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Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Additionally we are shipping Ataxin 1-Like Proteins (2) and many more products for this protein.
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Both ATXN1 (show ATXN1 Antibodies) and BOAT1 bind to the promoter region of Hey1 (show HEY1 Antibodies) and inhibit the transcriptional output of Notch (show NOTCH1 Antibodies) through direct interactions with CBF1 (show RBPJ Antibodies), a transcription factor that is crucial for the Notch (show NOTCH1 Antibodies) pathway.
Boat is an in vivo binding partner of ataxin-1 (show ATXN1 Antibodies) whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia (show USP14 Antibodies) type 1 animals
Results provide genetic evidence that the selective neuropathology of Spinocerebellar ataxia (show USP14 Antibodies) type 1 arises from modulation of a core functional activity of ataxin-1 (show ATXN1 Antibodies)
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity).
, brother of ATXN1
, brother of ataxin-1