.

  6. Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.

  7. This meta-analysis shows that the ASPN D14, D13, and D15 (show MRPL16 Proteins) alleles are not associated with the development of osteoarthritis in Europeans and Asians. [Meta-Analysis]

  8. A meta-analysis suggest that the D-repeat of asporin gene (ASPN) may not be a major susceptibility locus in the Caucasian and Asian populations with knee osteoarthritis.

  9. polymorphisms within the ASPN gene could influence knee osteoarthritis susceptibility

  10. D14-PLAP-1 (show ALP Proteins) suppressed BMP-2 (show BMP2 Proteins) signal transduction more efficiently than D13-PLAP-1 (show ALP Proteins); stronger affinity of D14-PLAP-1 (show ALP Proteins) protein to BMP-2 (show BMP2 Proteins) compared with D13-PLAP-1 (show ALP Proteins) protein. D repeat polymorphism of PLAP-1/asporin has influence on functions of PDL cells.

Mouse (Murine) Asporin (ASPN) interaction partners

  1. inhibition of TLR2- and TLR4 (show TLR4 Proteins)-induced inflammatory responses and binding abilities to TLR2 and TLR4 (show TLR4 Proteins)

  2. positively regulates FGF-2 (show FGF2 Proteins) activity through a direct interaction

  3. Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (show MMRN1 Proteins) and TGF-beta1 (show TGFB1 Proteins) and thereby modulates interactions between TGF-beta (show TGFB1 Proteins) and its signaling receptors.

  4. PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (show BMP2 Proteins) activity to prevent the periodontal ligament from developing non-physiological mineralization

  5. The findings indicate that TGF-beta1 (show TGFB1 Proteins) induces ASPN through Smad3 (show SMAD3 Proteins) but that this induction is indirect.

  6. Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (show BMP2 Proteins) interaction.

Xenopus laevis Asporin (ASPN) interaction partners

  1. The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.

Asporin (ASPN) Protein Profile

Protein Summary

This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with Asporin Proteins (ASPN)

  • asporin (LRR class 1) (aspn)
  • asporin (ASPN)
  • asporin (Aspn)
  • asporin (aspn)
  • 4631401G09Rik protein
  • AA986886 protein
  • aspnl protein
  • bgl3 protein
  • os3 protein
  • plap-1 protein
  • plap1 protein
  • slrr1c protein
  • wu:fk08c11 protein
  • zgc:109936 protein

Protein level used designations for Asporin Proteins (ASPN)

asporin , biglycan-like protein 3 , asporin (LRR class 1) , asporin proteoglycan , periodontal ligament associated protein 1 , small leucine-rich protein 1C , periodontal ligament-associated protein 1

65228 Danio rerio
739953 Pan troglodytes
100054817 Equus caballus
100192319 Sus scrofa
100410747 Callithrix jacchus
100446487 Pongo abelii
100600227 Nomascus leucogenys
54829 Homo sapiens
66695 Mus musculus
495030 Xenopus laevis
415954 Gallus gallus
610685 Canis lupus familiaris
507990 Bos taurus
306805 Rattus norvegicus
100732832 Cavia porcellus
100511749 Sus scrofa
101108885 Ovis aries
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