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Axin 2 Proteins (AXIN2)

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. Additionally we are shipping AXIN2 Antibodies (76) and AXIN2 Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat AXIN2 AXIN2 29134 O70240
AXIN2 8313 Q9Y2T1
AXIN2 12006 O88566
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Top AXIN2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$707.52
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details

AXIN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Axin 2 (AXIN2) Interaction Partners

Human Axin 2 (AXIN2) interaction partners

  1. miR (show MLXIP Proteins)-374a functions as an oncogene (show RAB1A Proteins) in osteosarcoma, and the miR (show MLXIP Proteins)-374a/Axin2 axis might represent a potential therapeutic target for OS intervention.

  2. Flow cytometrically sorted CA9 (show CA9 Proteins)+ population showed increased mRNA level of a Wnt (show WNT2 Proteins) signaling factor AXIN2. In conclusion, these observations indicate that CA9 (show CA9 Proteins) expression in normal crypt base cells has association with intestinal epithelial stemness

  3. Increase in AXIN2 level expression is associated with breast cancer.

  4. rs9675316 located on chr17q23-a24 (show CD164 Proteins) near the AXIN2 gene was the most significantly associated with hallux valgus in males in genome-wide association meta-analyses.

  5. Low AXIN2 was independently associated with more aggressive Prostate cancer , biochemical recurrence, and metastasis-free survival after Prostatectomies .

  6. Axin2, a tumor suppressor, exhibited a marked inhibitory effect on Eca109 cell growth. The results identified a new role of miR (show MLXIP Proteins)-374a in esophageal cancer involving Axin2 suppression

  7. study supports the relationship between AXIN2 mutation and non-syndromic oligodontia and extends the mutation spectrum of the AXIN2 gene.

  8. AXIN2 rs2240308 polymorphism significantly and race-specifically correlates with decreased cancer risk (Meta-Analysis)

  9. Suggest that miR (show MLXIP Proteins)-107 could promote HCC (show FAM126A Proteins) cell proliferation via targeting Axin2.

  10. Our data suggest the AXIN2 1989G>A mutation may not have solely a loss-of-function role in colorectal cancer

Zebrafish Axin 2 (AXIN2) interaction partners

  1. beta-catenin1 cannot revert the ich (show ACE Proteins) phenotype because it may be under the control of a GSK3beta-independent mechanism that required Axin's RGS (show PITX2 Proteins) domain function.

Mouse (Murine) Axin 2 (AXIN2) interaction partners

  1. The role of Axin-2 signaling in the proliferation of undifferentiated spermatogonia in the adult mouse testis

  2. Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  3. Axin2-expressing prostatic cells express epithelial cell markers and are able to expand cell lineage during prostatic development and maturation.

  4. Axin1 (show AXIN1 Proteins) and Axin2 do not have equivalent functions in satellite cells, but are both involved in repression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling to maintain proliferation and contribute to controlling timely myogenic differentiation.

  5. These data demonstrate a dominant role for Runx2 (show RUNX2 Proteins) in chondrocyte maturation, but implicate Axin2 as an important modulator of the terminal stages of endochondral bone formation.

  6. implants lacking primary stability undergo osseointegration, provided Wnt (show WNT2 Proteins) signalling is amplified. Fibrous encapsulation can be prevented and osseointegration assured if Wnt (show WNT2 Proteins) signalling is elevated at the time of implant placement.

  7. Axin2(-/-) PF-sutures lack physiological endochondral ossification

  8. Axin2(+) cells can give rise to spatially and functionally restricted populations of adult neural stem cells in the subventricular zone.

  9. Axin2-positive tympanic border cells are Wnt (show WNT2 Proteins) responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea.

  10. Runx2 (show RUNX2 Proteins) protein represses Axin2 expression in osteoblasts and is required for craniosynostosis in Axin2-deficient mice

AXIN2 Protein Profile

Protein Summary

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Gene names and symbols associated with Axin 2 Proteins (AXIN2)

  • axin 2 (AXIN2)
  • axin 2 (conductin, axil) (axin2)
  • Axin-related protein (xarp)
  • axin 2 (Axin2)
  • axin2 (Axin2)
  • arp-A protein
  • Axi1 protein
  • Axil protein
  • axin-2 protein
  • axin2 protein
  • Conductin protein
  • MGC81576 protein
  • ODCRCS protein
  • wu:fb37c08 protein
  • xarp protein
  • zgc:111942 protein

Protein level used designations for Axin 2 Proteins (AXIN2)

axin 2 (conductin, axil) , axin-2 , axin-related protein , axin 2 , Axin-related protein , axin-2-like , axin-like protein , axis inhibition protein 2 , conductin , etID37069.3

GENE ID SPECIES
395152 Gallus gallus
447702 Xenopus laevis
468301 Pan troglodytes
511619 Bos taurus
100024610 Monodelphis domestica
100135020 Xenopus (Silurana) tropicalis
100380149 Xenopus (Silurana) tropicalis
100431721 Pongo abelii
29134 Rattus norvegicus
8313 Homo sapiens
490903 Canis lupus familiaris
58080 Danio rerio
12006 Mus musculus
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